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Prognostic impact of atrial fibrillation in cardiogenic shock complicating acute myocardial infarction: a substudy of the IABP-SHOCK II trial

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Abstract

Background

Aim of the current study was to analyse the impact of atrial fibrillation (AF) on prognosis in patients with cardiogenic shock (CS) complicating acute myocardial infarction (AMI), which has never been investigated yet.

Methods

The current analysis is a substudy of the IABP-SHOCK II trial. Patients were grouped according to the presence or absence of AF. The primary endpoint was all-cause mortality at 30-day follow-up. Secondary endpoints included all-cause mortality, recurrent myocardial infarction, repeat revascularisation, and stroke at 12 months.

Results

AF was documented in 28.2% (n = 169) of all 600 patients initially enrolled in the IABP-SHOCK II trial. There were no significant differences with respect to mortality at 30 days and 12 months between patients with and without AF (p = 0.81, p = 0.74). Similarly, the rates of recurrent myocardial infarction, repeat revascularisation, and stroke did not differ between groups (all p > 0.05). There was no interaction of intraaortic balloon counterpulsation (IABP) and no IABP in patients with or without AF with respect to clinical outcome at 30 days and 12 months (p > 0.05).

Conclusion

AF is not associated with clinical outcome at 30 days and 12 months in CS complicating AMI.

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Author information

Author notes

  1. Suzanne de Waha, Katharina Schoene, Uwe Zeymer and Holger Thiele are equally contributing authors.

Authors and Affiliations

  1. University Heart Centre Luebeck, Department of Cardiology, Angiology, and Intensive Care Medicine, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, 23538, Luebeck, Germany

    Suzanne de Waha, Georg Fuernau, Steffen Desch, Ingo Eitel, Janine Pöss, Roza Meyer-Saraei, Charlotte Eitel & Roland Tilz

  2. German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Luebeck, Luebeck, Germany

    Suzanne de Waha, Georg Fuernau, Steffen Desch, Ingo Eitel, Janine Pöss, Roza Meyer-Saraei, Charlotte Eitel & Roland Tilz

  3. Heart Centre Leipzig, Department of Internal Medicine–Cardiology, University of Leipzig, Leipzig, Germany

    Katharina Schoene, Steffen Desch, Gerhard Schuler & Holger Thiele

  4. Martin Luther University Halle-Wittenberg, Department of Cardiology and Angiology, Halle/Saale, Germany

    Karl Werdan

  5. Institut für Herzinfarktforschung, Ludwigshafen, Germany

    Steffen Schneider, Taoufik Ouarrak & Uwe Zeymer

  6. Klinikum Ludwigshafen, Medical Clinic B, Ludwigshafen, Germany

    Uwe Zeymer

Authors
  1. Suzanne de Waha
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  2. Katharina Schoene
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  3. Georg Fuernau
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  4. Steffen Desch
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  5. Ingo Eitel
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  6. Janine Pöss
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  7. Roza Meyer-Saraei
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  8. Charlotte Eitel
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  9. Roland Tilz
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  10. Gerhard Schuler
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  11. Karl Werdan
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  12. Steffen Schneider
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  13. Taoufik Ouarrak
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  14. Uwe Zeymer
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  15. Holger Thiele
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Corresponding author

Correspondence to Suzanne de Waha.

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Funding

The IABP-SHOCK II trial was supported by grants from the German Research Foundation, the German Heart Research Foundation, the German Cardiac Society, Arbeitsgemeinschaft Leitende Kardiologische Krankenhausärzte, the University of Leipzig–Heart Centre, and by unrestricted grants from Maquet Cardiopulmonary as well as Teleflex Medical.

Conflict of interest

None relevant to the current study.

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de Waha, S., Schoene, K., Fuernau, G. et al. Prognostic impact of atrial fibrillation in cardiogenic shock complicating acute myocardial infarction: a substudy of the IABP-SHOCK II trial. Clin Res Cardiol 107, 233–240 (2018). https://doi.org/10.1007/s00392-017-1175-1

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  • DOI: https://doi.org/10.1007/s00392-017-1175-1

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