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Colloid vs. crystalloid infusions in gastrointestinal surgery and their different impact on the healing of intestinal anastomoses

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Abstract

Background

The aim of this study was to investigate if colloid infusions have different effects on intestinal anastomotic healing when compared to crystalloid infusions depending on the amount of the administered volume.

Materials and methods

Twenty-eight Wistar rats were randomly assigned to four groups receiving different amounts of either a crystalloid (Cry) or a colloid (Col) infusion solution. Animals with volume restriction (Cry (−) or Col (−)) were treated with a low and animals with volume overcharge (Cry (+) or Col (+)) with a high flow rate. All animals received an infusion for a 60-min period, while an end-to-end small bowel anastomosis was performed. At reoperation, the anastomotic bursting pressure (millimeters of mercury) was measured, as well as anastomotic hydroxyproline concentration. The presence of bowel wall edema was assessed histologically.

Results

Median bursting pressures were comparable in the Col (−) [118 mm Hg (range 113–170)], the Cry (−) [118 mm Hg (78–139)], and the Col (+) [97 mm Hg (65–152)] group. A significantly lower median bursting pressure was found in animals with crystalloid volume overload Cry (+) [73 mm Hg (60–101)]. Corresponding results were found for hydroxyproline concentration. Histology revealed submucosal edema in Cry (+) animals.

Conclusions

In case of a fixed, high-volume load, colloids seem to have benefits on intestinal anastomotic healing when compared to crystalloid infusions.

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Authors and Affiliations

  1. Department of Surgery, University of Freiburg, Freiburg, Germany

    Goran Marjanovic

  2. Institute of Pathology, University of Freiburg, Freiburg, Germany

    Sylvia Timme & Axel zur Hausen

  3. Department of General and Digestive Surgery, University of Freiburg, Hugstetter Strasse 55, DE-79106, Freiburg, Germany

    Goran Marjanovic, Christian Villain, Jens Hoeppner, Frank Makowiec, Philipp Holzner, Ulrich Theodor Hopt & Robert Obermaier

Authors
  1. Goran Marjanovic
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  2. Christian Villain
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  3. Sylvia Timme
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  4. Axel zur Hausen
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  7. Philipp Holzner
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Corresponding author

Correspondence to Goran Marjanovic.

Additional information

Goran Marjanovic and Christian Villain have equally contributed to the manuscript and share primary authorship.

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Marjanovic, G., Villain, C., Timme, S. et al. Colloid vs. crystalloid infusions in gastrointestinal surgery and their different impact on the healing of intestinal anastomoses. Int J Colorectal Dis 25, 491–498 (2010). https://doi.org/10.1007/s00384-009-0854-4

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  • DOI: https://doi.org/10.1007/s00384-009-0854-4

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