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Histological features of complete tracheal rings in congenital tracheal stenosis

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Abstract

Purpose

Congenital tracheal stenosis is a disease in which complete tracheal cartilage rings (CTCR) cause airway narrowing. Although tracheal cartilage malformation has been suggested as a cause of CTCR, no histological studies have been performed. Here, we report a comparison of the tissues from CTCR and normal tracheal cartilage.

Methods

Thirty-one infants who underwent slide tracheoplasty at our institution from May 2016 to August 2019 were included. Tissues from ten autopsy cases without tracheal lesions were used as controls. The survey items were tracheal cartilage cell density, cartilage thickness, and chondrocyte findings.

Results

The median cartilage cell density from cases was 23/125 × 125 µm2 and from controls was 23.5/125 × 125 µm2 (p = 0.90). The median cartilage thickness from cases was 689 µm and from controls was 840 µm (p = 0.11). Comparing the ventral and dorsal sides of the CTCR tissues, the cell density was significantly different (median ventral 23/125 × 125 µm2; median dorsal 19.5/125 × 125 µm2; p = 0.034). There were no significant findings in the chondrocytes of the CTCR tissues.

Conclusion

CTCR tissues did not differ in cartilage density and thickness from normal tracheal cartilage.

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Acknowledgements

We are grateful to Dr. Makiko Yoshida of the Department of Pathology, Kobe Children’s Hospital, for advice and expertise.

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Pediatric Surgery, Kobe Children’s Hospital, 1-6-7, Minatojima Minami-cho, Chuo-ku, Kobe, 650-0047, Japan

    Yuki Fujieda, Keiichi Morita, Hiroaki Fukuzawa & Kosaku Maeda

Authors
  1. Yuki Fujieda
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  2. Keiichi Morita
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  3. Hiroaki Fukuzawa
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  4. Kosaku Maeda
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Contributions

Conceptualization and methodology: HF, KM; formal analysis, investigation and writing: YF, KM; supervision: KM.

Corresponding author

Correspondence to Yuki Fujieda.

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Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

This study has been approved by the institutional ethics committee (approval number: R31-23) and performed in line with the principles of the Declaration of Helsinki.

Informed consent

Since this study was widely open to the public, guaranteed a refusal to cooperate, and the data was anonymous, separate informed consent was waived.

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Fujieda, Y., Morita, K., Fukuzawa, H. et al. Histological features of complete tracheal rings in congenital tracheal stenosis. Pediatr Surg Int 37, 257–260 (2021). https://doi.org/10.1007/s00383-020-04803-z

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  • DOI: https://doi.org/10.1007/s00383-020-04803-z

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