Abstract
Heart rate is an independent risk factor for patients with cardiovascular disease, in particular with arterial hypertension, myocardial infarction, coronary artery disease and heart failure. This relation is supported by a large number of animal studies as well as clinical trials which are summarized in this article. These studies demonstrated detrimental effects of increased heart rate on the function and structure of the cardiovascular system. Heart rate can be easily detected during physical examination of the patient and therefore allows a simple conclusion on prognosis and efficiency of therapy.
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References
Levine JH (1997) Rest rate and life expectancy. J Am Coll Cardiol 30:1104–1106
Opie LH, Perlroth MG (2004) Ventricular function (Chapter 12). In: Opie LH (ed) Heart physiology: from cell to circulation. 4th edn Lippincott Williams and Wilkens, pp 351–401
Katz A (2005) Physiology of the heart. 4th edn. Lippincott Williams and Wilkens
Ferrari R, Rapezzi C, Clombardi F (1999) Increased heart rate is detrimental: the myocardial metabolic theory. Eur Heart J 1 (suppl H):H24–H28
Communal C, Singh K, Sawyer DB, Colucci WS (1999) Opposing effects of beta1-and beta2-adrenergic receptors on cardiac myocyte apoptosis. Role of pertussis toxin-senstive Gprotein. Circulation 100:2210–2220
Schwarz PJ (1999) The neural control of heart rate and risk stratification after myocardial infarction. Eur Heart J 1(suppl H):H33–43
Coburn FA, Ross MG, Rivera MS (1971) Observations on the relation of heart rate, life span, weight and mineralization in the digoxin-treated A/J Mouse. Hopkins Med 128:169–193
Singh BN (2001) Morbidity and mortality in cardiovascular disorders: impact of reduced heart rate. J Cardiovasc Pharmacol Therapeut 6(4):313– 331
Kannel W, Wilson P, Blaire S (1985) Epidemiologic assessment of the role of physical activity and fitness in development of cardiovascular disease. Am Heart J 109:876–885
Gillum R, Makuc D, Feldman J (1991) Puls rate, coronary heart disease, and death: the NHANES I epidemiologic follow-up study. Am Heart J 121:172–177
Wilhelmsen l, Berglund G, Elmfeldt D, Tibblin G, Wedel H, Pennert K, Vedin A, Wilhelmsson C, Werko L (1986) The multifactor primary prevention trial in Goteborg, Sweden. Eur Heart J 7:279–288
Dyer A, Perski V, Stamler J, Paul O, Shekelle RB, Berkson DM, Lepper M, Schoenberger JA, Lindberg HA (1980) Heart rate as a prognostic factor for coronary heart disease and mortality: Findings in three Chicago epidemiologic studies. Am J Epidemiol 112 (6):736–749
Goldberg R, Larson M, Levy D (1996) Factors associated with survival to 75 years of age in middle-aged men and women: the Framingham study. Arch Intern Med 156:505–509
Palatini P, Casiglia E, Julius S, Pessina AC (1999) Heart rate: A risk factor for cardiovascular mortality in elderly men. Arch Intern Med 159:585– 592
Shaper AG, Wannamethee G, Macfarlane PW, Walker M (1993) Heart rate, ischemic heart disease and sudden cardiac death in middle-aged British men. Br Heart J 70:49–55
Cole RC, Foody MJ, Blackstone HE, Lauer SM (2000) Heart rate recovery after submaximal exercise testing as a predictor of mortality in a cardiovascularly healthy cohort. Ann Intern Med 132:552–555
Jouven X, Empana J-P, Schwartz PJ, Desnos M, Courbon D, Ducimetire P (2005) Heart-rate profile during exercise as a predictor of sudden death. N Engl J Med 352:1951–1958
Mensink GB, Hofmeister H (1997) The relationship between resting heart rate and all-cause cardiovascular and cancer mortality. Eur. Heart J 18:1404–1410
Benetos A, Rucnichi A, Thomas F, Safar M, Guize Ll (1999) Influence of heart rate on mortality in a French population: Role of age, gender and blood pressure. Hypertension 33:44–52
Levy RL, White PD, Stroud WD (1945) Transient Tachykardia: Prognostic significance alone and in association with transient hypertension. JAMA 129:585–588
Palatini P, Casiglia E, Pauletto P (1994) Relation between physical training and ambulatory blood pressure in stage I hypertensive subjects. Results of the Harvest Trial. Circulation 90:2870–2872
Gillum R (1988) The epidemiology of resting heart rate in a national sample of men and women: Association with hypertension, coronary heart disease, blood pressure, and other cardiovascular risk factors. Am Heart J 116:163–174
Gillman M, Kannel W, Belanger A (1993) Influence of heart rate on mortality among persons with hypertension. The Framingham study . Am Heart J 125:1148–1154
Habib GB (1999) Reappraisal of heart rate as a risk factor in the general population. Europ Heart J (suppl H): H2
Stanley AG, Patel H, Knight AL (2000) Mechanical strain-induced human vascular matrix synthesis: the role of angiotensin II. J Renin Angiotensin Aldosterone Syst 1:32–35
Benetos A, Adamopoulos C, Bureau J-M (2002) Determinants of accelerated progression of arterial stiffness in normotensive subjects and in treated hypertensive subjects over a 6-year period. Circulation 105:1202–1207
Mangioni AA, Mircoli L, Giannattasio C (1996) Heart rate-dependence of arterial distensibility in vivo. J Hypertens 14:897–901
Bassiouny HS, Zarins CK, Kadowaki MH, Glagov S (1994) Hemodynamic stress and experimental aortoiliac atherosclerosis. J Vasc Surg 19:426–434
Beere PA, Glagov S, Zarins CK (1984) Retarding effect of lowered heart rate on coronary atherosclerosis. Science 226:180–182
Perski A, Hamsten A, Lindvall K, Theorell T (1988) Heart rate correlates with severity of coronary atherosclerosis in young postinfarction patients. Am Heart J 116:1369–1373
Perski A, Olsson G, Landou C, de Faire U, Theorell T, Hamsten A (1992) Minimum heart rate and coronary atherosclerosis: Independent relations to global severity and rate of progression of angiographic lesions in men with myocardial infarction at a young age. Am Heart J 123:609–616
Diaz A, Bourassa GM, Guertin MC , Tardif JC (2005) Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease. Eur Heart J 26:967–974
Kaplan RJ, Manuck BS, Adams MR, Weingand KW, Clarkson TB (1987) Inhibition of coronary atherosclerosis by propranolol in behaviorally predisposed monkeys fed an atherogenic diet. Circulation 76:1364–1372
Richardson PD, Davies MJ, Born GVR (1989) Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques. Lancet 2:941–944
Lee RT, Gordzinsky AJ, Frank EH, Kamm RD, Schoen JF (1991) Structure- dependent dynamic mechanical behavior of fibrous caps from human atherosclerotic plaques. Circulation 83:1764–1770
Heidland EU, Strauer EB (2001) Left ventricular muscle mass and elevated heart rate are associated with coronary plaque disruption. Circulation 104:1477–1482
Hjalmarson A, Gilpin E, Kjekshus J, Schieman G, Nicod P, Henning H, Ross J Jr (1990) Influence of heart rate on mortality after acute myocardial infarction. Am J Cardiol 65:547–553
Zuanetti G, Hernndes-Bernal F, Rossi A, Comerio G, Paolucci G, Maggioni AP (1999) Relevance of heart rate as a prognostic factor in myocardial infarction: the GISSI experience. Eur Heart J 1 (suppl H):H52–H57
Gundersen T, Groettum P, Pedersen T, Kjekshus J, for the Norwegian Timolol Multi-center Study Group (1986) Effect of timolol on mortality and reinfarction after acute myocardial infarction: Prognostic importance of heart rate at rest. Am J Cardiol 58:20–24
Kendall MJ, Lynch KP, Hjalmarson A, Kjekshus J (1995) Beta-blockers and sudden cardiac death. Annals of Internal Medicine 123(5):358–367
Hjalmarson A (1997) Effects of beta blockade on sudden cardiac death during acute myocardial infarction and the postinfarction period. Am J Cardiol 80(9B):35J–39J
Beta-blocker Heart Attack Trial Research Group (1982) A randomized trial of propranolol in patients with acute myocardial infarction. Mortality results. JAMA 247(12):1707–1714
Danish Study Group on Verapamil in myocardial infarction (1990) Effect of verapamil on mortality and major events after acute myocardial infarction (the Danish Verapamil Infarction Trial II (DAVIT II). Am J Cardiol 66:770–785
Olsson B, Blomström P, Sabel KG, Olsson WH (1984) Incessant ectopic atrial tachycardia: successful surgical treatment with regression of dilated cardiomyopathy picture. Am J Cardiol 53:1465–1466
Peters KG, Kienzle MG (1988) Severe cardiomyopathy due to chronic rapidly conducted atrial fibrillation: complete recovery after restoration of sinus rhythm. Am J Med 85:242–244
Bowditch HP (1871) Über die Eigentümlichkeit der Reizbarkeit, welche die Muskelfasern des Herzens zeigen. Ber Sächs Ges (Akad) Wiss 652–689
Hasenfuss G, Reinecke H, Studer R, Meyer M, Pieske B, Holtz J, Holubarsch C, Posival H, Just H, Drexler H (1994) Relation between myocardial function and expression of sarcoplasmatic reticulum Ca2+-ATPase in failing and nonfailing human myocardium. Circ Res 75:434–442
Böhm M, La Rosee K, Schmidt U, Schulz C, Schwinger RHG, Erdmann E (1992) Force-frequency relationship and inotropic stimulation in the nonfailing and failing human myocardium: implications for the medical treatment of heart failure. Clin Invest 70:421–425
Kjekshus J, Gullestad L (1999a) Heart rate as a therapeutic target in heart failure. Eur Heart J (suppl H):H64– H69
Dobson PD (2003) On being the right size: Heart design, mitochondrial efficiency and lifespan potential. Clin Experiment Pharm Physiol 30:590– 597
Azbel MY (1994) Universal biological scaling and mortality. Proc Natl Acad Sci USA 91(26):12453–12457
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Reil, JC., Böhm, M. The role of heart rate in the development of cardiovascular disease. Clin Res Cardiol 96, 585–592 (2007). https://doi.org/10.1007/s00392-007-0537-5
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DOI: https://doi.org/10.1007/s00392-007-0537-5