Abstract
Inflammatory myofibroblastic tumor of the bladder is an uncommon condition of unknown neoplastic potential. In adults the tumor is seen in association with instrumentation of the lower genitourinary tract, while in children it appears to run an idiopathic course. Its clinical and radiological presentation in children resembles sarcoma. The case of a 10-year-old girl with inflammatory myofibroblastic tumor is presented, outlining the histological and immunhistochemical features to allow differentiation between sarcomas, the most important differential diagnosis. An outcome meta-analysis of the literature identified 35 cases of inflammatory myofibroblastic tumor in the bladder of children. Conservative surgery is the strategy of choice. There is no evidence of recurrence or metastasis at a median follow up of 1.5 years.
Similar content being viewed by others
References
Brunn H (1939) Two interesting benign lung tumors of contradictory histopathology. Remarks on the necessity for maintaining the chest tumor registry. J Thorac Cardiovasc Surg 9:119–131
Scott L, Blair G, Taylor G, Dimmick J, Fraser G (1988) Inflammatory pseudotumors in children. J Pediatr Surg 23:755–758
Stark GL, Fedderson R, Lowe BA, Benson CT, Black W, Borden TA (1988) Inflammatory pseudotumor (pseudosarcoma) of the bladder. J Urol 141:610–612
Albores-Saavedra J, Manivel JC, Essenfeld H, et al (1990) Pseudosarcomatous myofibroblastic proliferations in the urinary bladder of children. Cancer 66:1234–1241
Freud E, Bilik R, Yaniv I, et al (1991) Inflammatory pseudotumor in childhood a diagnostic and therapeutic dilemma. Arch Surg 126:653–655
Lamovec J, Zidar A, Tršinar B, Jančar J (1992) Sclerosing inflammatory pseudotumor of the urinary bladder in a child. Am J Surg Path 16:1233–1238
Angulo JC, Lopez JI, Flores N (1994) Pseudosarcomatous myofibroblastic proliferation of the bladder: report of 2 cases and literature review. J Urol 151:1008–1012
Hojo H, Newton WA, Hamoudi AB, et al (1995) Pseudosarcomatous myofibroblastic tumor of the urinary bladder in children: a study of 11 cases with review of the literature. Am J Surg Path 19:1224–1236
Foschini MP, Scarpellini F, Rinaldi P, Mancini AF, Accinelli G, Eusebi V (1995) Pseudotumore infiammatorio della vescica urinaria. Studio di 4 casi erivisione della letteratura. Pathologica 87:653–658
Lakshmanan Y, Willis ML, Gearhardt JP (1997) Inflammatory (pseudosarcomatous) myofibroblastic tumor of the bladder. Urol 50:285–288
Gardener MP, Lowichik A, Cartwright PC (1999) Inflammatory (pseudosarcomatous) myofibroblastic tumor of the urinary bladder causing acute abdominal pain. J Pediatr Surg 34:1417–1419
Meyer S, Bruce J, Kesley A, Eden OB (2000) Pseudosarcoma of the bladder associated with residual urachus in a 3-year-old girl. Pediatr Surg Int 16:604–606
Choi SK, Choi YD, Cheon SH, Byun Y, Cho SW (2000) Inflammatory pseudotumor of the urinary bladder in a child. Yonsei Med J 41:401–403
Mergan F, Jaubert F, Sauvat F, et al (2005) Inflammatory myofibroblastic tumor in children: clinical review with anaplastic lymphoma kinase, Epstein-Barr virus, and human herpesvirus 8 detection analysis. J Pediatr Surg 40:1581–1586
Coffin CM, Watterson J, Priest JR, Dehner LP (1995) Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 19:859–872
Jones EC, Clement PB, Young R (1993) Inflammatory pseudotumor of the urinary bladder. A clinicopathological, immunohistochemical, ultrastructural, and flow cytometric study of 13 cases. Am J Surg Pathol 17:264–274
Cook JR, Dehner LP, Collins MH, et al (2001) Anaplastic lymphoma kinase (ALK) expression in inflammatory myofibroblastic tumor. A comparative immunohistochemical study. Am J Surg Pathol 25:1364–1371
Freeman A, Geddes N, Munson P, et al (2004) Anaplastic lymphoma kinase (ALK 1) staining and molecular analysis in inflammatory myofibroblastic tumours of the bladder: a preliminary clinicopathological study of nine cases and review of the literature. Mod Pathol 17:765–771
Chan JKC, Cheuk W, Shimizu M (2001) Anaplastic lymphoma kinase expression in inflammatory pseudotumors. Am J Surg Pathol 25:761–768
Cessna MH, Zhou H, Sanger WG, et al (2002) Expression of ALK1 and p80 in inflammatory myofibroblastic tumor and its mesenchymal mimics: a study of 135 cases. Mod Pathol 15:931–938
Cessna MH, Zhou H, Perkins SL, et al (2001) Are myogenin and myoD1 expression specific for rhabdomyosarcoma? A study of 150 cases, with emphasis on spindle cell mimics. Am J Surg Pathol 25:1150–1157
Coyne JD, Wilson G, Sandu D, Young RH (1991) Inflammatory tumor of the urinary bladder. Histopath 18:261–264
Cole B, Zhou H, AcAllister N, Afify Z, Coffin CM (2006) Inflammatory myofibroblastic tumor with thrombocytosis and a unique chromosomal translocation with ALK rearrangement. Arch Pathol Lab Med 130:1042–1045
Janik JS, Janik JP, Lovell MA, Hendrickson RJ, Bensard DD, Greffe BS (2003) Recurrent inflammatory pseudotumors in children. J Ped Surg 38:491–1495
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Houben, C.H., Chan, A., Lee, K.H. et al. Inflammatory myofibroblastic tumor of the bladder in children: what can be expected?. Pediatr Surg Int 23, 815–819 (2007). https://doi.org/10.1007/s00383-007-1885-y
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00383-007-1885-y