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Incidence and prognosis of pulmonary metastasis in colorectal cancer: a population-based study

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

It is unclear how primary tumor location affects the pulmonary metastasis in colorectal cancer patients with different primary tumor locations. We aim to explore the relationship between primary tumor location and the incidence and prognosis of colorectal cancer patients with pulmonary metastasis at diagnosis.

Methods

From Surveillance, Epidemiology, and End Results (SEER) database, 9920 out of 192,969 CRC patients were identified with pulmonary metastasis at diagnosis between 2010 and 2015. Patients were classified into three subsets according to primary tumor location. The incidence of pulmonary metastasis and median survival were calculated. Multivariable logistic and Cox regression were performed to identify the risk factors of pulmonary metastasis and prognosis.

Results

The incidence of pulmonary metastasis was 5.14% in the entire colorectal cancer cohort and 25.66% in metastatic colorectal cancer patients. The median survival of those patients was 10 months. Rectal cancer patients exhibited the highest incidence of pulmonary metastasis, while they had the longest median survival (15 months). The right-sided colon cancer patients had the lowest incidence of pulmonary metastasis, but the shortest median survival (8 months). 61 to 80 years old, over 80, black, two or three extrapulmonary metastatic sites and CEA-positive had a negative influence both on the incidence and prognosis.

Conclusions

The importance of primary tumor location in affecting the incidence of pulmonary metastasis and prognosis of colorectal cancer patients was highlighted in this study. Primary tumor location should be considered in clinical interference and personalized treatment for colorectal cancer patients with pulmonary metastasis.

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Acknowledgments

The authors thank the Surveillance, Epidemiology, and End Results (SEER) Program.

Funding

This study is supported by the Major State Basic Research Development Program of China (973 Program, 2015CB554007), the Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College, HUST, and the Academic Medical Doctor Supporting Program of Tongji Medical College, HUST.

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Author notes

  1. Yizhi Ge and author Shijun Lei contributed equally to this work

Authors and Affiliations

  1. Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Yizhi Ge, Shijun Lei, Bo Cai, Lin Wang & Zheng Wang

  2. Jame J. Peters VA Medical Center, Bronx, NY, 10468, USA

    Xiang Gao

  3. Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Guobin Wang & Zheng Wang

  4. Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Lin Wang

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  1. Yizhi Ge
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Contributions

Yizhi Ge and Shijun Lei: Research design, conducting, data collection, interpretation and analysis, manuscript, and artworks drafting. They contribute equally to this work. Bo Cai, and Xiang Gao: Work design and manuscript’s critical revision. Guobin Wang, Lin Wang, and Zheng Wang: Research design, data analysis, results interpretation, paper writing, and critical revision of the manuscript. All authors approved the final version and agreed to be accountable for all aspects of the work.

Corresponding authors

Correspondence to Guobin Wang, Lin Wang or Zheng Wang.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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The data we used can be downloaded from https://seer.cancer.gov/.

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Ge, Y., Lei, S., Cai, B. et al. Incidence and prognosis of pulmonary metastasis in colorectal cancer: a population-based study. Int J Colorectal Dis 35, 223–232 (2020). https://doi.org/10.1007/s00384-019-03434-8

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