Abstract
We describe two female neonates who suffered from four gastrointestinal anomalies, including duodenal stenosis or atresia, malrotation, segmental dilatation of the colon, and anorectal malformation. Each patient was managed by two or three operations, resulting in good bowel movements. Since this is the first report of four gastrointestinal anomalies, these cases may provide clues to elucidate the etiology of gastrointestinal tract developmental abnormalities.
References
Poenaru D, Uroz-Tristan J, Leclerc S, Murphy S, Bensoussan AL (1995) Imperforate anus, malrotation, and Hirschsprung’s disease: a rare association. Eur J Pediatr Surg 5:187–189
Andrassy RJ, Mahour GH (1979) Gastrointestinal anomalies associated with esophageal atresia or tracheoesophageal fistula. Arch Surg 114:1125–1128
Powell DM, Othersen HB, Smith CD (1989) Malrotation of the intestines in children: the effect of age on presentation and therapy. J Pediatr Surg 24:777–780
Mathur P, Mogra N, Surana SS, Bordia S (2004) Congenital segmental dilatation of the colon with anorectal malformation. J Pediatr Surg 39:E18–E20
Chadha R, Gupta S, Tanwar US, Mahajan JK (2001) Congenital pouch colon associated with segmental dilatation of the colon. J Pediatr Surg 36:1593–1595
Ngai RL, Chan AK, Lee JP, Mak CK (1992) Segmental colonic dilatation in a neonate. J Pediatr Surg 27:506–508
Helikson MA, Schapiro MB, Garfinkel DJ, Shermeta DW (1982) Congenital segmental dilatation of colon. J Pediatr Surg 17:201–202
Sarin YK, Singh VP (1995) Congenital segmental dilatation of colon. Ind Pediatr 32:116–118
Rizalar R, Sarac A, Gork AS, Somuncu S, Bernay F, Gurses N (1996) Duplication of appendix with segmental dilatation of the colon, myeloschisis and anal atresia. Eur J Pediatr Surg 6:112–113
Ramalho-Santos M, Melton DA, McMahon AP (2000) Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127:2763–2772
Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H, Beachy PA (1996) Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383:407–413
Belloni E, Muenke M, Roessler E, Traverso G, Siegel-Bartelt J, Frumkin A, Mitchell HF, Donis-Keller H, Helms C, Hing AV, Heng HH, Koop B, Martindale D, Rommens JM, Tsui LC, Scherer SW (1996) Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly. Nat Genet 14:353–356
Acknowledgments
The authors thank Paul D. Danielson, MD for reading the manuscript and helpful discussions.
Conflict of interest statement
There is no potential conflict of interest, and neither grants nor other form of payments were given to any authors.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Morikawa, N., Kuroda, T., Honna, T. et al. A novel association of duodenal atresia, malrotation, segmental dilatation of the colon, and anorectal malformation. Pediatr Surg Int 25, 1003–1005 (2009). https://doi.org/10.1007/s00383-009-2459-y
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00383-009-2459-y