Abstract
Gastrointestinal stromal tumors (GIST) are c-KIT positive neoplasm that occur predominantly in adults. A 13-year-old boy who presented with massive gastrointestinal hemorrhage was subsequently diagnosed with GIST of the stomach. The tumor originated from the lesser curvature with a narrow base and no infiltration into surrounding organs. Two metastatic lesions in the liver were also found. Total excision of the gastric lesion was performed followed by adjuvant imatinib mesylate chemotherapy. He has had no signs of recurrence during 8 months of follow-up. GIST in children are rare and their behavior is notoriously difficult to predict. We report our experience and review the literature.
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References
Miettinen M, Lasota J (2001) Gastrointestinal stromal tumors—definition, clinical, histological, immunohistochemical and molecular genetic features and differential diagnosis. Virchows Arch 438:1–12
Miettinen M, Aarlino-Rikala, Lasota J (1998) Gastrointestinal stromal tumors. Ann Chir Gynaecol 87:278–281
Haider N, Kader M, McDermott M, Devaney D, Corbally MT, Fitzgerald RJ (2004) Gastric stromal tumors in children. Pediatr Blood Cancer 42:186–189
Hughes JA, Cook JV, Said A, Chong SK, Towu E, Reidy J (2004) Gastrointestinal stromal tumor of the duodenum in a 7-year-old boy. Pediatr Radiol 34:1024–1027
DeMatteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff J, Brennan MF (2000) Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic patterns for survival. Ann Surg 231:51–58
Cypriano MS, Jenkins JJ, Pappo AS, Rao BN, Daw NC (2004) Pediatric gastrointestinal stromal tumors and leiomyosarcoma. Cancer 101:39–50
Li P, Wei J, West AB, Perle M, Greco MA, Yang GC (2002) Epithelioid gastrointestinal stromal tumor of the stomach with liver metastases in a 12-year-old girl: aspiration cytology and molecular study. Pediatr Dev Pathol 5:386–394
Terada R, Ito S, Akama F, Kidogawa H, Ichikawa K, Ooe H (2000) Clinical and histopathological features of colonic stromal tumor in a child. J Gastroenterol 35:456–459
Kerr JZ, Hicks MJ, Nuchtern JG, Saldivar V, Heim-Hall J, Shah S, Kelly DR, Cain WS, Chintagumpala MM (1999) Gastrointestinal autonomic nerve tumors in the pediatric population: a report of four cases and a review of the literature. Cancer 85:220–230
Wu SS, Buchmiller TL, Close O, Gershman GB, Peng S, French SW (1999) Congenital gastrointestinal pacemaker cell tumor. Arch Pathol Lab Med 123:842–845
Varan A, Doganc T, Taskin M, Uner A, Varan B (2000) gastrointestinal autonomic nerve tumor: the youngest case reported in the literature. J Pediatr Gastroenterol Nutr 31:183–184
Durham MM, Gow KW, Shehata BM, Katzenstein HM, Lorenzo RL, Ricketts RR (2004) Gastrointestinal stromal tumors arising from the stomach: a report of three children. J Pediatr Surg 39:1495–1499
Shenoy MU, Singh SJ, Robson K, Stewart RJ (2000) Gastrointestinal stromal tumor: a rare cause of neonatal intestinal obstruction. Med Pediatr Oncol 34:70–71
Jollimore JV, Zamalhashary M, Giacomantonio M, Yu W (2003) Undifferentiated Mesenchymal neoplasm of the esophagus in a child: case report and comparison with gastrointestinal stromal tumor. Pediatr Dev Pathol 6:257–260
Karnak I, Kale G, Tanyel FC, Buyukpamuku N (2003) Malignant stromal tumor of the colon in an infant: diagnostic difficulties and differential diagnosis. J Pediatr Surg 38:245–247
Lauwers GY, Erlandson RA, Casper ES, Brennan MF, Woodruff JM (1993) Gastrointestinal autonomic nerve tumors: a clinicopathologic, immunohistochemical and ultrastructural study of 12 cases. Am J Surg Pathol 17:887–897
Miettinen M, Majidi M, Lasota J (2002) Pathology and diagnostic criteria of gastrointestinal stromal tumors (GIST): a review. Eur J Cancer 38:S39–S51
Fletcher CD, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, Miettinen M, Oȁ9Leary TJ, Remotti H, Rubin Brian P, Shmookler Barry, Sobin LH, Weiss Sharon W (2002) Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol 33:459–465
Pierie J-PEN, Choudry U, Muzikansky A, Beow YY, Wiley WS, Mark JO (2001) The effect of surgery and grade on outcome of gastrointestinal stromal tumors. Arch Surg 136:383–389
Wu P, Langerman A, Ryan CW, Hart J, Swiger S, Mitchell CP (2003) Surgical treatment of gastrointestinal stromal tumors in the imatinib (STI-571) era. Surgery 134:656–666
Savage DG, Antman KH (2002) Imatinib mesylate—a new oral targeted therapy. N Eng J Med 346:683–693
Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, Heinrich MC, Tuveson DA, Singer S, Janicek M, Fletcher JA, Silverman SG, Silberman SL, Capdeville R, Kiese B, Peng B, Dimitrijevic S, Druker BJ, Corless C, Fletcher CD, Joensuu H (2002) Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Eng J Med 347:472–480
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Hayashi, Y., Okazaki, T., Yamataka, A. et al. Gastrointestinal stromal tumor in a child and review of the literature. Ped Surgery Int 21, 914–917 (2005). https://doi.org/10.1007/s00383-005-1511-9
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DOI: https://doi.org/10.1007/s00383-005-1511-9