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Decreased natural killer cells in diffuse intrinsic pontine glioma patients

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Abstract

Purpose

Diffuse intrinsic pontine glioma (DIPG) remains the leading cause of death among pediatric brain tumor patients. Its pontine location and aggressive nature make developing effective treatment an ongoing challenge in pediatric oncology. Although studies have found that one of the hallmark features of glioma is immunosuppression, the immune status of DIPG patient is not clearly understood.

Methods

We tested the lymphocyte profile in four radiologically diagnosed DIPG patients. All the four patients did not receive any steroids, radiotherapy, and chemotherapy before the collection of blood.

Results

We found decreased natural killer (NK) cell level and increased B cell level in all four cases.

Conclusion

These findings suggested that decreased NK cells and increased B cells may aid the tumorigenesis and growth seen in DIPG patient. Increased NK and decreased B cells may be the future direction for the treatment of DIPG patient.

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References

  1. Lieberman NAP, DeGolier K, Kovar HM et al (2019) Characterization of the immune microenvironment of diffuse intrinsic pontine glioma: implications for development of immunotherapy. Neuro Oncol. 21(1):83–94

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Authors and Affiliations

  1. Department of Neurosurgery, Shengjing Hospital of China Medical University, # 36 Heping District, Shenyang City, 110004, Liaoning Province, China

    Lei Zhang, Hongwei Yu & Yunhui Liu

  2. Liaoning Research Center for Translational Medicine in Nervous System Disease, Shenyang, China

    Lei Zhang & Yunhui Liu

  3. Key Laboratory of Neuro-Oncology in Liaoning Province, Shenyang, China

    Lei Zhang & Yunhui Liu

  4. Department of Neurobiology, School of Life Sciences, China Medical University, Shenyang, China

    Yixue Xue

Authors
  1. Lei Zhang
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  2. Hongwei Yu
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  3. Yixue Xue
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  4. Yunhui Liu
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Corresponding author

Correspondence to Yunhui Liu.

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Zhang, L., Yu, H., Xue, Y. et al. Decreased natural killer cells in diffuse intrinsic pontine glioma patients. Childs Nerv Syst 36, 1345–1346 (2020). https://doi.org/10.1007/s00381-020-04665-9

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  • DOI: https://doi.org/10.1007/s00381-020-04665-9

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