Skip to main content

Advertisement

SpringerLink
Log in

Progression of Chiari I malformations while on growth hormone replacement: a report of two cases

  • Case Report
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

Purpose

The effect of growth hormone replacement on Chiari I malformation (CIM) associated with growth hormone deficiency is not clear.

Case reports

Two patients are presented, who were found to have CIM and growth hormone deficiency. While on hormone replacement therapy, both experienced disease progression with development of syringomyelia and required surgical intervention.

Conclusion

Growth hormone replacement for CIM associated with growth hormone deficiency does not uniformly halt or reverse syrinx progression. If a trial of hormone replacement is attempted, patients should be followed closely for progression of syringomyelia or the development of symptoms.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Gupta A, Vitali AM, Rothstein R, Cochrane DD (2008) Resolution of syringomyelia and Chiari malformation after growth hormone therapy. Childs Nerv Syst 24:1345–1348

    Article  PubMed  Google Scholar 

  2. Mori Y, Deguchi A, Tsuda M, Nagano T, Wada H, Tanaka I, Deguchi K, Shirakawa S (1987) A case of pituitary dwarfism with hyperlipemia, factor XII and XI deficiency, and low level of NK activity. Nihon Naika Gakkai zasshi J Jap Soc Int Med 76:1078–1082

    Article  CAS  Google Scholar 

  3. O’Grady MJ, Cody D (2011) Symptomatic Chiari 1 malformation after initiation of growth hormone therapy. J Pediatr 158:686

    Article  PubMed  Google Scholar 

  4. Takakuwa S, Asai A, Igarashi N (1996) A case of syringomyelia with type I Arnold-Chiari malformation (ACM): growth hormone (GH) therapy and the size of syrinx on serial MR images. Endocr J 43(Suppl):S129–130

    Article  PubMed  Google Scholar 

  5. Tubbs RS, Wellons JC 3rd, Smyth MD, Bartolucci AA, Blount JP, Oakes WJ, Grabb PA (2003) Children with growth hormone deficiency and Chiari I malformation: a morphometric analysis of the posterior cranial fossa. Pediatr Neurosurg 38:324–328

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Children’s of Alabama, Birmingham, AL, USA

    Robert P. Naftel, R. Shane Tubbs, Joshua Y. Menendez & W. Jerry Oakes

  2. Pediatric Neurosurgery, Children’s Hospital, 1600 7th Ave S, ACC 400, Birmingham, 35233, AL, USA

    R. Shane Tubbs

Authors
  1. Robert P. Naftel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Shane Tubbs
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Joshua Y. Menendez
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. W. Jerry Oakes
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to R. Shane Tubbs.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Naftel, R.P., Tubbs, R.S., Menendez, J.Y. et al. Progression of Chiari I malformations while on growth hormone replacement: a report of two cases. Childs Nerv Syst 29, 2291–2294 (2013). https://doi.org/10.1007/s00381-013-2080-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00381-013-2080-1

Keywords

Search

Navigation