Abstract
Background
Retinoblastoma is the most common pediatric intraocular neoplasm. The association of uni- or bilateral retinoblastoma with synchronic or metachronic ectopic midline intracranial tumor [trilateral retinoblastoma (TRB)] is uncommon.
Materials and methods
MR examinations of 202 children with retinoblastoma treated at our institute were retrospectively reviewed. MR images and clinical data of children with TRB were evaluated for the patient’s age at diagnosis of the intracranial tumor and intraocular lesions, tumor size, signal characteristics, and further course in follow-up MR examinations.
Results
There were three patients with TRB in our group of patients. All three children had had a negative family history. Two of them had a primary midline intracranial tumor and intraocular lesions at the time of the first diagnosis. In the third case, the first diagnosis was intracranial midline primitive neuroectodermal tumor. Diagnosis of lesions in both eyes was confirmed in ophthalmologic examination 1 month later. In one case, the intracranial tumor was in the pineal region and, in the other two cases, in the sellar and suprasellar regions. There was no evidence of leptomeningeal spread of the tumors in any patient.
Conclusions
Patients with uni- and bilateral intraocular tumors should receive brain screening by MR imaging. We also recommend that patients under the age of 4 years with midline tumors should be carefully diagnosed for ocular neoplasms.
Similar content being viewed by others
References
Provenzale JM, Gururangan S, Klintworth G (2004) Trilateral retinoblastoma: clinical and radiologic progression. Am J Roentgenol 183(2):505–511
Friend SH, Bernards R, Rogelj S, Weinberg RA, Rapaport JM, Albert DM, Dryja TP (1986) A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 323:643–646
Cho EY, Suh Y-L, Shin H-J (2002) Trilateral retinoblastoma: a case report. J Korean Med Sci 17:137–140
Jakobiec FA, Tso MO, Zimmerman LE, Danis P (1977) Retinoblastoma and intracranial malignancy. Cancer 39(5):2048–2058
Bader JL, Miller RW, Meadows AT, Zimmerman LE, Champion LA, Voute PA (1980) Trilateral retinoblastoma. Lancet 2:582–583
Bagley LJ, Hurst RW, Zimmerman RA, Shields JA, Shields CL, De Potter P (1996) Imaging in the trilateral retinoblastoma syndrome. Neuroradiology 38:166–170
Katayama Y, Tsubokawa T, Yamamoto T, Nemoto N (1991) Ectopic retinoblastoma within the 3rd ventricle: case report. Neurosurgery 28:158–161
Bejjani GK, Donahue DJ, Selby D, Cohen PH, Packer R (1996) Association of a suprasellar mass and intraocular retinoblastoma: a variant of pineal trilateral retinoblastoma? Pediatr Neurosurg 25:269–275
Finelli DA, Shurin SB, Bardenstein DS (1995) Trilateral retinoblastoma: two variations. AJNR Am J Neuroradiol 16:166–170
Provenzale JM, Weber A, Klintworth GK, McLendon RE (1995) Radiologic-pathologic correlation. Bilateral retinoblastoma with coexistent pinealoblastoma (trilateral retinoblastoma). AJNR 16:157–165
Mouratova T (2005) Trilateral retinoblastoma: a literature review, 1971–2004. Bull Soc Belge Ophtalmol 297:25–35
Kivelä T (1999) Trilateral retinoblastoma: a meta-analysis of hereditary retinoblastoma associated with primary ectopic intracranial retinoblastoma. J Clin Oncol 17(6):1829–1837
Amoaku WMK, Willshaw HE, Parkes SE, Shah KJ, Mann JR (1996) Trilateral retinoblastoma: a report of five patients. Cancer 78:858–863
Ibarra MS, O'Brien JM (2000) Is screening for primitive neuroectodermal tumours in patients with unilateral retinoblastoma necessary? JAAPOS 4:54–56
Paulino AC (1999) Trilateral retinoblastoma: is the location of the intracranial tumour important? Cancer 86:135–141
De Potter P, Shields CL, Shields JA (1994) Clinical variations of trilateral retinoblastoma: a report of 13 cases. J Pediatr Ophthalmol Strabismus 31:26–31
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Jurkiewicz, E., Pakuła-Kościesza, I., Rutynowska, O. et al. Trilateral retinoblastoma: an institutional experience and review of the literature. Childs Nerv Syst 26, 129–132 (2010). https://doi.org/10.1007/s00381-009-0958-8
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00381-009-0958-8