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Bone Morphogenetic Proteins im Skelettsystem—

eine zusammenfassende Darstellung

Bone morphogenetic proteins in the skeletal system

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Zusammenfassung

Bone Morphogenetic Proteins (BMPs) gehören zur Superfamilie des Transforming Growth Factor-β (TGF-β). Die Bedeutung dieser Proteine für Regenerationsvorgänge in Geweben und Organen wurde in den letzten Jahren zunehmend deutlicher. Vor allem Studien zur fötalen Entwicklung zeigen die wichtige Rolle dieser Proteine für die Entstehung und Differenzierung von Organen, wobei fehlende oder mutierte BMPs zu Missbildungen oder sogar zum Abort führen können. Auch im erwachsenen Organismus wird zunehmend die regenerative Bedeutung dieser Proteine erkannt. So können die BMPs zur Heilung von Frakturen und zur Behandlung von Gelenkerkrankungen beitragen. Zur Behandlung von therapierefraktären Frakturen wurde BMP-7 bereits für den lokalen klinischen Einsatz zugelassen. Bei degenerativen Gelenkerkrankungen weisen experimentelle Daten auf eine verminderte BMP-Expression im Knorpelgewebe hin. Deshalb könnten BMPs einen neuen vielversprechenden Ansatz bei der Therapie dieser Erkrankungen darstellen. In dieser Übersicht soll daher die Gruppe der Bone Morphogenetic Proteins vorgestellt und bisherige und mögliche zukünftige klinische Anwendungsgebiete diskutiert werden.

Summary

Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-β superfamily. Their potential for organ and tissue regeneration and repair has been intensively investigated in recent years. Studies on fetal development have demonstrated the important role of these proteins for the development and differentiation of different organs. Misexpression or mutation of BMPs may lead to severe abnormalities or even abortion. However, a regenerative potential has also been recognized for the adult organism. BMPs support fracture healing and may contribute to treatment of joint diseases. Thus, BMP-7 is one of the first BMPs approved for clinical application in non-unions of bone fractures resistent to conventional therapy. In degenerative and inflammatory joint diseases, experimental data suggest a decrease of BMP expression in cartilage tissue. Therefore, BMPs could be promising therapeutic candidates in these diseases, although more detailed analyses are necessary. In this review we will focus on bone morphogenetic proteins and discuss present and putative future clinical applications.

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Authors and Affiliations

  1. Zentrum Innere Medizin, Abteilung Nephrologie und Rheumatologie, Universitätsklinikum der Georg-August-Universität Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany

    C. P. Bramlage,  G.-A. Müller &  F. Strutz

  2. Medizinische Klinik mit Schwerpunkt Rheumatologie und klinische Immunologie, Charité Universitätsklinik, Humboldt Universität, Berlin

    T. Häupl &  C. Kaps

  3. Institut für Klinische Pharmakologie, Medizinische Fakultät, Technische Universität, Dresden

    P. Bramlage

Authors
  1. C. P. Bramlage
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  2. T. Häupl
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  3. C. Kaps
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  4. P. Bramlage
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  5. G.-A. Müller
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  6. F. Strutz
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Correspondence to C. P. Bramlage.

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Bramlage, C.P., Häupl, T., Kaps, C. et al. Bone Morphogenetic Proteins im Skelettsystem—. Z. Rheumatol. 64, 416–422 (2005). https://doi.org/10.1007/s00393-005-0665-0

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  • DOI: https://doi.org/10.1007/s00393-005-0665-0

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