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The impact of expressions of CD97 and its ligand CD55 at the invasion front on prognosis of rectal adenocarcinoma

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Background

Various evidence show that CD97 plays an important role in tumor differentiation, migration, invasiveness, and metastasis by binding its cellular ligand CD55. CD55 is a complement regulatory protein expressed by cells to protect them from bystander attack by complement, and it has been shown to be an indicator of poor prognostic in several cancers.

Methods

CD97 and CD55 stains were detected in tumor tissues from 71 cases of rectal adenocarcinomas and their corresponding normal colorectal tissues by immunohistochemistry.

Results

The expressions of CD97 and CD55 in rectal tumor tissues were significantly higher than those in normal colorectal tissues (P < 0.05, both). The patients with recurrence and/or metastasis had significantly higher expressions of CD97 at tumor cells and CD55 at stroma (67.8% [21/31] and 63.6% [21/33]) at the invasion front than those patients without recurrence and/or metastasis (25.0% [10/40] and 26.3% [10/38]). The expression of CD97 at tumor cell at the invasion front showed modest correlation with that of CD55 in the stroma at the invasion front(r = 0.392, P < 0.01). Univariate analysis revealed that lymph node metastasis (P = 0.001), stages II–IV (P = 0.026), and strong CD97 expression at tumor invasion front (P = 0.002) were shown to have a significant adverse impact on the postoperative survival rate. Moreover, lymph node metastasis (P = 0.037) and strong CD97 expression (P = 0.015) were associated with poor survival in a multivariate analysis.

Conclusions

Elevated expression of CD97 and its ligand CD55 at the invasion front correlate with tumor recurrence and metastasis, and CD95 may be a poor prognostic factor for rectal adenocarcinoma.

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Authors and Affiliations

  1. Department of General Surgery, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou, 325000, Zhejiang Province, China

    Shao-Liang Han, Chang Xu, Jun-Lin Li, Zhi Liu & Qi-Qiang Zeng

  2. Department of Histopathology, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou, 325000, China

    Xiu-Ling Wu

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  1. Shao-Liang Han
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  2. Chang Xu
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  3. Xiu-Ling Wu
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  4. Jun-Lin Li
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  6. Qi-Qiang Zeng
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Correspondence to Shao-Liang Han.

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Han, SL., Xu, C., Wu, XL. et al. The impact of expressions of CD97 and its ligand CD55 at the invasion front on prognosis of rectal adenocarcinoma. Int J Colorectal Dis 25, 695–702 (2010). https://doi.org/10.1007/s00384-010-0926-5

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  • DOI: https://doi.org/10.1007/s00384-010-0926-5

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