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Polymorphisms of miRNAs genes are associated with the risk and prognosis of coronary artery disease

  • Original Paper
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Clinical Research in Cardiology Aims and scope Submit manuscript

Abstract

Background

MicroRNAs (miRNAs) are small, single-stranded, non-protein-coding RNAs of about 22 nucleotides. miRNA molecules have been identified that plays key roles in a broad range of physiologic and pathologic processes. Polymorphisms in the corresponding sequence space are likely to make a significant contribution to phenotypic variation.

Methods and results

To assess the variations of rs11614913 T → C in hsa-mir-196a2 and rs3746444 A → G in hsa-mir-499 in the complex etiology of coronary artery disease (CAD), 956 CAD patients diagnosed by coronary arterial angiography and 620 controls were enrolled. Among the patients, 785 (785/956) had complete follow-ups for 42 months. The variant genotypes CC/CT of hsa-mir-196a2 rs11614913 T → C were not associated with a significantly increased risk of CAD (adjusted OR = 1.02, 95% CI = 0.76–1.38), compared with wide genotype TT, but CC and CC/CT genotypes were associated with 34 and 35% increased risks of serious prognosis of CAD (adjusted HR = 1.34, 95% CI = 1.02–1.75 for CC; adjusted HR = 1.35, 95% CI = 1.03–1.75 for CC/CT). In the variant of hsa-mir-499 rs3746444A → G, GG was associated with the 223% increased risk of CAD (adjusted OR = 3.23, 95% CI = 1.56–6.67). Cox regression analysis showed that age, smoking status, numbers of pathological changes in coronary arteries, rs11614913 T → C, and diabetes mellitus were associated with serious prognosis of CAD.

Conclusion

Our findings strongly implicate the functional miRNAs polymorphisms of hsa-mir-196a2 and hsa-mir-499 genes may modulate the occurrence or prognosis in Chinese CAD.

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Abbreviations

CAD:

Coronary artery disease

DM:

Diabetes mellitus

TC:

Total cholesterol

TG:

Triglyceride

HDL-C:

High density lipoprotein cholesterol

LDL-C:

Low density lipoprotein cholesterol

LD:

Linkage-disequilibrium

SNP:

Single nucleotide polymorphism

OR:

Odds ratio

HR:

Hazard risk

CI:

Confidence interval

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Acknowledgments

This study was supported by the National Natural Science Foundation of China (30901230) and the fund of Scientific Research Priming Project of the New Doctors in Southeast University (9225002435).

Conflict of interest

None declared.

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Authors and Affiliations

  1. Department of Cardiology, ZhongDa Hospital, Southeast University, Nanjing, China

    Hong Zhi, Genshan Ma, Xingzhou Ye & Jiaju Zhang

  2. Department of Epidemiology and Biostatistics, Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, 87 Ding Jiaqiao Rd, Nanjing, 210009, China

    Lina Wang, Xiaojin Yu, Yi Zhu, Yu Zhang & Bei Wang

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  1. Hong Zhi
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  2. Lina Wang
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Correspondence to Lina Wang.

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Zhi, H., Wang, L., Ma, G. et al. Polymorphisms of miRNAs genes are associated with the risk and prognosis of coronary artery disease. Clin Res Cardiol 101, 289–296 (2012). https://doi.org/10.1007/s00392-011-0391-3

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  • DOI: https://doi.org/10.1007/s00392-011-0391-3

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