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The protective effect of fish oil lipid emulsions on intestinal failure-associated liver disease in a rat model of short-bowel syndrome

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Abstract

Purpose

Pediatric patients with intestinal failure need long-term parenteral nutrition (PN), but this nutritional support causes liver dysfunction, such as intestinal failure-associated liver disease (IFALD). Several studies have shown that the lipid emulsion produced by soybean oil (SO) is associated with the occurrence of IFALD. In this study, we evaluated the effect of SO and fish oil (FO) lipid emulsion on hepatic steatosis.

Methods

Sprague-Dawley rats underwent jugular vein catheterization and were divided into three groups: sham operation with normal chow (Sham group), 80% small bowel resection (80% SBR) + TPN with SO lipid emulsion (SO group), and 80% SBR + TPN with FO lipid emulsion (FO group). All rats were euthanized and the serum biochemistry and hepatic histology analyzed.

Results

No significant differences in the serum liver or biliary enzymes were noted between the SO and FO groups. The pathological findings and NAFLD score in the FO group did not show steatosis and were significantly lower than in the SO group. An analysis of the fatty acids profile in the both the SO and FO groups did not indicate essential fatty acid deficiency (EFAD).

Conclusion

FO lipid emulsion may have a protective role against steatosis of IFALD without EFAD.

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Acknowledgements

We thank Brian Quinn for his comments and help with the manuscript. This study was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (Nos. 16K10466, 16K10094, 16K10095, 16K10434, 16H07090, 17K10555, 17K11514, 17K10183, 17K11515, and 17K10180).

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Authors and Affiliations

  1. Department of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan

    Seiro Machigashira, Tatsuru Kaji, Shun Onishi, Waka Yamada, Keisuke Yano, Koji Yamada, Ryuta Masuya, Takafumi Kawano, Kazuhiko Nakame, Motoi Mukai & Satoshi Ieiri

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  1. Seiro Machigashira
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  2. Tatsuru Kaji
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  3. Shun Onishi
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  4. Waka Yamada
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  5. Keisuke Yano
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  7. Ryuta Masuya
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  8. Takafumi Kawano
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  9. Kazuhiko Nakame
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  11. Satoshi Ieiri
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Corresponding author

Correspondence to Satoshi Ieiri.

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The authors declare no conflicts of interest in association with the present study.

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Machigashira, S., Kaji, T., Onishi, S. et al. The protective effect of fish oil lipid emulsions on intestinal failure-associated liver disease in a rat model of short-bowel syndrome. Pediatr Surg Int 34, 203–209 (2018). https://doi.org/10.1007/s00383-017-4190-4

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  • DOI: https://doi.org/10.1007/s00383-017-4190-4

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