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Desmoplastic infantile astrocytoma: recurrence with malignant transformation into glioblastoma: a case report

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Abstract

Desmoplastic infantile astrocytoma (DIA) is an uncommon brain tumor of early infancy. The tumor is characterized by a lobar location, glial histology, and excellent prognosis after surgical removal. DIA and a similar tumor, desmoplastic infantile ganglioglioma (DIG) have been considered to be benign neoplasms, but the prognosis of DIA and DIG is currently under question as atypical and aggressive clinical features of the tumors have been reported. We encountered a patient who was diagnosed with DIA at the age of 22 months and exhibited tumor recurrence 8 years later. Surgical removal of the recurred tumor revealed that the tumor had transformed to overt glioblastoma. This case demonstrates that DIA is not an absolutely benign tumor and that careful clinical surveillance is needed during the follow-up period.

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Acknowledgement

This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (0520300).

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Authors and Affiliations

  1. Division of Pediatric Neurosurgery, Seoul National University Children’s Hospital, 101 Daehakro, , Jongno-gu, Seoul, 110-744, Republic of Korea

    Ji Hoon Phi, Eun Jung Koh, Seung-Ki Kim, Byung-Kyu Cho & Kyu-Chang Wang

  2. Department of Pathology, Seoul National University Children’s Hospital, Seoul National University, Seoul, Republic of Korea

    Sung-Hye Park

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  1. Ji Hoon Phi
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  2. Eun Jung Koh
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  3. Seung-Ki Kim
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  4. Sung-Hye Park
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Correspondence to Ji Hoon Phi.

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Phi, J.H., Koh, E.J., Kim, SK. et al. Desmoplastic infantile astrocytoma: recurrence with malignant transformation into glioblastoma: a case report. Childs Nerv Syst 27, 2177–2181 (2011). https://doi.org/10.1007/s00381-011-1587-6

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  • DOI: https://doi.org/10.1007/s00381-011-1587-6

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