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Clinicopathological characteristics and frequency of multiple rectal neuroendocrine tumors: a single-center retrospective study

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Abstract

Background

Rectal multiple neuroendocrine tumors (M-NETs) are rare, with only few epidemiologic reports on the topic. Therefore, their clinicopathological features are not completely known, and the appropriate treatment strategy has not been established.

Purpose

This study aimed to compare the clinicopathological malignant potential (lymphatic or venous invasion-positive and lymph node metastasis rates) of M-NETs with that of solitary NETs (S-NETs).

Methods

We retrospectively investigated 369 patients with NETs of the rectum. Patients who underwent colonoscopy at the Cancer Institute Hospital between January 1979 and 2016 and diagnosed with S-NETs were included, and S-NETs were found in 348 patients. Patients with M-NETs were classified into two groups as follows: patients with < 8 tumors (several (S) group, n = 21) and those with ≥ 8 tumors (numerous (N) group, n = 3).

Results

The overall frequency of M-NETs was 5.7% and that of the N group was 0.8%. The mean tumor diameter in the N group was 6.0 mm (range, 4–8 mm). The lymphatic invasion rates of the S-NETs, and S and N groups of the M-NETs were 8.9%, 5.6%, and 66.7%, respectively. Moreover, the lymph node metastasis rates were 9.2%, 11.1%, and 33.3, respectively.

Conclusions

While M-NETs in the S and N groups had different characteristics, they were rarer in the N group. The N group may have higher rates of lymphatic invasion and lymph node metastasis regardless of tumor size.

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Acknowledgments

We would like to thank the pathologists, Hiroshi Kawachi and Noriko Yamamoto, who contributed to the pathological diagnoses in this study.

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Authors and Affiliations

  1. Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan

    Yusuke Nishikawa, Akiko Chino, Daisuke Ide, Shoichi Saito, Masahiro Igarashi & Junko Fujisaki

  2. Departments of Gastroenterology, Toho University Oomori hospital, Tokyo, Japan

    Yusuke Nishikawa & Yoshinori Igarashi

  3. Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan

    Manabu Takamatsu

Authors
  1. Yusuke Nishikawa
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  2. Akiko Chino
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  3. Daisuke Ide
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Correspondence to Akiko Chino.

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Nishikawa, Y., Chino, A., Ide, D. et al. Clinicopathological characteristics and frequency of multiple rectal neuroendocrine tumors: a single-center retrospective study. Int J Colorectal Dis 34, 1887–1894 (2019). https://doi.org/10.1007/s00384-019-03405-z

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