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Cerebellar mutism syndrome: current approaches to minimize risk for CMS

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Abstract

Purpose

Cerebellar mutism syndrome (CMS) is a serious source of morbidity following posterior fossa surgery in the pediatric population. However, methods for effectively decreasing its incidence and impact remain unclear. It is our aim to examine the impact of adjusting surgical factors, namely the use of a telovelar approach and avoidance of cavitronic ultrasonic aspirator, on the incidence of CMS in our population as well as outlining potential pre-, intra-, and postoperative factors that may contribute to its development.

Methods

Retrospective review was performed to identify patients undergoing posterior fossa surgery for resection of a medulloblastoma. Demographic, surgical, and postoperative data were collected. These data were analyzed for possible correlations to the risk of developing CMS via univariate analysis. For factors found to be significant, a multivariate analysis was performed to assess their independence.

Results

Seven of 65 patients (10.8%) developed CMS postoperatively. Factors found to be significantly associated with a higher risk of CMS were the degree of retraction utilized during the procedure (p = 0.0000) and incision of the vermis (p = 0.0294). Although they did not reach the threshold of statistical significance, tumor vascularity (p = 0.19), adoption of a transvermian approach (p = 0.19), and lack of intraoperative imaging (p = 0.17) exhibited strongly suggestive trends towards a correlation with CMS.

Discussion

In an effort to reduce the incidence and severity of CMS in our population, our institution adopted surgical practices that minimize tissue trauma and mitigate postoperative edema. This included the use of a telovelar over a transvermian approach to obviate the need for vermian incision, avoidance of the CUSA, and minimization of heavy retraction during surgery. This was successful in reducing the incidence of CMS from 39% in our medulloblastoma patients to 10.8%. The development of CMS after posterior fossa surgery appears to be a “two-hit” phenomenon requiring a combination of existing predisposition, surgical injury, and postoperative exacerbation. Therefore, it is critical to identify the factors involved at each stage and investigate treatments to target them appropriately.

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Authors and Affiliations

  1. Division of Neurosurgery, Children’s National Medical Center, 4th Floor, Suite 100, 111 Michigan Ave NW, Washington, DC, 20010, USA

    Kelsey Cobourn, Fares Marayati, Deki Tsering, Owen Ayers, John S. Myseros, Suresh N. Magge, Chima O. Oluigbo & Robert F. Keating

  2. Georgetown University School of Medicine, Washington, DC, USA

    Kelsey Cobourn

  3. Princeton University, Princeton, NJ, USA

    Fares Marayati & Owen Ayers

  4. George Washington University School of Medicine, Washington, DC, USA

    John S. Myseros, Suresh N. Magge, Chima O. Oluigbo & Robert F. Keating

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  1. Kelsey Cobourn
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Cobourn, K., Marayati, F., Tsering, D. et al. Cerebellar mutism syndrome: current approaches to minimize risk for CMS. Childs Nerv Syst 36, 1171–1179 (2020). https://doi.org/10.1007/s00381-019-04240-x

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