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IgA nephropathy in association with Crohn’s disease

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Abstract

Background

Urological complications of inflammatory bowel disease are seen in up to 25% of patients, but renal parenchymal disease is rarely reported.

Case report

The authors describe a case of a 29-year-old man with clinical and radiological features of ileocaecal Crohn’s disease. He had previously been investigated for painless macroscopic haematuria and a renal biopsy had revealed IgA nephropathy. Despite medical treatment, regular exacerbations of Crohn’s disease were associated with deterioration in renal function and the development of haematuria. The patient eventually underwent surgical resection of the terminal ileum and caecum. His renal disease has remained quiescent for the last 5 years following resection.

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References

  1. Kyle J (1980) Urinary complications of Crohn’s disease. World J Surg 4:150–153

    Google Scholar 

  2. Shield DE, Lytton B, Weiss RM, Schiff M (1976) Urologic complications of inflammatory bowel disease. J Urol 115:701–706

    Google Scholar 

  3. McCallum D, Smith L, Harley F, Yiu V (1997) IgA nephropathy and thin basement membrane disease in association with Crohn’s disease. Pediatr Nephrol 11:637–640

    Google Scholar 

  4. Hirsch DJ, Kailash KJ, Trillo A, Cohen AD (1992) Acute renal failure in Crohn’s disease due to IgA nephropathy. Am J Kidney Dis 20:89–190

    Google Scholar 

  5. Hubert D, Beaufils M, Meyrier A (1984) Nephropathie glomerulaire à immunoglobulins A associée à une colite inflammatoire. Presse Med 13:1083–1085

    Google Scholar 

  6. Lopez BJM, Lafuente MP, Garcia CF, Ibarra PB, Diaz de Otazu R (1990) Crohn’s disease associated with Berger’s disease. A rare complication. Rev Esp Enferm Apar Dig 78:233–235

    Google Scholar 

  7. Takemura T, Okada M, Yagi K, Kuwajima H, Yanigada H (2002) An adolescent with IgA nephropathy and Crohn disease: pathogenetic implications. Pediatr Nephrol 17:863–866

    Google Scholar 

  8. Julian BA (2000) Treatment of IgA nephropathy. Semin Nephrol 20:277–285

    Google Scholar 

  9. Radford M, Donaldio J, Berstralh E, Grande J (1997) Predicting renal outcome in IgA nephropathy. J Am Soc Nephrol 8:199–207

    Google Scholar 

  10. Davlin JC, Forget P, Mahieu PR (1988) Increased intestinal permeability to (51Cr) EDTA is correlated with IgA immune complex—plasma levels in children with IgA-associated nephropathies. Acta Paediatr Scand 77:118–124

    Google Scholar 

  11. Nagy J, Scott H, Brandtzaeg P (1988) Antibodies to dietary antigens in IgA nephropathy. Clin Nephrol 29:275–279

    Google Scholar 

  12. Mahoney S, Anderson N, Nuki G, Ferguson A (1992) Systemic and mucosal antibodies to Klesiella in patients with ankylosing spondylitis and Crohn’s disease. Ann Rheum Dis 51:1296–1300

    Google Scholar 

  13. Imasawa T, Utsonomiya Y, Kawamura T, Nagasawa R, Maruyama N, Sakai O (1998) Evidence suggesting the involvement of haemopoietic stem cells in the pathogenesis of IgA nephropathy. Biochem Biophys Res Commun 249:605–611

    Google Scholar 

  14. Bouma G, Stober W (2003) The immunological and genetic basis of inflammatory bowel disease. Nat Rev 3:521–533

    Article  CAS  PubMed  Google Scholar 

  15. Das K (1999) Relationship of extraintestinal involvement in inflammatory bowel disease: new insights into autoimmune pathogenesis. Dig Dis Sci 44:1–13

    Google Scholar 

  16. Targan SR (2000) Biology of inflammation in Crohn’s disease: mechanisms of action of anti-TNFα therapy. Can J Gastroenterol 14:C13–C16

    Google Scholar 

  17. Altschuler EL (2001) Monoamine oxidase inhibitors for IgA nephropathy. Med Hypotheses 56:225–226

    Google Scholar 

  18. Friedman BI, Spray BJ, Heise ER (1994) HLA associations in IgA nephropathy and focal and segmental glomerulosclerosis. Am J Kidney Dis 23:352–357

    Google Scholar 

  19. Toyoda H, Wang SJ, Yang HJ (1993) Distinct associations of HLA class II genes with inflammatory bowel disease. Gastroenterology 104:741–748

    Google Scholar 

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Correspondence to M. J. Forshaw.

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Forshaw, M.J., Guirguis, O. & Hennigan, T.W. IgA nephropathy in association with Crohn’s disease. Int J Colorectal Dis 20, 463–465 (2005). https://doi.org/10.1007/s00384-004-0696-z

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  • DOI: https://doi.org/10.1007/s00384-004-0696-z

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