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Nonfunctioning endocrine tumor arising from intracranial ectopic pancreas associated with congenital brain malformation

  • Case Report
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Abstract

Case report

We report a case of a nonfunctioning pancreatic endocrine tumor arising from intracranial ectopic pancreatic tissue.

History

An 11-year-old girl was admitted to our hospital with a brain tumor. Hydrocephalus and brain malformation were apparent at birth. We first identified a mass-like lesion in the child’s brain at age 4 months. We monitored the lesion yearly by magnetic resonance imaging (MRI) until she reached age 11 years. Gadolinium-enhanced MRI showed the lesion to be a tumor, which was resected.

Pathology

Examination of surgical specimens revealed a mature pancreatic tissue. We also identified monotonous neoplastic cells with round nuclei and positive immunoreactivity for synaptophysin, chromogranin A, and neurospecific enolase. However, these cells were negative for pancreatic endocrine markers. We diagnosed nonfunctioning pancreatic endocrine tumor arising from intracranial ectopic pancreatic tissue.

Conclusion

Migrating pancreatic elements may have induced brain malformation during embryonic development and subsequently become malignant.

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Authors and Affiliations

  1. Department of Neurosurgery, Fukuoka University Faculty of Medicine, 45-1, 7-chome, Nanakuma Jonan-ku, Fukuoka, 814-0180, Japan

    Hitoshi Tsugu, Shinya Oshiro, Hiroshi Kawaguchi & Takeo Fukushima

  2. Department of Pathology, Fukuoka University Faculty of Medicine, Fukuoka, Japan

    Kazuki Nabeshima & Shinji Matsumoto

  3. Department of Pediatrics, Fukuoka University Faculty of Medicine, Fukuoka, Japan

    Yuko Nomura & Sawa Yasumoto

  4. Department of Radiology, Fukuoka University Faculty of Medicine, Fukuoka, Japan

    Koichi Takano & Hidetsuna Utsunomiya

Authors
  1. Hitoshi Tsugu
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  2. Shinya Oshiro
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  3. Hiroshi Kawaguchi
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  4. Takeo Fukushima
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  5. Kazuki Nabeshima
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  6. Shinji Matsumoto
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  7. Yuko Nomura
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  8. Sawa Yasumoto
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  9. Koichi Takano
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  10. Hidetsuna Utsunomiya
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Corresponding author

Correspondence to Hitoshi Tsugu.

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Tsugu, H., Oshiro, S., Kawaguchi, H. et al. Nonfunctioning endocrine tumor arising from intracranial ectopic pancreas associated with congenital brain malformation. Childs Nerv Syst 23, 1337–1340 (2007). https://doi.org/10.1007/s00381-007-0391-9

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  • DOI: https://doi.org/10.1007/s00381-007-0391-9

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