Abstract
Background
Brain tumors are the second most common neoplasm in children. Pattern of primary brain tumors in children has not been reported in Iran. Brain tumors have been the subject of controversy both with respect to pattern of occurrence and to potential causes.
Objective
To determine the age, sex, location, and histologic diagnosis of intracranial tumors in children less than 15 years of age.
Materials and methods
A retrospective study of 619 children who were admitted to the neurosurgical center between 1978 and 2003 was performed. Charts were reviewed to extract information about demographics, location, and histopathological diagnosis of tumors. All patients entered into this study had pathologically proven brain tumor. The frequency distribution of brain tumors by age and sex, location, and histopathology was calculated.
Results
The male–female ratio, 58.1 to 41.9%, vary significantly (p<0.05). The mean age of the patients at time of diagnosis was 8.8 years (SD=3.9). Fifty-one percent of brain tumors were located in supratentorial, and 49.0% in the infratentorial region. In supratentorial region, 57.0% of the tumors were in the hemispheric. In infratentorial region, 68% of the tumors were in the midline. The mixed five most common histological diagnoses in patients were astrocytoma (40.4%), followed by medulloblastoma (18.4%), ependymoma (10.5%), craniopharyngioma (8.8%), and meningioma (4.2%). Most of the brain tumor types (85%) occurred in children between 5 to 15 years of age. Astrocytoma occurred mostly in children aged 5–15 years (87%).
Conclusion
Males were affected more than females. A significant male predominance was observed in craniopharyngioma and medulloblastoma. Astrocytoma was the first most common brain tumor in all age groups. Certain tumor types show a predilection for the certain period of life.
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References
Agaoglu FY, Ayan I, Dizdar Y, Kebudi R, Gorgun O, Darendeliler E (2005) Ependymal tumors in childhood. Pediatr Blood Cancer 45:298–303
Baldwin RT, Preston-Martin S (2004) Epidemiology of brain tumors in childhood—a review. Toxicol Appl Pharmacol 199:118–131
Behren JB, Reymond P (2003) Birth characteristics and brain cancers in young children. Int J Epidemiol 32:248–256
Bunin GR, Surwicz TS, Witmen PA, Preston-Martin S, Davis F (1998) The descriptive epidemiology of craniopharyngioma. J Neurosurg 89:547–551
Cho KT, Wang KC, Kim SK, Shin SH, Chi JG, Cho BK (2002) Pediatric brain tumors: statistics of SNUH, Korea (1959–2000). Childs Nerv Syst 18:30–37
Rickert CH, Paulus W (2001) Epidemiology of central nervous systems in childhood and adolescence based on the new WHO classification. Childs Nerv Syst 17:503–511
Duvin FG, McCarthy B, Jukich P (1999) The descriptive epidemiology of brain tumors. Neuroimaging Clin N Am 9:581–594
Greenwald ED, Greenwald ES (1983) Cancer epidemiology. Medical Examination Publishing, Hyde Park, NY
Hanif G, Shafqat S (2004) Morphological pattern and frequency of intracranial tumors in children. J Coll Physicians Surg Pak 14:150–152
Kaatsch P, Rickert CH, Kuhl J, Schuz J, Michaelis J (2001) Population-based epidemiologic data on brain tumors in German children. Cancer 92:3155–3164
Kadri H, Mawla AA, Murad L (2005) Incidence of childhood brain tumors in Syria (1993–2002). Childs Nerv Syst 41:173–177
Kaiser J (1999) No meeting of minds on childhood cancer. Science 286:1832–1834
Kalus JZ (1986) Epidemiology of brain tumors-general statistics and biological data, brain tumors their biology and pathology. Springer, Berlin Heidelberg New York, pp 86–103
Keene Daniel L, Hsu E, Ventureya E (1998) Brain tumors in childhood and adolescence. Pediatr Neurol 20:198–203
Lang O, Kondas O, Torok S, Hauser P, Bognar L, Schuler D (2002) Incidence of pediatric brain tumors in Hungry between 1989–1999. Orv Hetil 143:451–454
Lannering B, Marky I, Nordborg C (1990) Brain tumors in childhood and adolescence in West Sweden 1970–1984. Epidemiology and survival. Cancer 66:604–609
National Cancer Report (2003) Ministry of health and medical education, Islamic Republic of Iran, Tehran, Iran
Preston-Martin S, Staples M, Ferrugi H, Giles G (1993) Primary tumors of the brain, cranial nerves and cranial meninges in Victoria, Australia, 1982–1990: patterns of incidence and survival. Neuroepidemiology 12:270–279
Sardina S, Marcos R (1999) Tumors of the posterior fossa in children. Rev Neurol 28:1153–1158
Statistical Center of Iran (2002) Country’s statistics yearbook 2000–2001
Souhami R (2002) Oxford textbook of oncology. Oxford University Press. http://www.cancerbacuo.org.uk
Acknowledgement
The authors are grateful for the medical record staff at the hospital. Special thanks are due to Mr. Amin Pourhoseingholi for his help in data analysis.
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Mehrazin, M., Yavari, P. Morphological pattern and frequency of intracranial tumors in children. Childs Nerv Syst 23, 157–162 (2007). https://doi.org/10.1007/s00381-006-0198-0
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DOI: https://doi.org/10.1007/s00381-006-0198-0