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Rotating night shift work, sleep, and colorectal adenoma in women

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Abstract

Purpose

This study aims to investigate the associations of rotating night shift work history and sleep duration with risk of colorectal adenoma.

Methods

We evaluated 56,275 cancer-free participants of the Nurses’ Health Study II, who had their first colonoscopy or sigmoidoscopy between 1991 and 2011; rotating night shift work and sleep duration were reported by mailed questionnaire. Multivariable-adjusted logistic regression was used to estimate relative risks (RR) of colorectal adenoma, with 95% confidence intervals (CI), across categories of rotating night shift work history (none, 1–4, 5–9, and ≥10 years) and sleep duration (≤5, 6, 7, 8, and ≥9 h/day).

Results

We found no association between duration of rotating night shift work and occurrence of colorectal adenoma (p-trend across shift work categories = 0.5). Women with the longest durations of rotating night shift work (≥10 years) had a similar risk of adenoma compared to women without a history of rotating night shift work (multivariable-adjusted RR = 0.96, 95% CI = 0.83–1.11). Similarly, there were no associations of shorter or longer sleep durations with adenoma risk (p-trend = 0.2 across sleep durations of ≤5 through 7 h/day and p-trend = 0.5 across sleep durations of 7 through ≥9 h/day). Results were similar when we examined associations according to adenoma location and subtype.

Conclusions

Our results do not support an association between rotating night shift work or sleep duration and risk of colorectal adenoma in women.

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Acknowledgments

We would like to thank the participants and staff of the Nurses’ Health Study II for their valuable contributions as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, and WY.

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Authors and Affiliations

  1. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, 181 Longwood Avenue, Room 448, Boston, MA, 02115, USA

    Elizabeth E. Devore, Eva S. Schernhammer, Xuehong Zhang, Walter C. Willett, Charles S. Fuchs, Andrew T. Chan, Edward Giovannucci & Esther K. Wei

  2. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA

    Jennifer Massa, Kana Wu, Walter C. Willett & Edward Giovannucci

  3. Department of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria

    Kyriaki Papantoniou & Eva S. Schernhammer

  4. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA

    Eva S. Schernhammer, Walter C. Willett, Shuji Ogino & Edward Giovannucci

  5. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA

    Charles S. Fuchs & Shuji Ogino

  6. Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA

    Andrew T. Chan

  7. Division of MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Shuji Ogino

  8. California Pacific Medical Center Research Institute, San Francisco, CA, USA

    Esther K. Wei

Authors
  1. Elizabeth E. Devore
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  2. Jennifer Massa
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  3. Kyriaki Papantoniou
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  4. Eva S. Schernhammer
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  5. Kana Wu
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  6. Xuehong Zhang
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  7. Walter C. Willett
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  8. Charles S. Fuchs
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  9. Andrew T. Chan
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  10. Shuji Ogino
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  11. Edward Giovannucci
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  12. Esther K. Wei
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Corresponding author

Correspondence to Elizabeth E. Devore.

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Funding

This research was generously supported by grants from the National Institutes of Health. The National Institute for Occupational Safety and Health and Centers for Disease Control and Prevention funded this project (R21 OH010204 and R01 OH009803), with additional support from the National Cancer Institute (P50 CA127003 and R35 CA197735). The National Cancer Institute also funds the Nurses’ Health Study II cohort (UM1 CA176726).

Disclosure of potential conflicts of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Additional information

Elizabeth E. Devore and Jennifer Massa contributed equally to this manuscript.

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Devore, E.E., Massa, J., Papantoniou, K. et al. Rotating night shift work, sleep, and colorectal adenoma in women. Int J Colorectal Dis 32, 1013–1018 (2017). https://doi.org/10.1007/s00384-017-2758-z

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  • DOI: https://doi.org/10.1007/s00384-017-2758-z

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