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Cerebrospinal fluid neuron specific enolase, interleukin-1β and erythropoietin concentrations in children after seizures

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Abstract

Purpose

In the present study, the levels of neuron-specific enolase (NSE), interleukin-1β (IL-1β), and erythropoietin (EPO) in cerebrospinal fluid (CSF) in children with idiopathic epilepsy were measured to illuminate the relationships between these markers with idiopathic epilepsy.

Methods

Eighty-five children from 6 months to 12.5 years of age with single, previously undiagnosed, and untreated idiopathic epilepsy were participated in this study. The concentrations of CSF NSE, 1L-1β, and EPO were measured by specific ELISA methods.

Results

The mean concentrations of CSF NSE, IL-1β, and EPO in the epileptic groups showed a significant increase (P < 0.01) compared with those in the control groups. Besides, the mutual correlations of NSE, 1L-1β, and EPO were also analyzed. Results showed that there were positive correlations between the levels of IL-1β, NSE, and EPO.

Conclusions

The changes of NSE, 1L-1β, and EPO level in CSF may be beneficial for the pathophysiology study of epileptic seizures and the identification and diagnosis of a seizure clinically.

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Authors and Affiliations

  1. Department of Pediatric Neurology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People’s Republic of China

    Ling-min Shi & Jian Gong

  2. Department of Pharmacy, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People’s Republic of China

    Rui-jie Chen & Hui Zhang

  3. Department of Pediatrics, Hangzhou First People’s Hospital, Nanjing Medical University, Hangzhou, 301103, Zhejiang, People’s Republic of China

    Chun-ming Jiang

  4. Medical Laboratory Center, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People’s Republic of China

    Jian Gong

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  1. Ling-min Shi
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Correspondence to Jian Gong.

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Shi, Lm., Chen, Rj., Zhang, H. et al. Cerebrospinal fluid neuron specific enolase, interleukin-1β and erythropoietin concentrations in children after seizures. Childs Nerv Syst 33, 805–811 (2017). https://doi.org/10.1007/s00381-017-3359-4

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  • DOI: https://doi.org/10.1007/s00381-017-3359-4

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