Abstract
Background
Computed tomography (CT) findings in children with tuberculous meningitis (TBM) often do not explain the clinical presentation and may even be normal. Magnetic resonance imaging (MRI) has the potential to diagnose TBM with greater sensitivity than CT and also to detect more infarcts.
Aim
The aim of this study was to determine whether MRI demonstrates features and complications of TBM not present on CT.
Materials and methods
Retrospective, blinded evaluation and comparison of CT and MRI findings in children with TBM were performed.
Results
Of 30 children included, MRI demonstrated eight more with basal enhancement and four more with infarctions. Overall, MRI demonstrated an additional 104 sites of infarction (of a total 172) than CT. Of these, 89 were acute and visualized only on diffusion-weighted image. MRI showed five more patients with unilateral and two more with bilateral basal ganglia infarcts than CT as well as 19 brainstem infarcts. Hydrocephalus was equally detected by MRI and CT.
Conclusion
MRI is superior to CT for diagnosing TBM (by detecting basal enhancement in more patients) and prognosis (by detecting many more infarcts in strategic locations). The role of CT is defined for the acute setting in detecting hydrocephalus for surgical management.
Similar content being viewed by others
References
Przybojwski S, Andronikou S, Wilmshurst J (2006) Objective CT criteria to determine the presence of abnormal basal enhancement in children with suspicious tuberculous meningitis. Pediatr Radiol 36:687–696
Andronikou S, Wieselthaler N (2004) Modern imaging of tuberculosis in children: thoracic, central nervous system and abdominal tuberculosis. Pediatr Radiol 34:861–875
Bernaerts A, Vanhoenacker FM, Parizel PM, van Goethem JW, van Altena R, Laridon A, de Roeck J, Coeman V, de Schepper AM (2003) Tuberculosis of the central nervous system: overview of neuroradiological findings. Eur Radiol 13:1876–1890
Schoeman CJ (1990) The epidemiology and outcome of childhood tuberculous meningitis. The Pelonomi Hospital experience. S Afr Med J 78(5):245–247
Berman S, Kibel MA, Fourie PB, Strebel PM (1992) Childhood tuberculosis and tuberculous meningitis: high incidence rates in the Western Cape of South Africa. Tuber Lung Dis 73(6):349–355
Deeny JE, Walker MJ, Kibel MA, Molteno CD, Arens LJ (1985) Tuberculous meningitis in children in the Western Cape. Epidemiology and outcome. S Afr Med J 68(2):75–78
Farinha NJ, Razali KA, Holzel H, Morgan G, Novelli VM (2000) Tubercolosis of the central nervous system in children: a 20 year survey. J Infect 41:61–68
Andronikou S, Smith B, Hatherhill M, Douis H, Wilmshurst J (2004) Definitive neuroradiological diagnostic features of tuberculous meningitis in children. Pediatr Radiol 34:876–885
Tayfun C, Ucoz T, Tasar M, Atac K, Ogur, Ozturk T, Yinanc MA (1996) Diagnostic value of MRI in tuberculous meningitis. Eur Radiol 6:380–386
Schoeman CJ, Herbst I, Nienkemper DC (1997) The effect of tuberculous meningitis on cognitive and motor development of children. S Afr Med J 87(1):70–72
Schoeman JF, Van Zyl LE, Laubscher JA, Donald PR (1995) Serial CT scanning in childhood tuberculous meningitis: prognostic features in 198 cases. J Child Neurol 10:320–329
Kingsley DPE, Hendrickse WE, Kendall BE, Swash M, Singh V (1987) Tuberculous meningitis: role of CT in management and prognosis. J Neurol Neurosurg Psychiatry 50:30–36
Gupta RK, Gupta S, Singh D, Sharma B, Kohli A, Gujral RB (1994) MR imaging and angiography in tuberculous meningitis. Neuroradiol 36:87–92
Chang KH, Han MH, Roh JK, Kim IO, Han MC, Choi KS, Kim CW (1990) Gd-DTPA enhanced MR imaging in intracranial tuberculosis. Neurorad 32:19–25
Hooijboer PGA, Van Der Vliet AM, Sinnige LGF (1996) Tuberculous meningitis in native Dutch children: a report of four cases. Pediatr Radiol 26:542–546
Gupta RK, Jena A, Sharma A, Guha DK, Khushu S, Gupta AK (1988) MR imaging of intracranial Tuberculomas. J Comput Assist Tomogr 12:280–285
Gupta RK, Prakash M, Mishra AM, Husain M, Prasad KN, Husain N (2005) Role of diffusion weighted imaging in differentiation of intracranial tuberculoma and tuberculous abscess from cysticercus granulomas-a report of more than 100 lesions. Eur J Radiol 55:384–392
Wasay M, Kheleani BA, Moolani MK, Zaheer J, Pui M, Hasan S, Muzaffar S, Bakshi R, Sarawari AR (2003) Brain CT and MRI findings in 100 consecutive patients with intracranial tuberculoma. J Neuroimaging 13:240–247
Chan KH, Cheung RTF, Lee R, Mak W, Ho SL (2005) Cerebral infarcts complicating tuberculous meningitis. Crerbrovasc Dis 19:391–395
Rovira M, Romero F, Terrent O, Ibarra B (1980) Study of tuberculous meningitis by CT. Neuroradiol 19:137–141
Jinkins JR (1991) Computed tomography of intracranial tuberculosis. Neuroradiology 33:126–135
De Castro CC, De Barros NC, De Sousa Campos ZM, Cerri GG (1995) CT scans of intracranial tuberculosis. Radiol Clin North Am 33:753–769
Andronikou S, Wieselthaler N, Smith B, Douis H, Fieggen AG, van Toorn R, Wilmshurst J (2005) Value of early follow-up CT in paediatric tuberculous meningitis. Pediatr Radiol 35:1092–1099
Reid H, Fallen RJ (1992) Bacterial infections. In: Adams JH, Duchen L (eds) Greenfield’s Neuropathology, 5th edn. Oxford University Press, New York, p 317
Donald PR, Schaaf HS, Schoeman JF (2005) Tuberculous meningitis and military tuberculosis: the Rich focus revisited. J Infection 50:193–195
Cho IC, Chang KH, Kim YH, Kim SH, Yu IK, Han MH (1998) MRI features of choroid plexitis. Neuroradiol 40:303–307
Offenbacher H, Fazekas F, Schmidt R, Kleinert R, Payer F, Kleinert G, Lechner H (1991) MRI in tuberculous meningoencephalitis: report of four cases and review of neuroimaging literature. J Neurol 238:340–344
Norman J, Waecker JR, Conner JD (1990) Central nervous system tuberculosis in children: a review of 30 cases. Pediatr Infect Dis J 9:539–543
Ozates M, Kemaloglu S, Gurkan, Ozkan U, Hosoglu S, Simsek MM (2000) CT of the brain in tuberculous meningitis. A review of 289 patients. Acta Radiol 41:13–17
Jinkins JR, Gupta R, Chang KH, Roderigues-Carbajal J (1995) MR imaging of central nervous system tuberculosis. Radiol Clin North Am 33:771–786
Gelabert M, Castro-Gago M (1998) Hydrocephalus and tuberculous meningitis in children. Report on 26 cases. Childs Nerv Syst 4:268–270
Schoeman J, Hewlitt R, Donald P (1988) MR of childhood tuberculous meningitis. Neuroradiol 30:473–477
Burrill J, Williams CJ, Bain G, Conder G, Hine AL, Misra RR (2007) Tuberculosis: a radiological review. Radiographics 27:1255–1273
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Pienaar, M., Andronikou, S. & van Toorn, R. MRI to demonstrate diagnostic features and complications of TBM not seen with CT. Childs Nerv Syst 25, 941–947 (2009). https://doi.org/10.1007/s00381-008-0785-3
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00381-008-0785-3