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Primary pediatric cardiac malignancies: the SEER experience

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Abstract

Purpose

Pediatric cardiac malignancies are exceedingly rare. We sought to examine demographics, presentation, and outcomes for this pathology.

Methods

The SEER registry from 1973 to 2008 was queried for all patients <20 years of age with cardiac malignancies.

Results

A total of 25 pediatric patients were identified with primary cardiac malignancies, with age-adjusted incidence of 0.00686 per 100,000 United States population. Median age at diagnosis was 10 years. The majority of patients were adolescent (n = 13, 52 %), Caucasian (n = 17, 68 %) and males (n = 14, 56 %). The most common histology was soft tissue sarcoma (n = 10, 40%), followed by non-Hodgkin lymphoma and teratoma (both n = 3, 12 %). Six patients presented with distant disease. More than half of patients (n = 16, 64 %) underwent surgical resection, while four patients (16 %) underwent radiation. The mean survival time for the cohort was 47 ± 67 months, with 14 (56 %) patients dying over the study period. Lymphomas had significantly longer survival than other malignancies (108 ± 66 vs. 36 ± 66, p = 0.03), while lack of surgical treatment was associated with worse survival (p = 0.016).

Conclusions

Primary malignant cardiac tumors are exceedingly rare in pediatric patients. They are most commonly soft tissue sarcomas and lymphomas demonstrated longer survival.

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References

  1. Blondeau P (1990) Primary cardiac tumors–French studies of 533 cases. Thorac Cardiovasc Surg 38(Suppl 2):192–195

    Article  PubMed  Google Scholar 

  2. Gunther T, Schreiber C, Noebauer C, Eicken A, Lange R (2008) Treatment strategies for pediatric patients with primary cardiac and pericardial tumors: a 30-year review. Pediatr Cardiol 29:1071–1076

    Article  PubMed  Google Scholar 

  3. Molina JE, Edwards JE, Ward HB (1990) Primary cardiac tumors: experience at the University of Minnesota. Thorac Cardiovasc Surg 38(Suppl 2):183–191

    Article  PubMed  Google Scholar 

  4. Wang JN, Yao CT, Chen JS, Yang YJ, Tsai YC, Wu JM (2003) Cardiac tumors in infants and children. Acta Paediatr Taiwan 44:215–219

    PubMed  Google Scholar 

  5. Mariano A, Pita A, Leon R et al (2009) Primary cardiac tumors in children: a 16-year experience. Rev Port Cardiol 28:279–288

    PubMed  Google Scholar 

  6. Uzun O, Wilson DG, Vujanic GM, Parsons JM, De Giovanni JV (2007) Cardiac tumours in children. Orphanet J Rare Dis 2:11

    Article  PubMed  Google Scholar 

  7. Beghetti M, Gow RM, Haney I, Mawson J, Williams WG, Freedom RM (1997) Pediatric primary benign cardiac tumors: a 15-year review. Am Heart J 134:1107–1114

    Article  PubMed  CAS  Google Scholar 

  8. Aravot DJ, Banner NR, Cantor AM, Theodoropoulos S, Yacoub MH (1992) Location, localization and surgical treatment of cardiac pheochromocytoma. Am J Cardiol 69:283–285

    Article  PubMed  CAS  Google Scholar 

  9. Bader R, Hornberger LK, Nijmeh LJ et al (2006) Fetal pericardial teratoma: presentation of two cases and review of literature. Am J Perinatol 23:53–58

    Article  PubMed  Google Scholar 

  10. Neragi-Miandoab S, Kim J, Vlahakes GJ (2007) Malignant tumours of the heart: a review of tumour type, diagnosis and therapy. Clin Oncol 19:748–756

    Article  CAS  Google Scholar 

  11. Burke A, Virmani R (2007) Pediatric heart tumors. Cardiovasc Pathol 17:193–198

    Article  Google Scholar 

  12. Surveillance E, and End Results (SEER) Program (http://www.seer.cancer.gov/) SEER*Stat Database: Incidence SEER 9 Regs Limited-Use, Nov 2008 Sub (1973–2008) <Katrina/Rita Population Adjustment>–Linked To County Attributes—Total U.S., 1969–2006 Counties, National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April 2008, based on the November 2008 submission

  13. Liu L, Krailo M, Reaman GH, Bernstein L (2003) Childhood cancer patients’ access to cooperative group cancer programs: a population-based study. Cancer 97:1339–1345

    Article  PubMed  Google Scholar 

  14. Gutierrez JC, Fischer AC, Sola JE, Perez EA, Koniaris LG (2007) Markedly improving survival of neuroblastoma: a 30-year analysis of 1,646 patients. Pediatr Surg Int 23:637–646

    Article  PubMed  Google Scholar 

  15. Hogan AR, Zhuge Y, Perez EA, Koniaris LG, Lew JI, Sola JE (2009) Pediatric thyroid carcinoma: incidence and outcomes in 1,753 patients. J Surg Res 156:167–172

    Article  PubMed  Google Scholar 

  16. Kassira N, Pedroso FE, Cheung MC, Koniaris LG, Sola JE (2011) Primary gastrointestinal tract lymphoma in the pediatric patient: review of 265 patients from the SEER registry. J Pediatr Surg 46:1956–1964

    Article  PubMed  Google Scholar 

  17. Neville HL, Hogan AR, Zhuge Y et al (2009) Incidence and outcomes of malignant pediatric lung neoplasms. J Surg Res 156:224–230

    Article  PubMed  Google Scholar 

  18. Perez EA, Gutierrez JC, Koniaris LG, Neville HL, Thompson WR, Sola JE (2009) Malignant pancreatic tumors: incidence and outcome in 58 pediatric patients. J Pediatr Surg 44:197–203

    Article  PubMed  Google Scholar 

  19. McAllister HA, Fenogoio JJ (1978) Tumors of the cardiovascular system. Armed Forces Institute of Pathology, Washington DC

    Google Scholar 

  20. Petrich A, Cho SI, Billett H (2011) Primary cardiac lymphoma: an analysis of presentation, treatment, and outcome patterns. Cancer 117:581–589

    Article  PubMed  Google Scholar 

  21. Ceresoli GL, Ferreri AJ, Bucci E, Ripa C, Ponzoni M, Villa E (1997) Primary cardiac lymphoma in immunocompetent patients: diagnostic and therapeutic management. Cancer 80:1497–1506

    Article  PubMed  CAS  Google Scholar 

  22. Advani R (2011) Optimal therapy of advanced Hodgkin lymphoma. Hematol Am Soc Hematol Educ Progr 2011:310–316

    Article  Google Scholar 

  23. Miyake CY, Del Nido PJ, Alexander ME et al (2011) Cardiac tumors and associated arrhythmias in pediatric patients, with observations on surgical therapy for ventricular tachycardia. J Am Coll Cardiol 58:1903–1909

    Article  PubMed  Google Scholar 

  24. Kamiya H, Yasuda T, Nagamine H (2001) Surgical treatment of primary cardiac tumors: 28 years’ experience in Kanazawa University Hospital. Jpn Circ J 65:315–319

    Article  PubMed  CAS  Google Scholar 

  25. Ceithaml EL, Midgley FM, Perry LW, Dullum MK (1990) Intramural ventricular fibroma in infancy: survival after partial excision in 2 patients. Ann Thorac Surg 50:471–472

    Article  PubMed  CAS  Google Scholar 

  26. Rolla GA, Bertero MT, Pastena G (2002) Primary lymphoma of the heart. A case report and review of the literature. Leuk Res 26:117–120

    Article  PubMed  Google Scholar 

  27. Du XL, Key CR, Dickie L (2006) Information on chemotherapy and hormone therapy. J Clin Epidemiol 59:53–60

    Article  PubMed  Google Scholar 

  28. Shah SK, Fleet TM, Williams V, Smith AY, Skipper B, Wiggins C (2011) SEER coding standards result in underestimation of positive surgical margin incidence at radical prostatectomy: results of a systematic audit. J Urol 186:855–859

    Article  PubMed  Google Scholar 

  29. Shambaugh E (1991) Stat Bite Accuracy of SEER Data. J Natl Cancer Inst 83:1369

    Article  Google Scholar 

  30. Nathan H, Pawlik TM (2008) Limitations of Claims and Registry Data in Surgical Oncology Research. Ann Surg Oncol 15:415–423

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, University of Miami Miller School of Medicine, Miami, USA

    James S. Davis & Bassan J. Allan

  2. Division of Pediatric Surgery, Department of Surgery, University of Miami Miller School of Medicine, Clinical Research Building Suite 450 K, 1120 N.W. 14th Street, Miami, FL, 33136, USA

    Eduardo A. Perez, Holly L. Neville & Juan E. Sola

Authors
  1. James S. Davis
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  2. Bassan J. Allan
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  3. Eduardo A. Perez
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  4. Holly L. Neville
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  5. Juan E. Sola
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Corresponding author

Correspondence to Juan E. Sola.

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Davis, J.S., Allan, B.J., Perez, E.A. et al. Primary pediatric cardiac malignancies: the SEER experience. Pediatr Surg Int 29, 425–429 (2013). https://doi.org/10.1007/s00383-013-3261-4

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  • DOI: https://doi.org/10.1007/s00383-013-3261-4

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