Skip to main content
SpringerLink
Log in

Effect of cyclosporine on fertility in male rats

  • ORIGINAL ARTICLE
  • Published:
Pediatric Surgery International Aims and scope Submit manuscript

Abstract

The effect of cyclosporine (CsA) on fertility has assumed greater importance with the increasing numbers of pediatric transplantations being performed all over the world. Conflicting reports on the effects of CsA on sex hormones are available. This experimental animal study was designed to examine the effect of CsA on testicular weight, sperm counts, seminiferous tubular diameter (STD), testicular morphology, DNA flowcytometry, sex hormone levels, and fertility in male rats. Those rats who received CsA (20 mg/kg per day) showed significant reductions in testicular weight (P < 0.05), sperm count (P < 0.01), Johnsen score (P < 0.05), STD (P < 0.01), serum testosterone levels (P < 0.05), haploid cell population (P < 0.001) in the testis, and fertility (P < 0.001) compared to those receiving CsA 10 mg/kg per day and control rats. These findings will have an important bearing for children receiving cyclosporine for long periods to guide the physician in optimally adjusting long-term treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi, India, , , , , , IN

    M. Srinivas, S. Agarwala & D. K. Mitra

  2. Department of Pathology, All India Institute of Medical Sciences, New Delhi, India, , , , , , IN

    S. Datta Gupta

  3. Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India, , , , , , IN

    S. N. Das

  4. Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, India, , , , , , IN

    P. Jha

  5. National Institute of Health and Family Welfare, New Delhi, India, , , , , , IN

    M. M. Misro

Authors
  1. M. Srinivas
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Agarwala
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Datta Gupta
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. N. Das
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. Jha
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. M. Misro
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. D. K. Mitra
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Accepted: 6 November 1997

Rights and permissions

Reprints and permissions

About this article

Cite this article

Srinivas, M., Agarwala, S., Datta Gupta, S. et al. Effect of cyclosporine on fertility in male rats. Pediatr Surg Int 13, 388–391 (1998). https://doi.org/10.1007/s003830050346

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s003830050346

Search

Navigation