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Neuroendoscopic lavage for the treatment of pyogenic ventriculitis in children: personal series and review of the literature

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Abstract

Introduction

Pyogenic ventriculitis is a severe infection of the central nervous system with serious and often irreversible consequences in the quality of life of patients. Its treatment is difficult due to the impossibility of achieving sterility of cerebrospinal fluid (CSF) and the physiological characteristics promptly. Several treatment options have been described, from prolonged antibiotic treatments to placement of ventricular drains with continuous irrigation and puncture reservoirs. We propose an aggressive and minimally invasive treatment with neuroendoscopic lavage (NEL).

Methods

Retrospective and descriptive study. We analyzed the NEL performed in our hospital for pyogenic ventriculitis between 2011 and 2020. A total of 16 patients were found; 2 of them lost follow-up, so they were not included. All patients had a diagnosis of pyogenic ventriculitis, either due to the macroscopic characteristics of the CSF or due to imaging criteria. Between 1 and 3 NEL were performed per patient until obtaining sterility and normalization of protein and cell counts of CSF.

Results

The average age was 38 months (2 months to 16 years). Ten patients were female and 4 were male. Sixty-four percent of germs in cultures corresponded to gram-negative and polymicrobial flora. The average number of days until the first sterile CSF post-NEL was 3.8 days (0 to 10 days). The NEL produced a significant improvement in the characteristics of the CSF compared to the pre-NEL. The mean pre-NEL of CSF protein levels was 907 mg/dl (123–4510 mg/dl) compared with the post-NEL of 292 mg/dl (38–892 mg/dl) with a p-value = 0.0076. Regarding cellularity, statistically significant results were also achieved (p-value = 0.0011) with a pre-surgical cellularity of 665 elements/mm3 (4–3090 elements/mm3) compared with 57 elements/mm3 (0–390 elements/mm3) post-NEL.

Of the patients, 85.7% had a shunt prior to the onset of ventriculitis and the average number of days until the new shunt was 36.56 days (17–79 days), with a total hospitalization days ranging from 22 to 170.

Conclusions

NEL allows rapid sterilization of CSF, decreasing the deleterious effect of infection in the CNS more rapidly compared to other types of conventional treatment.

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Authors and Affiliations

  1. Division of Pediatric Neurosurgery, Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Argentina

    Adalberto Ochoa, Romina Argañaraz & Beatriz Mantese

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  1. Adalberto Ochoa
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  2. Romina Argañaraz
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  3. Beatriz Mantese
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Correspondence to Adalberto Ochoa.

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This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Garrahan’s Pediatric Hospital.

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Ochoa, A., Argañaraz, R. & Mantese, B. Neuroendoscopic lavage for the treatment of pyogenic ventriculitis in children: personal series and review of the literature. Childs Nerv Syst 38, 597–604 (2022). https://doi.org/10.1007/s00381-021-05413-3

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