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Survivin, p53, and Ki-67 as predictors of histopathologic response in locally advanced rectal cancer treated with preoperative chemoradiotherapy

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

The ability to predict response to chemoradiotherapy before the treatment may allow protecting poorly responding patients from the side effects of neoadjuvant treatment. Several molecular markers have been proposed to radio and chemosensitivity of rectal cancer. In this study, from pre-irradiation tumor biopsies, a novel and promising candidate factor survivin, and p53 and Ki-67 were assessed as predictors of response to preoperative chemoradiotherapy.

Materials and methods

Expression of each marker was evaluated by immunohistochemistry on pretreatment biopsies from 37 patients having rectal cancer treated with preoperative chemoradiotherapy and curative surgery. Treatment response was assessed histopathologically in the resected surgical specimen.

Results

There was no correlation between expression of p53, Ki-67, and survivin with response to preoperative chemoradiotherapy and prognosis.

Conclusions

Our data suggest that these molecular markers are not helpful to identify patients who would have benefit from neoadjuvant treatment of rectal cancer. Further investigations are necessary to select patients for preoperative treatment based on analysis of the preoperative biopsies.

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Author notes

  1. Cem Terzi

    Present address: , Vasif Cinar Blvd. No: 13/4 35220, Alsancak, Izmir, Turkey

Authors and Affiliations

  1. Department of Surgery, School of Medicine, Dokuz Eylul University, Izmir, Inciralti, 35340, Turkey

    Cem Terzi, Aras Emre Canda, Koray Atila & Mehmet Fuzun

  2. Department of Pathology, School of Medicine, Dokuz Eylul University, Izmir, Turkey

    Ozgul Sagol & Devrim Sonmez

  3. Department of Radiation Oncology, School of Medicine, Dokuz Eylul University, Izmir, Turkey

    Ilknur B. Gorken

  4. Department of Medical Oncology, School of Medicine, Dokuz Eylul University, Izmir, Turkey

    Ilhan Oztop

  5. Department of Radiology, School of Medicine, Dokuz Eylul University, Izmir, Turkey

    Funda Obuz

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  1. Cem Terzi
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Correspondence to Cem Terzi.

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Terzi, C., Canda, A.E., Sagol, O. et al. Survivin, p53, and Ki-67 as predictors of histopathologic response in locally advanced rectal cancer treated with preoperative chemoradiotherapy. Int J Colorectal Dis 23, 37–45 (2008). https://doi.org/10.1007/s00384-007-0376-x

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