Abstract
Background and aims
Patients with prolapsing internal hemorrhoids were treated with a novel sclerosing agent (OC-108), and the results were compared with surgery of ligation and excision.
Patients and methods
This study included 20 years or older patients with prolapsing internal hemorrhoids who visited ten medical institutions in Japan from October 2000 to October 2002. Investigation on surgery was also performed.
Results
Comparing OC-108 and surgery in patients with third- and fourth-degree internal hemorrhoids according to the Goligher’s classification, for which surgery has been generally indicated, at 28 days after treatment, the disappearance rate of prolapse was similar between OC-108 and surgery, 94% (75/80 patients) and 99% (84/85 patients), respectively. The 1-year recurrence rate was 16% (12/73 patients) in the OC-108 group, and this value was satisfactory because of its less invasive nature while it was more or less higher compared with 2% (2/81 patients) in the surgery group. The incidences of pain and bleeding were lower in the OC-108 group.
Conclusions
OC-108 is a useful alternative treatment for hemorrhoids.
Similar content being viewed by others
References
Santos G, Novell JR, Khoury G, Winslet MC, Lewis AA (1993) Long-term results of large-dose, single-session phenol injection sclerotherapy for hemorrhoids. Dis Colon Rectum 36:958–961
Sumikoshi Y, Okada M, Takano M, Matsushima Y, Kinugasa A, Koganezawa S et al (1971) Sclerotherapy of hemorrhoids—evaluation of the effect of Paoscle. J Jpn Soc Coloproctol 23:34–48
Takano M, Sakaue R, Fukushima Y, Kage M (1994) Experimental study on the effect of sclerosing agents for hemorrhoids. J Jpn Soc Coloproctol 47:140–151
Takamura H, Takano M, Ohba H, Fukano M, Iwadare J, Koganezawa S et al (2004) Investigation of efficacy, safety and pharmacokinetics with OC-108, a novel agent for sclerosing therapy of internal hemorrhoids—Early phase II study. Jpn Pharmacol Ther 32(6):355–365
Shi Z (1997) Xiaozhiling four-step injection in treating hemorrhoids of stages III and IV—a sclerotherapeutic approach of thrombosing branches of artery rectalis superior. Chin J Trad W Med 3:246–249
Takamura H, Inatsugu H, Yoshikawa S, Masuda T (2001) Treatment of internal hemorrhoids with Xiaozhiling injection. J Jpn Soc Coloproctol 54:910–914
Goligher J, Duthie H, Nixon H (eds) (1984) Haemorrhoids or piles: Surgery of the anus, rectum and colon, 5th edn. Baillière Tindall, London, pp 98–149
Acknowledgements
This study was supported by Mitsubishi Pharma Corporation, Japan.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Takano, M., Iwadare, J., Ohba, H. et al. Sclerosing therapy of internal hemorrhoids with a novel sclerosing agent. Int J Colorectal Dis 21, 44–51 (2006). https://doi.org/10.1007/s00384-005-0771-0
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00384-005-0771-0