Skip to main content
SpringerLink
Log in

Leptomeninges as a site of relapse in locally controlled, diffuse pontine glioma with review of literature

  • Case Report
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

Case report

Leptomeningeal involvement in diffuse intrinsic brain stem gliomas is rarely diagnosed clinically and in majority of the instances diagnosed only on postmortem examination. We report two cases of diffuse pontine glioma diagnosed clinicoradiologically and treated with conventional radiotherapy.

Observations

On follow-up, both patients showed clinical features suggestive of meningeal spread although imaging for pontine tumor showed stable disease. Leptomeningeal disease in the spine was confirmed on imaging and in one case by cerebrospinal fluid examination also. During the follow-up of patients with pontine glioma, the possibility of leptomeningeal involvement must be borne in mind.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Epstein F (1985) A staging system for brainstem gliomas. Cancer 56 (Suppl 7):1804–1806

    Article  PubMed  CAS  Google Scholar 

  2. Packer RJ, Allen J, Nielsen S et al (1983) Brainstem glioma: clinical manifestations of meningeal gliomatosis. Ann Neurol 4:177–182

    Article  Google Scholar 

  3. Halperin EC (1985) Pediatric brain stem tumors: patterns of treatment failure and their implications for radiotherapy. Int J Radiat Oncol Biol Phys 11:1293–1298

    PubMed  CAS  Google Scholar 

  4. Montravadi R, Phatak R, Bellur S et al (1982) Brain stems gliomas: an autopsy study of 25 cases. Cancer 49:1294–1296

    Article  Google Scholar 

  5. Littman P, Jarret P, Bilaniuk LT et al (1980) Pediatric brainstem gliomas. Cancer 45:2787–2792

    Article  PubMed  CAS  Google Scholar 

  6. Yoshimura J, Onda K, Tanuka R et al (2003) Clinicopathological study of diffuse type brainstem glioma: analysis of 40 cases. Neurol Med Chir (Tokyo) 43:375–382

    Article  Google Scholar 

  7. Donahue B, Allen J, Siffert J (1998) Patterns of recurrence in brain stem gliomas: evidence for craniospinal dissemination. Int J Radiat Oncol Biol Phys 40(3):677–680

    Article  PubMed  CAS  Google Scholar 

  8. Kanai R, Tasaka M, Sejima H et al (2005) Brain stem glioblastoma with multiple large cyst formation and leptomeningeal dissemination in a 4-year-old girl. Brain Dev 27(1):58–61

    Article  PubMed  Google Scholar 

  9. Tarnaris A, Edwards RJ, Lowis SP, Pople IK (2005) Atypical external hydrocephalus with visual failure due to occult leptomeningeal dissemination of a pontine glioma. J Neurosurg 102(Suppl 2):224–227

    PubMed  Google Scholar 

  10. Zagzag D, Miller DC, Knopp P et al (2000) Primitive neuroectodermal tumours of brainstem: a study of seven cases. Pediatrics 106(5):1045–1053

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiation Oncology, 116, Tata Memorial Hospital, Parel, Mumbai, 400-012, India

    Suruchi Singh, Ritu Bhutani & Rakesh Jalali

Authors
  1. Suruchi Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ritu Bhutani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rakesh Jalali
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rakesh Jalali.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Singh, S., Bhutani, R. & Jalali, R. Leptomeninges as a site of relapse in locally controlled, diffuse pontine glioma with review of literature. Childs Nerv Syst 23, 117–121 (2007). https://doi.org/10.1007/s00381-006-0168-6

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00381-006-0168-6

Keywords

Search

Navigation