Abstract
Ovarian fibroma rarely occurs in prepubertal girls. We report an ovarian fibroma in a 7-month-old female infant presenting as a right abdominal mass. The tumour was composed of oval-to-spindle cells forming interlacing fascicles and intermingling with collagen fibres. Immunohistochemically, the tumour cells were weakly positive for estrogen receptor and progesterone receptor but negative for inhibin. To the best of our knowledge, this is the youngest case of ovarian fibroma up-to-date in the English literature. Because Gorlin’s syndrome was not present in the patient’s family, other factors such as germline or somatic mutations may predispose the occurrence of this ovarian fibroma in infancy.
Similar content being viewed by others
References
Dockerty MB, Masson JC (1944) Ovarian fibromas: a clinical and pathologic study of two hundred and eighty-three cases. Am J Obstet Gynecol 47:741–752
Ehren IM, Mahour GH, Isaacs JH (1984) Benign and malignant ovarian tumours in children and adolescents: a review of 63 cases. Am J Surg 147:339–344
Johnson AD, Hebert A, Esterly NB (1986) Nevoid basal cell carcinoma syndrome: bilateral ovarian fibromas in a 31/2 -year-old girl. J Am Acad Dermatol 14:371–374
Charache H (1959) Ovarian tumours in childhood. AMA Arch Surg 79:573–580
Meigs JV (1954) Fibroma of the ovary with ascites and hydrothorax—Meigs’ syndrome. Am J Obstet Gynecol 67:962
Gorlin RJ (1987) Nevoid basal-cell carcinoma syndrome. Medicine 66:98–113
Gorlin RJ, Vickers RA, Kelln E, et al. (1965) The multiple basal cell nevi syndrome. Cancer 18:89–104
Gailani MR, Bale S, Leffell DJ (1992) Developmental defects in Gorlin syndrome related to a putative tumour suppressor gene on chromosome 9. Cell 69:111–117
Bower J, Erickson ER (1967) Bilateral ovarian fibromas in a 5-year-old. Am J Obstet Gynecol 99:880–882
Hahn H, Wicking C, Zaphiropoulos PG, et al. (1996) Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85:841–851
Johnson RL, Rothman AL, Xie J, et al. (1996) Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 272:1668–1671
Stone DM, Hynes M, Armanini M, et al. (1996) The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384:129–134
Hahn H, Wojnowski L, Miller G, et al. (1999) The patched signaling pathway in tumorigenesis and development: lessons from animal models. J Mol Med 77:459–468
Cohen MM, Jr (1999) Nevoid basal cell carcinoma syndrome: molecular biology and new hypotheses. Int J Oral Maxillofac Surg 28:216–223
Rater CJ, Selke AC, Van Epps EF (1968) Basal cell nevus syndrome. Am J Roentgenol 103:589–594
Junaid TA, Nkposong EO, Kolawole TM (1972) Cutaneous meningiomas and an ovarian fibroma in a three-year-old girl. J Pathol 108:165–167
Dumont-Herskowitz RA, Safaii HS, Senior B (1978) Ovarian fibromata in four successive generations. J Pediatr 93:621–624
Raggio M, Kaplan AL, Harberg JF (1983) Recurrent ovarian fibromas with basal cell nevus syndrome (Gorlin syndrome). Obstet Gynecol 61(suppl):95–96
Howell CJ, Rogers DA, Gable DS (1990) Bilateral ovarian fibromas in children. J Pediatr Surg 25:690–691
Laufer L, Barki Y, Mordechai Y, et al. (1996) Ovarian fibroma in a prepubertal girl. Pediatr Radiol 26:40–42
Young RH, Scully RE (1988) Ovarian sex cord-stromal tumours: problems in differential diagnosis. Pathol Ann 23:237–296
Amin HK, Okagaki T, Richart RM (1971) Classification of fibroma and thecoma of the ovary: an ultrastructural study. Cancer 27:438–446
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Chen, YJ., Hsieh, CS., Eng, HL. et al. Ovarian fibroma in a 7-month-old infant: a case report and review of the literature. Ped Surgery Int 20, 894–897 (2004). https://doi.org/10.1007/s00383-004-1284-6
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00383-004-1284-6