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Crohn’s disease in Tuzla region of Bosnia and Herzegovina: a 12-year study (1995–2006)

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Abstract

Background

Bosnia and Herzegovina (B&H) is one of the Eastern European countries with lacking data on Crohn’s disease (CD) epidemiology.

Goal

We aimed to assess incidence of CD in Tuzla Canton of B&H during a 12-year period (1995–2006).

Methods

We retrospectively evaluated hospital records of both CD inpatients and outpatients residing in Tuzla Canton of B&H (total of 496,280 inhabitants) between 1995 and 2006. Patient that satisfied previously described criteria were included in the study. Incidence rates were calculated with age standardisation using European standard population. Trends in incidence were evaluated as moving 3-year averages.

Results

During the observed period, 140 patients met the diagnostic criteria for CD. Mean annual incidence was found to be 2.3/105 (95% CI = 1.6–3.0) inhabitants ranging from 0.20 to 6.45 per 105. Mean annual crude incidence during the last 5 years of study (2002–2006) was 4.15/105 (95% CI = 3.35–4.95). The prevalence of CD, at the end of the observed period was found to be 28.2/105 (95% CI = 23.5–32.9). CD incidence increased dramatically from 0.27/105 in 1995–1997 to 4.84/105 in 2004–2006, as well as did the number of colonoscopies performed; from 29 in 1995 to 850 in 2006. We observed almost constant trend of around three new cases of CD per 100 colonoscopies performed.

Conclusions

(1)Our area is the region of moderate incidence of CD with the trend that remains toward continuing increase in the rates of CD, which is most likely a direct consequence of the growing number of performed colonoscopies. (2) We believe that in the future years, CD incidence in our region will probably further increase and stabilise at a level of around five cases per 105 inhabitants.

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References

  1. Podolsky DK (2002) Inflammatory bowel disease. N Engl J Med 347:417–429

    Article  PubMed  CAS  Google Scholar 

  2. Stone MA, Mayberry JF, Baker R (2003) Prevalence and management of inflammatory bowel disease: a cross-sectional study from central England. Eur J Gastroenterol Hepatol 15:1275–1280

    Article  PubMed  CAS  Google Scholar 

  3. Lapidus A (2001) The changing epidemiology of inflammatory bowel diseases. Acta Gastroenterol Belg 64:155–159

    PubMed  CAS  Google Scholar 

  4. Tsianos EV, Masalas CN, Merkouropoulos M et al (1994) Incidence of inflammatory bowel disease in north west Greece: rarity of Crohn's disease in an area where ulcerative colitis is common. Gut 35:369–372

    Article  PubMed  CAS  Google Scholar 

  5. Shivananda S, Lennard-Jones J, Logan R et al (1996) Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD). Gut 39:690–697

    Article  PubMed  CAS  Google Scholar 

  6. Lakatos L, Lakatos PL (2006) Is the incidence and prevalence of inflammatory bowel diseases increasing in Eastern Europe? Postgrad Med J 82:332–337

    Article  PubMed  CAS  Google Scholar 

  7. Vucelic B, Korac B, Sentic M et al (1991) Epidemiology of Crohn's disease in Zagreb, Yugoslavia: a ten-year prospective study. Int J Epidemiol 20:216–220

    Article  PubMed  CAS  Google Scholar 

  8. Gasche C, Scholmerich J, Brynskov J et al (2000) A simple classification of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998. Inflamm Bowel Dis 6:8–15

    PubMed  CAS  Google Scholar 

  9. Doll R, Cook P (1967) Summarizing indices for comparison of cancer incidence data. Int J Cancer 2:269–279

    Article  PubMed  CAS  Google Scholar 

  10. Shanahan F (2002) Crohn's disease. Lancet 359:62–69

    Article  PubMed  CAS  Google Scholar 

  11. Loftus EV Jr., Silverstein MD, Sandborn WJ et al (2000) Ulcerative colitis in Olmsted County, Minnesota, 1940–1993: incidence, prevalence, and survival. Gut 46:336–343

    Article  PubMed  Google Scholar 

  12. Gheorghe C, Pascu O, Gheorghe L et al (2004) Epidemiology of inflammatory bowel disease in adults who refer to gastroenterology care in Romania: a multicentre study. Eur J Gastroenterol Hepatol 16:1153–1159

    Article  PubMed  Google Scholar 

  13. Lakatos L, Mester G, Erdelyi Z et al (2004) Striking elevation in incidence and prevalence of inflammatory bowel disease in a province of western Hungary between 1977–2001. World J Gastroenterol 10:404–409

    PubMed  Google Scholar 

  14. Wiercinska-Drapalo A, Jaroszewicz J, Flisiak R et al (2005) Epidemiological characteristics of inflammatory bowel disease in North-Eastern Poland. World J Gastroenterol 11:2630–2633

    PubMed  Google Scholar 

  15. Jovanovic Z (1999) [Epidemiology of Crohn's disease in the Rijeka-Istra region]. Lijec Vjesn 121:8–13

    PubMed  CAS  Google Scholar 

  16. Sincic BM, Vucelic B, Persic M et al (2006) Incidence of inflammatory bowel disease in Primorsko-goranska County, Croatia, 2000–2004: a prospective population-based study. Scand J Gastroenterol 41:437–444

    Article  PubMed  Google Scholar 

  17. Molinie F, Gower-Rousseau C, Yzet T et al (2004) Opposite evolution in incidence of Crohn's disease and ulcerative colitis in Northern France (1988–1999). Gut 53:843–848

    Article  PubMed  CAS  Google Scholar 

  18. Fonager K, Sorensen HT, Olsen J (1997) Change in incidence of Crohn's disease and ulcerative colitis in Denmark. A study based on the National Registry of Patients, 1981–1992. Int J Epidemiol 26:1003–1008

    Article  PubMed  CAS  Google Scholar 

  19. Thomas GA, Millar-Jones D, Rhodes J et al (1995) Incidence of Crohn's disease in Cardiff over 60 years: 1986–1990 an update. Eur J Gastroenterol Hepatol 7:401–405

    PubMed  CAS  Google Scholar 

  20. Hildebrand H, Finkel Y, Grahnquist L et al (2003) Changing pattern of paediatric inflammatory bowel disease in northern Stockholm 1990–2001. Gut 52:1432–1434

    Article  PubMed  CAS  Google Scholar 

  21. Louis E, Collard A, Oger AF et al (2001) Behaviour of Crohn’s disease according to the Vienna classification: changing pattern over the course of the disease. Gut 49:777–782

    Article  PubMed  CAS  Google Scholar 

  22. Fedorak RN (2004) Is it time to re-classify Crohn's disease? Best Pract Res Clin Gastroenterol 18(Suppl):99–106

    Article  PubMed  Google Scholar 

  23. Cerveny P, Bortlik M, Kubena A et al (2007) Nonadherence in inflammatory bowel disease: results of factor analysis. Inflamm Bowel Dis 13:1244–1249

    Article  PubMed  Google Scholar 

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Acknowledgement

Nada Pavlovic-Calic and Nermin Salkic gave equal contribution to this paper

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Authors and Affiliations

  1. Department of Gastroenterology, Internal Medicine Hospital, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina

    Nada Pavlovic-Calic, Nermin N. Salkic, Adnan Gegic, Midhat Smajic & Ervin Alibegovic

  2. Miroslava Krleze 15/26, 75000, Tuzla, Bosnia and Herzegovina

    Nermin N. Salkic

Authors
  1. Nada Pavlovic-Calic
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  2. Nermin N. Salkic
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  3. Adnan Gegic
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  4. Midhat Smajic
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  5. Ervin Alibegovic
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Correspondence to Nermin N. Salkic.

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Pavlovic-Calic, N., Salkic, N.N., Gegic, A. et al. Crohn’s disease in Tuzla region of Bosnia and Herzegovina: a 12-year study (1995–2006). Int J Colorectal Dis 23, 957–964 (2008). https://doi.org/10.1007/s00384-008-0493-1

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