Abstract
Recent advances in neurosurgical techniques and diagnostic imaging capabilities have facilitated gross total resection and accurate staging of disease extent in a greater proportion of patients. The addition of chemotherapy to surgery and craniospinal radiation has improved the outcome of patients diagnosed with medulloblastoma. Long-term follow-up studies have documented the neuroendocrine and neuropsychological deficits seen in the survivors. This paper reviews key studies using all three modalities over the past two decades and presents on-going therapeutic strategies using a risk-adapted approach. Further areas of basic research and evolving data on studies in relapsed patients are also briefly discussed.
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Received: 12 April 1999
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Gajjar, A., Kühl, J., Epelman, S. et al. Chemotherapy of medulloblastoma. Child's Nerv Syst 15, 554–562 (1999). https://doi.org/10.1007/s003810050543
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DOI: https://doi.org/10.1007/s003810050543