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Impact of perioperative hypoglycaemia in subjects with diabetes undergoing colorectal surgery

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Introduction

This study explores the association between perioperative hypoglycaemia and surgical outcomes in subjects with diabetes, undergoing colorectal surgery.

Methods

A retrospective review of 149 subjects with Type 2 Diabetes Mellitus (DM) who underwent colorectal surgery between 2010 and 2015 was performed. Perioperative glucose levels, glycated haemoglobin (HbA1c) measurements within 3 months of surgery and surgical complications based on Clavien-Dindo classification were analysed.

Results

The mean age was 67 years (67 ± 11.2). Perioperative hypoglycaemia was found in 7.4% of subjects. The mean HbA1c of subjects with Clavien 2 and above surgical complications were higher than patients with Clavien 1 or no complications, Hba1c 7.6% (7.6 ± 2.5%) and 7.0% (7.0 ± 1.1%, p = 0.008), respectively. Similar findings in subjects with Clavien 3 and above complications, HbA1c of 8.2% (8.2 ± 3.9%) as compared to those with Clavien 2 and below complications, 7.2% (7.2 ± 1.5%, p = 0.001). Adjusted multivariate analysis showed that hypoglycaemia was significantly associated with Clavien 2 and above surgical complications, OR of 19.0 (CI 2.23–162, p = 0.007). Preoperative hypoglycaemia was associated with Clavien 2 and above surgical complications, OR 10.7 (CI 1.22–94.1, p = 0.032). Suboptimal glycaemic control (Hba1c >8.0%) was significantly associated with Clavien 2 and above complications, OR 2.48 (CI 1.04–5.91, p = 0.04), but not with Clavien 3 and above complications, OR 1.50 (CI 0.450–4.98, p = 0.511).

Conclusion

Perioperative hypoglycaemia is associated with adverse surgical outcomes in diabetic patients undergoing colorectal surgery. Prevention of hypoglycaemia may improve surgical outcomes. HbA1c is an independent predictor for adverse surgical outcomes.

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Authors and Affiliations

  1. Department of General Surgery, Khoo Teck Puat Hospital, Singapore, Singapore

    Si Ning Serene Goh & Kok Yang Tan

  2. Diabetes Centre, Khoo Teck Puat Hospital, Singapore, Singapore

    Ester Yeoh

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  1. Si Ning Serene Goh
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  2. Ester Yeoh
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Correspondence to Si Ning Serene Goh.

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This article does not contain any studies with animals performed by any of the authors.

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Goh, S.N.S., Yeoh, E. & Tan, K.Y. Impact of perioperative hypoglycaemia in subjects with diabetes undergoing colorectal surgery. Int J Colorectal Dis 32, 209–214 (2017). https://doi.org/10.1007/s00384-016-2680-9

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  • DOI: https://doi.org/10.1007/s00384-016-2680-9

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