Abstract
Purpose
This study aimed to evaluate the feasibility and safety of laparoscopic resection of abdominal neuroblastoma by comparing operative and long-term oncologic outcomes between open and laparoscopic surgeries.
Methods
This single-center retrospective study included patients who underwent laparoscopic tumor resection, between January 2000 and June 2021, with a maximum tumor diameter of ≤ 60 mm and without image-defined risk factors (IDRFs) at surgery. Data from 35 abdominal neuroblastoma resections were reviewed and compared between the laparotomy and laparoscopic groups.
Results
Nineteen patients underwent laparotomy and 16 had laparoscopic tumor resection. All laparoscopic surgeries achieved complete resection without conversion to open surgery. Median blood loss was significantly lower in the laparoscopic group (0.6 mL/kg) than in the laparotomy group (8.4 mL/kg) (P < 0.0001). There were two locoregional recurrences in the laparoscopic group and two metastatic recurrences in the laparotomy group. Five-year overall survival was 93.8% in both groups.
Conclusion
Laparoscopic resection of abdominal neuroblastomas in children is a feasible and safe procedure for tumors ≤ 60 mm in diameter with no IDRFs at surgery, with long-term outcomes equivalent to laparotomy.
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Data Availability
The data that support the fndings of this study are available from the corresponding author, M.Z., upon reasonable request.
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We would like to thank Editage (http://www.editage.com) for English language editing.
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All authors contributed to the conception and design of the study. Data collection and analysis were performed by MZ. The first draft of the manuscript was written by MZ. The draft was reviewed and edited by NU, and all authors commented on the second version of the manuscript. All authors read and approved the final manuscript.
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This study was performed in line with the principles of the Declaration of Helsinki. Study approval was granted by the institutional review board (IRB) of Osaka Women’s and Children’s Hospital (IRB number: 1567).
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Zenitani, M., Yoshida, M., Matsumoto, S. et al. Feasibility and safety of laparoscopic tumor resection in children with abdominal neuroblastomas. Pediatr Surg Int 39, 91 (2023). https://doi.org/10.1007/s00383-023-05371-8
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DOI: https://doi.org/10.1007/s00383-023-05371-8