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Mesenteric fibromatosis

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Mesenteric fibromatosis is a rare, locally invasive, non-metastasizing type of intra-abdominal fibromatoses with a very high rate of recurrence. Because of rarity, these tumors pose a diagnostic and therapeutic challenge. These tumors may remain asymptomatic, but commonly present as a painless mass. There are no clear treatment guidelines. Surgical excision with wide margin is the preferred modality of treatment. Medical therapy is indicated for inoperable and recurrent tumors. There are several isolated case reports on mesenteric fibromatosis with different and unusual presentations and its complications. Though several studies have been published on extra-abdominal fibromatosis as well as on extramesenteric abdominal fibromatosis, but extensive research studies are still lacking on mesenteric fibromatosis. The aim of this article is to present current knowledge on mesenteric fibromatosis, our experience of four cases, and comprehensive review of available literature.

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References

  1. Middleton SB, Frayling IM, Phillips RK (2000) Desmoids in familial adenomatous polyposis are monoclonal proliferations. Br J Cancer 82:827

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. Weiss S, Goldblum JR (2001) Enzinger and Weiss’s soft tissue tumors, 4th edn. Mosby, St. Louis, pp 309–346

    Google Scholar 

  3. Koh PK, Loi C, Cao X et al (2007) Mesenteric desmoid tumors in Singapore familial adenomatous polyposis patients: clinical course and genetic profile in a predominantly Chinese population. Dis Colon Rectum 50:75–82

    Article  PubMed  Google Scholar 

  4. Burke AP, Sobin LH, Shekitka KM et al (1990) Intra-abdominal fibromatosis: a pathologic analysis of 130 tumors with comparison of clinical subgroups. Am J Surg Pathol 14:335

    Article  CAS  PubMed  Google Scholar 

  5. Wilcken N, Tattersall MH (1991) Endocrine therapy for desmoid tumors. Cancer 68:1384

    Article  CAS  PubMed  Google Scholar 

  6. Yantis RK, Spiro IJ, Compton CC et al (2000) Gastrointestinal stromal tumor versus intra-abdominal fibromatosis of the bowel wall: a clinically important differential diagnosis. Am J Surg Pathol 24:947

    Article  Google Scholar 

  7. Rodriguez JA, Guarda LA, Rosai J (2004) Mesenteric fibromatosis with involvement of the gastrointestinal tract. A GIST simulator: a study of 25 cases. Am J Clin Pathol 121:93

    Article  PubMed  Google Scholar 

  8. Huss S, Nehles J, Binot E et al (2013) β-catenin (CTNNB1) muatations and clinicopathological features of mesenteric desmoid-type fibromatosis. Histopathology 62:294–304

    Article  PubMed  Google Scholar 

  9. Baron RL, Jk L (1981) Mesenteric desmoid tumors: sonographic and computed-tomographic appearance. Radiology 140:777–9

    Article  CAS  PubMed  Google Scholar 

  10. Maconi G, Cristaldi M, Vago L et al (1998) Clinical, ultrasonographic and tomographic features on the natural evolution of primary mesenteric fibromatosis: a case report. Hepatogastroenterology 45:1663–66

    CAS  PubMed  Google Scholar 

  11. Zhu H, Chen H, Zhang S et al (2013) Intra-abdominal fibromatosis: differentiation from gastrointestinal stromal tumors based on biphasic contrast-enhanced CT findings. Clin Radiol 68:1133–9

    Article  CAS  PubMed  Google Scholar 

  12. Yeh BM, Joe BN, Sirlin CB et al (2008) Vascular contact with soft tissue: a sign of mesenteric masses at computed tomography. J Comput Assist Tomogr 32:1185–90

    Google Scholar 

  13. Tolan S, Shanks JH, Loh MY et al (2007) Fibromatosis: benign by name but not necessarily by nature. Clin Oncol 19:319–26

    Article  CAS  Google Scholar 

  14. Gega M, Yanagi H, Yoshikawa R et al (2006) Successful chemotherapeutic modality of doxorubicin plus dacarbazine for the treatment of desmoid tumors in association with familial adenomatous polyposis. J Clin Oncol 24:102

    Article  CAS  PubMed  Google Scholar 

  15. Lazar AJ, Tuvin D, Hajibashi S et al (2008) Specific mutations in the beta catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors. Am J Pathol 173:1518

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  16. Sakorafas GH, Nissotakis C, Peros G (2007) Abdominal desmoid tumors. Surg Oncol 16:131–42

    Article  PubMed  Google Scholar 

  17. Berri RN, Baumann DP, Madewell JE et al (2011) Desmoid tumor: current multidisciplinary approaches. Ann Plast Surg 67:551–64

    Article  CAS  PubMed  Google Scholar 

  18. Kasper B, Strobel P, Hohenberger P (2011) Desmoid tumors: clinical features and treatment options for advanced disease. Oncologist 16:682–93

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  19. Biermann JS (2000) Desmoid tumors. Curr Treat Options in Oncol 1:262–66

    Article  CAS  Google Scholar 

  20. Lahat G, Nachmany I, Itzkowitz E et al (2009) Surgery for sporadic abdominal desmoid tumor: is low/no recurrence an achievable goal? Israel Medical Association J 11:398–402

    Google Scholar 

  21. Kulaylat MN, Karakousis CP, Keaney CM et al (1999) Desmoid tumor: a pleomorphic lesion. Eur J of Surg Oncol 25:487–97

    Article  CAS  Google Scholar 

  22. Rosato L, Mondini G, Serbelloni M et al (2007) Intra-abdominal desmoid tumors: rare but important disease. G di Chir 28:20–24

    CAS  Google Scholar 

  23. Lotfi AM, Dozois RR, Gordon H et al (1989) Mesenteric fibromatosis complicating familial adenomatous polyposis: predisposing factors and results of treatment. Int J Colorectal Dis 4:30–36

    Article  CAS  PubMed  Google Scholar 

  24. Rodriguez-Bigas MA, Mahoney MC, Karakousis CP et al (1994) Desmoid tumors in patients with familial adenomatous polyposis. Cancer 74:1270–74

    Article  CAS  PubMed  Google Scholar 

  25. Khorsand J, Karakousis CP (1985) Desmoid tumors and their management. Am J Surg 149:215–18

    Article  CAS  PubMed  Google Scholar 

  26. Hansmann A, Adolph CP, Vogel T et al (2004) High-dose tamoxifen and sulindac as first line treatment for desmoid tumors. Cancer 100:612–20

    Article  CAS  PubMed  Google Scholar 

  27. Tonelli F, Ficari F, Valanzano R et al (2003) Treatment of desmoids and mesenteric fibromatosis in familial adenomatous polyposis with raloxifene. Tumori 89:391–96

    CAS  PubMed  Google Scholar 

  28. Bus PJ, Verspaget HW, Van Krieken JH et al (1999) Treatment of mesenteric desmoid tumors with the anti-estrogenic agent toremifene: case histories and an overview of the literature. Eur J Gastroenterol Hepatol 11:1179–83

    Article  CAS  PubMed  Google Scholar 

  29. Penel N, Le Cesne A, Bui BN et al (2011) Imatinib for progressive and recurrent aggressive fibromatosis (desmoid tumors): an FNCLCC/French Sarcoma Group phase II trial with a long term follow up. Ann Oncol 22:452–57

    Article  CAS  PubMed  Google Scholar 

  30. Auranen A, Kallajoki M, Lavonius M et al (2012) Mesenteric fibrosis—could it be desmoid? Duodecim 128:2562–8

    PubMed  Google Scholar 

  31. Ozuner CMG (1999) The clinical course of intra-abdominal desmoid tumors in patients with familial adenomatous polyposis. Colorectal Dis 1:168–73

    Article  PubMed  Google Scholar 

  32. Seow-Choen F (2008) The management of desmoids in patients with familial adenomatous polyposis. Acta Chir Lugosl 55:83–87

    Article  CAS  Google Scholar 

  33. Nieuwenhuis MH, Mathus-Vliegen EM, Baeten CG et al (2011) Evaluation of management of desmoid tumors associated with familial adenomatous polyposis in Dutch patients. Br J Cancer 104:37–42

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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  1. Lady Hardinge Medical College and associated Dr RML Hospital, New Delhi, India

    Poras Chaudhary

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  1. Poras Chaudhary
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Correspondence to Poras Chaudhary.

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Chaudhary, P. Mesenteric fibromatosis. Int J Colorectal Dis 29, 1445–1451 (2014). https://doi.org/10.1007/s00384-014-1995-7

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  • DOI: https://doi.org/10.1007/s00384-014-1995-7

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