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Cognitive assessment in epilepsy surgery of children

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Abstract

Introduction

Although the neurocognitive assessment in children as in the adults is an important step before and after surgery, in the literature, the data about pre- and postoperative neurocognitive evaluations in children are very few.

Objective

The purpose of this paper is to consider some peculiar aspects of the neurocognitive assessment during development, and report literature data about neuropsychological outcome of epileptic children treated with focal resection and hemispherectomy.

Results and discussion

The second section concerns our personal experience about a cohort of 45 children with refractory epilepsy operated on before 7 years. The results suggest that early surgical treatment is generally effective for seizure control and behavior improvement in children with refractory epilepsy. Concerning cognitive outcome, we found that the neurocognitive level was unchanged in the majority of the patients.

Conclusion

We underline the importance of multicentric studies with standardized neuropsychological assessments in large series of young children.

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References

  1. Achenbach TM, Edelbrock CS (1983) Manual for child behavior checklist. Department of Psychiatry, University of Vermont, Prospect Street Burlington, VT

  2. Adams CB (1983) Hemispherectomy—a modification. J Neurol Neurosurg Psychiatry 46(7):617–619

    PubMed  CAS  Google Scholar 

  3. Adams CB, Beardsworth ED, Oxbury SM, Oxbury JM, Fenwick PBC (1990) Temporal lobectomy in 44 children: outcome and neuropsychological follow-up. J Epilepsy 3:157–168 (Suppl)

    Google Scholar 

  4. Akshoomoff N, Feroleto C, Doyle E (2002) The impact of early unilateral brain injury on perceptual organization and visual memory. Neuropsychologia 40:539–561

    PubMed  Google Scholar 

  5. Andermann F (1992) Clinical indications for hemispherectomy and callosotomy. Epilepsy Res Suppl 5:189–199

    PubMed  CAS  Google Scholar 

  6. Arzimanoglou A, Aldenkamp A, Cross H, Lassonde M, Moshé S, Shmitz B (2005) Cognitive dysfunction in children with temporal lobe epilepsy. John Libbey Eurotext, Paris

    Google Scholar 

  7. Asarnow RF, LoPresti C, Guthrie D, Elliott T, Cynn V, Shields WD, Shewmon DA, Sankar R, Peacock WJ (1997) Developmental outcomes in children receiving resection surgery for medically intractable infantile spasms. Dev Med Child Neurol 39:430–440

    Article  PubMed  CAS  Google Scholar 

  8. Atkinson J (2000) The developing visual brain. Oxford University Press, Oxford

    Google Scholar 

  9. Baddeley A (1986) Working memory. Oxford University Press, Oxford

    Google Scholar 

  10. Bahn MM, Lin W, Silbergeld DL, Miller JW, Kuppusamy K, Cook RJ, Hammer G, Wetzel R (1997) Localization of language cortices by functional MR imaging compared with intracarotid Amobarbital hemispheric sedation. Am J Roentgenol 169:575–579

    CAS  Google Scholar 

  11. Bayard S, Lassonde M (2001) Cognitive, sensory and motor adjustment to hemispherectomy. In: Jambaquè I, Lassonde M, Dulac O (eds) Neuropsychology of children epilepsy. Plenum Publishers, New York

    Google Scholar 

  12. Battaglia D, Di Rocco C, Iuvone L, Carosella, D, Lettori D, Guzzetta F (1999) Neuro-cognitive development and epilepsy outcome in children with surgically treated hemimegalencephaly. Neuropediatrics 30(6):307–313

    PubMed  CAS  Google Scholar 

  13. Beardsworth ED, Adams CB (1988) Modified hemispherectomy for epilepsy: early results in 10 cases. Br J Neurosurg 2:73–84

    PubMed  CAS  Google Scholar 

  14. Beardsworth ED, Zaidel DW (1994) Memory for faces in epileptic children before and after brain surgery. J Clin Exp Neuropsychol 16:590–596

    Google Scholar 

  15. Bigel MG, Smith ML (2001) The impact of different neuropathologies on pre- and post-surgical neuropsychological functioning in children with temporal lobe epilepsy. Brain Cogn 46(1–2):46–49

    PubMed  CAS  Google Scholar 

  16. Bjorklund DF (1989) Children’s thinking: developmental function and individual differences. Brooks/Cole, Pacific Grove, CA, USA

    Google Scholar 

  17. Bjornaes H, Stabell K, Henriksen O (2001) The effects of refractory epilepsy on intellectual functioning in children and adults: a longitudinal study. Seizure 10:250–259

    PubMed  CAS  Google Scholar 

  18. Borchgrevik HM (1989) Cerebral processes underlying neuropsychological and neuromotor impairment in children with ADD/MBD. In: Sagvolden T, Archer T (eds) Attention deficit disorder. Clinical and basic research. Lawrence Eribaum Associated Ltd., Hove, UK pp 105–130

    Google Scholar 

  19. Chiricozzi F, Chieffo D, Battaglia D, Iuvone L, Acquafondata C, Cesarini L, Sacco A, Chiera R, Di Rocco C, Guzzetta F (2005) Developmental plasticity after right hemispherectomy in an epileptic adolescent with early brain injury. Childs Nerv Syst 21(11):960–969

    PubMed  CAS  Google Scholar 

  20. Chugani HT, Phelps ME, Mazzotta JC (1987) Positron emission tomography study of human brain functional development. Ann Neurol 22:287–297

    Google Scholar 

  21. Cioni G, Fazzi B, Ipata AE, Canapacchi R, van Hof-van Duin J (1996) Correlation between cerebral visual impairment and magnetic resonance imaging in children with neonatal encephalopathy. Dev Med Child Neurol 38(2):120–132

    Article  PubMed  CAS  Google Scholar 

  22. Cross JH (2002) Epilepsy surgery in childhood. Epilepsia 43(Suppl 3):65–70

    PubMed  Google Scholar 

  23. Day Spencer P, Ulatowska HK (1979) Perceptual, cognitive and linguistic development after early hemispherectomy: two case studies. Brain Lang 7:17–33

    Google Scholar 

  24. Dennis M, Whitaker HA (1976) Language acquisition following hemidecortication: linguistic superiority of the left over the right hemisphere. Brain Lang 3(3):404–433

    PubMed  CAS  Google Scholar 

  25. Deonna T, Roulet-Perez E (2005) Cognitive and behavioral disorders of epileptic origin in children. Mac Keith Press, University Children’s Hospital, Lausanne, Switzerland

    Google Scholar 

  26. Devlin AM, Cross JH, Harkness W, Chong WK, Harding B, Vargha-Khadem F, Neville BG (2003) Clinical outcomes of hemispherectomy for epilepsy in childhood and adolescence. Brain 126(Pt 3):556–566

    PubMed  CAS  Google Scholar 

  27. Diamond A, Goldman -Rakic P (1985) Evidence for involvement of prefrontal cortex in cognitive changes during the first year of life: comparison of human infants and rhesus monkeys on a detour task with transparent barrier. Neuroscience 11:832

    Google Scholar 

  28. Dlugos DJ, Moss EM, Duhaime AC, Brooks-Kayal AR (1999) Language-related cognitive declines after left temporal lobectomy in children. Pediatr Neurol 21(1):444–449

    PubMed  CAS  Google Scholar 

  29. Duchowny M, Jayakar P, Resnick T, Harvey AS, Alvarez L, Dean P, Gilman J, Yaylali I, Morrison G, Prats A, Altman N, Birchansky S, Bruce J (1998) Epilepsy surgery in the first three years of life. Epilepsia 39(7):737–743

    PubMed  CAS  Google Scholar 

  30. Elger CE, Lendt M, Helmestaedert C, Kowalik A (1998) Pre- and postoperative neuropsychological assessment of children with pharmaco-resistant epilepsies. In: Bureau M, Kahane P, Munari (eds) Epilepsies partielles graves pharmaco-resistantes de enfant: strategies diagnostiques chirurgicaux. John Libbey, Mount Rouge, France

    Google Scholar 

  31. Elger CE, Brckachaus A, Lendt M, Kowalik A and Steidele (1997) Behaviour and cognition in children with temporal lobe epilepsy. In: Tuxorn I, Holthausen H, Boenigk H (eds) Paediatric epilepsy syndromes and surgical treatment. John Libbey, London

    Google Scholar 

  32. Fagan J (1973) Infant delayed recognition memory forgetting. J Exp Child Psych 16:424–450

    Google Scholar 

  33. Flechter JM, Taylor HG (1984) Neuropsychological approaches to children: towards a developmental neuropsychology. J Clin Neuropsychol 6:39–56

    Google Scholar 

  34. Freitag H, Tuxhorn I (2005) Cognitive function in preschool children after epilepsy surgery: rationale for early intervention. Epilepsia 46(4):561–567

    PubMed  Google Scholar 

  35. Gilliam F (1997) Epilepsy surgery outcome: comprehensive assessment in children. Neurology 48:1368–1374

    PubMed  CAS  Google Scholar 

  36. Gleissner U, Sassen R, Lendt M, Clusmann H, Elger CE, Helmstaedter C (2002) Pre and post operative verbal memory in paediatric patients with temporal lobe epilepsy. Epilepsy 51:287–296

    CAS  Google Scholar 

  37. Gleissner U, Sassen R, Schramm J, Elger CE, Helmstaedter C (2005) Greater functional recovery after temporal lobe epilepsy surgery in children. Brain 128(Pt 12):2822–2829. (Epub Jul 13)

    PubMed  CAS  Google Scholar 

  38. Gomes H, Molholm S, Christodoulou C, Ritter W, Cowan N (2000) The development of auditory attention in children. Front Biosci 5:108–120

    Google Scholar 

  39. Grattan LM, Eslinger (1991) Frontal lobe damage in children and adults: a comparative review. Dev Neuropsychol 7:283–326

    Google Scholar 

  40. Griffiths R (1996) The griffiths mental development scales from birth to 2 years. Manual. The Test Agency Limited, Henley-on-Thames, London

    Google Scholar 

  41. Guzzetta F, Frisone MF, Ricci D, Rando T, Guzzetta A (2002) Development of visual attention in West syndrome. Epilepsia 43(7):757–763

    PubMed  Google Scholar 

  42. Helmstaedter C, Lendt M (2001) Neuropsychological outcome of temporal and extratemporal lobe resection in children. In: Jambaque I, Lassond M, Dulac O (eds) Neuropsychology of childhood epilepsy. Kluwer Academic Plenum Publishers, New York

    Google Scholar 

  43. Harvey AS, Anderson D, Jackson G (1999) Functional MRI of expressive language in children with partial epilepsy and left hemisphere lesions. Epilepsia 40:183

    Google Scholar 

  44. Helmstaedter C, Kemper B, Elger CE (1996) Neuropsychological aspects of frontal lobe epilepsy. Neuropsychologia 34:399–406

    PubMed  CAS  Google Scholar 

  45. Holmes GB, Bernstein J, Prather PA, Rey-Casserly C (1995) Neuropsychological assessment in preoperative and postoperative evaluation. Neurosurg Clin N Am 6:443–454

    Google Scholar 

  46. Humbertclaude VT, Coubes PA, Robain O, Echenne BB (1997) Early hemispherectomy in a case of hemimegalencephaly. Pediatr Neurosurg 27:268–271

    Article  PubMed  CAS  Google Scholar 

  47. Irle E (1987) Lesion size and recovery of function: some new perspectives. Brain Res Rev 12:307–320

    Google Scholar 

  48. Jambaqué I, Lassonde M, Dulac O (2001) Neuropsychology of childhood epilepsy. Kluwer Academic Plenum Publishers, New York

    Google Scholar 

  49. Jonas R, Nguyen S, Hu B, Asarnow RF, LoPresti C, Curtiss S, de Bode S, Yudovin S, Shields WD, Vinters HV, Mathern GW (2004) Cerebral hemispherectomy: hospital course, seizure, developmental, language, and motor outcomes. Neurology 62(10):1712–1721

    PubMed  CAS  Google Scholar 

  50. Jones-Gotman M, Smith ML, Zatorre RJ (1993) Neuropsychological testing for localizing and lateralizing the epileptic region. In: Engel J Jr (ed) Surgical treatment of the epilepsies. Rave, New York, pp 245–261

    Google Scholar 

  51. Kennard MA (1938) Reorganization of motor function in the cerebral cortex of monkeys deprived of motor and premotor areas in infancy. J Neurophysiol 1:477–496

    Google Scholar 

  52. Kohn B, Dennis M (1974) Selective impairments of visuo-spatial abilities in infantile hemiplegics after right cerebral hemidecortication. Neuropsychologia 12:505–512

    PubMed  CAS  Google Scholar 

  53. Klein B, Bonnie E, Duchowny M, Liabre M (2000) Cognitive outcome of children with epilepsy and malformations of cortical development. Neurology 55:230–235

    PubMed  CAS  Google Scholar 

  54. Kolb B, Whishaw IQ (1990) Fundamentals of human neuropsychology, 3rd edn. Freeman, New York

    Google Scholar 

  55. Kuhen SM, Keene DL, Richards PMP, Ventureyra ECG (2002) Are the changes in intelligence and memory functioning following surgery for the treatment of refractory epilepsy in childhood? Child’s Nerv Syst 18:306–318

    Google Scholar 

  56. Labate A, Briellmann R, Waites AB, Harvey AS, Jackson G (2004) Temporal lobe developmental tumors: an fMRI study for language lateralization. Epilepsia 41:1456–1462

    Google Scholar 

  57. Lah S (2004) Neuropsychological outcome following focal cortical for intractable epilepsy in children. Epilepsy Behav 5:804–817

    PubMed  Google Scholar 

  58. Lanzi G, Fazzi E, Uggetti C, Cavallini A, Da Nova S, Egitto MG, Ginevra OF, Salati R, Bianchi PE (1998) Cerebral visual impairment in periventricular leukomalacia. Neuropediatrics 29(3):145–150

    PubMed  CAS  Google Scholar 

  59. Lassonde M, Sauerwein HC, Jambaqué I (2000) Neuropsychology of childhood epilepsy: pre- and postsurgical assessment. Epileptic Disord 2:3–13

    PubMed  CAS  Google Scholar 

  60. Lendt M, Gleissner U, Helmstaedter C, Sassen R, Clusmann H, Elger CE (2002) Neuropsychological outcome in children after frontal lobe epilepsy surgery Epilepsy Behav 3(1):51–59

    PubMed  Google Scholar 

  61. Lendt M, Helmstaedter C, Elger CE (1999) Pre- and post-operative neuropsychological profiles in children and adolescents with temporal lobe epilepsy. Epilepsia 40:1543–1550

    PubMed  CAS  Google Scholar 

  62. Lennenberg EH (1967) Biological foundation of language. Wiley, New York

    Google Scholar 

  63. Liegeois F, Connelly A, Salmond CH, Gadian DG, Vargha-Khadem F, Baldeweg T (2002) A direct test for lateralization of language activation using fMRI: comparison with invasive assessment in children with epilepsy. Neuroimage 17:1861–1867

    PubMed  CAS  Google Scholar 

  64. Lindsay J, Ounsted C, Richards P (1987) Hemispherectomy for childhood epilepsy: a 36-year study. Dev Med Child Neurol 29:592–600

    Article  PubMed  CAS  Google Scholar 

  65. Luerding R, Boesebeck F, Ebner A (2004) Cognitive changes after epilepsy surgery in the posterior cortex. J Neurol Neurosurg Psychiat 75(49):583–587

    PubMed  CAS  Google Scholar 

  66. Luria AR (1973) The working brain. Basic Books, New York

    Google Scholar 

  67. Mabbott MD, Smith ML (2003) Material specific memory in children with temporal and extratemporal lobectomy. Neuropsychologia 41:995–1007

    PubMed  Google Scholar 

  68. Martinez A (1997) Hemispheric asymmetries in global and local processing: evidence from fMRI. Neuroreport 8:1685–1689

    PubMed  CAS  Google Scholar 

  69. Mc Carthy RA, Warrington EK (1990) Cognitive neuropsychology: a clinical introduction. Academic, New York

    Google Scholar 

  70. Mc Fie J (1961) The effects of hemispherectomy on intellectual functioning in cases of infantile hemiplegia. J Neurol Neurosurg Psychiatry 24:240–249

    Article  Google Scholar 

  71. Mc Kay KE, Halperin JM, Schwartz ST (1994) Developmental analysis of three aspects of information processing: sustained attention, selective attention, and response organization. Dev Neuropsychol 10:121–132

    Article  Google Scholar 

  72. Mercuri E, Haataja L, Guzzetta A, Anker S, Cowan F, Rutherford M, Andrew R, Braddick O, Cioni G, Dubowitz L, Atkinson J (1999) Visual function in term infants with hypoxic insults: correlation with neurodevelopmental at 2 years of age. Arch Dis Child Fetal Neonatal Ed 80:F99–F104

    PubMed  CAS  Google Scholar 

  73. Meyer FB, Marsh WR, Lawa ER, Sharbrough FW (1986) Temporal lobectomy in children. J Neurosurg 64:371–376

    PubMed  CAS  Google Scholar 

  74. Miranda C, Smith ML (2001) Predictors of intelligence after temporal lobectomy in children with epilepsy. Epilepsy Behav 2:1–8

    Google Scholar 

  75. Muter V, Taylor S, Vargha-Khadem F (1997) A longitudinal study of early intellectual development in hemiplegic children. Neuropsychologia 35(3):289–298

    PubMed  CAS  Google Scholar 

  76. Nolan MA, Redoblado MA, Lah S, Sabaz M, Lawson JA, Cunningham AM, Bleasel AF, Bye AM (2003) Intelligence in childhood epilepsy syndromes. Epilepsy Res 53:139–150

    PubMed  Google Scholar 

  77. Ogunmenkan AO, Hwang PA, Hoffmann HJ (1989) Sturge–Weber–Dimitri disease: role of hemispherectomy in prognosis. Can J Neurol Sci 16(1):78–80

    Google Scholar 

  78. OguniI H, Mukahira K, Tanaka T, Awaya Y, Saito K, Shimizu H, Oda M, Araj N, Suzuki I, Osawa M (2000) Symposium I: surgical indication for refractory childhood epilepsy. Epilepsia 41(Suppl 9):S21–S25

    Google Scholar 

  79. Oxbury S (1997) Neuropsychological evaluation-children. In: Engel J Jr, Pedley TA (eds) Epilepsy: a comprehensive textbook. Lippincott-Raven Publishers, Philadelphia, pp 989–999

    Google Scholar 

  80. Peacock WJ, Wehby-Grant MC, Shield WD, Sherwmon DA, Chugani HT, Sankar R, Vinters HV (1996) Hemispherectomy for intractable seizures in children: a report of 58 cases. Child’s Nerv Syst 12:376–384

    CAS  Google Scholar 

  81. Peacock WJ (1995) Hemispherectomy for the treatment of intractable seizures in childhood. Neurosurg Clin N Am 6(3):549–563

    PubMed  CAS  Google Scholar 

  82. Poirier P, Lassonde M, Villemure JG, Geoffroy G, Lepore F (1994) Sound localization in hemispherectomized patients. Neuropsychologia 32(5):541–553

    PubMed  CAS  Google Scholar 

  83. Posner M, Peterson SE (1990) The attention system of human brain. Annu Rev Neurosci 15:25–42

    Google Scholar 

  84. Ptito M, Tassinari G, Antonini A (1987) Electrophysiological evidence for interhemispheric connections in the anterior ectosylvian sulcus in the cat. Exp Brain Res 66(1):90–98

    PubMed  CAS  Google Scholar 

  85. Pulsifer MB, Brandt J, Salorio CF, Vining EP, Carson BS, Freeman JM (2004) The cognition outcome of hemispherectomy in 71 children. Epilepsia 45(3):243–254

    PubMed  Google Scholar 

  86. Rebolledo FA, Garcia CR, Mares DR, Rojas JC (2002) Sindrome de Rasmussen. Seguimento de siete anos. Aspectos relacionades con plasticidad cerebral en epilepsia. Rev Invest Clin 54(3):209–217

    Google Scholar 

  87. Riva D, Cazzaniga L, Pantaleoni C, Pecchini M (1986) Development of hemisphere specialization for spatial skills in children from six to twelve years of age. Ital J Neurol Sci 2(Suppl 5):155–168

    Google Scholar 

  88. Riva D, Nichelli F, Devoti M (2000) Developmental aspects of verbal fluency and confrontation naming in children. Brain Lang 71:267–284

    PubMed  CAS  Google Scholar 

  89. Robinson S, Park TS, Blackburn LB, Bourgeois BF, Arnold ST, Dobson WE (2000) Transparahippocampal selective amygdalahippocampectomy in children and adolescents: efficacy procedure and cognitive morbidity in patients. J Neurosurg 93:402–409

    PubMed  CAS  Google Scholar 

  90. Siegler RS (1991) Children’s thinking. Prentice-hall, Englewood Cliffs, NJ

    Google Scholar 

  91. Siegel AM, Williamson PD (2000) Parietal lobe epilepsy. Adv Neurol 84:189–199

    PubMed  CAS  Google Scholar 

  92. Sinclair DB, Aronyk K, Snyder T, McKean JDS, Wheatley M, Bastos A, Hao C, Colmers W (2004) Extratemporal resection for childhood epilepsy. Pediatr Neurol 30:177–185

    PubMed  Google Scholar 

  93. Smith A (1977) Language and non language functions after right or left hemispherectomy for cerebral lesions in infancy. Presented at the 5th Annual Meeting of the International Neuropsycological Society, February 3, Santa Fe, New Mexico

  94. Smith ML, Elliott IM, Lach L (2004) Cognitive, psychosocial, and family function one year after pediatric epilepsy surgery. Epilepsia 45(6):650–660

    PubMed  Google Scholar 

  95. Stiles J, Stern C, Turner D (1996) Developmental change in spatial grouping activity among children with early focal brain injury: evidence from a modeling task. Brain Cogn 31:46–62

    PubMed  CAS  Google Scholar 

  96. Sugimoto T, Otsubo H, Hwang PA, Hoffman HJ, Jay V, Snead OC 3rd (1999) Outcome of epilepsy surgery in the first three years of life. Epilepsia 40(5):560–565

    PubMed  CAS  Google Scholar 

  97. Szabo CA, Wyllie E, Stanford LD, Geckler C, Kotagal P, Comair YG, Thornton AE (1998) Neuropsychological effect of temporal lobe resection in preadolescent children with epilepsy. Epilepsia 39:814–819

    PubMed  CAS  Google Scholar 

  98. Trenerry MR, Loring DW, Petersen RC (1996) The Wada Test. In: Wyllie E (ed) The treatment of epilepsy: principles and practice, 2nd edn. Williams & Wilkins, Baltimore, MD, pp 1000–1005

    Google Scholar 

  99. Vargha-Khadem F, Polkey CE (1992) A Review of cognitive outcome after hemidecortication in humans. In: FD Rose, Johnson DA (eds) Recovery from brain damage: advances in experimental medicine and biology 35. Reflections and directions. Plenum, New York, pp 137–151

    Google Scholar 

  100. Vargha-Khadem F, Carr LJ, Isaacs E, Brett E, Adams C, Mishkin M (1997) Onset of speech after left hemispherectomy in a nine year old boy. Brain 120:159–182

    PubMed  Google Scholar 

  101. Vargha-Khadem F (2001) Generalized versus selective cognitive impairments resulting from brain damage sustained in childhood. Epilepsia 42(Suppl 1):37–40

    PubMed  Google Scholar 

  102. Vargha-Khadem F, Isaacs E, Muter V (1994) A review of cognitive outcome after unilateral lesions sustained during childhood. J Child Neurol 9(Suppl 2):2S67–2S73

    Article  Google Scholar 

  103. Verity CM, Strauss EH, Moyes PD, Wada JA, Dunn HG, Lapointe JS (1982) Long-term follow-up after cerebral hemispherectomy: neurophysiologic, radiologic, and psychological findings. Neurology 32(6):629–639

    PubMed  CAS  Google Scholar 

  104. Vining EPG, Freeman JM, Pillas DJ, Uematsu S, Carson BS, Brandt J, Boatman D, Pulsifer MB, Zuckerberg A (1997) Why would you remove half a brain? The outcome of 58 children after hemispherectomy—the John Hopkins experience: 1968–1996. Pediatrics 100:163–171

    PubMed  CAS  Google Scholar 

  105. Weber DA, Berl MM, Moore EN, Gioia GA, Riltz EK, Ratner NB, Vaidya C, Gaillard WD (2005) Temporal lobe epilepsy and cognition in children: will fMRI be of some help for a better understanding of the mechanisms involved? In: Arzimanoglou et al. (eds) Cognitive dysfunction in children with temporal lobe epilepsy. John Libbey Eurotext, Mont Rouge: France

    Google Scholar 

  106. Wechsler D (1992) WIPPSI—Scala di Intelligenza Wechsler per Fanciulli Riveduta—O.S. Organizzazioni Speciali. Firenze

  107. Wechsler D (1998) WISC-R—Scala di Intelligenza Wechsler per Bambini Riveduta—Manuale—O.S. Organizzazioni Speciali. Firenze

  108. Westerveld M, Sass KJ, Chelune GJ, Hermann BP, Barr WB, Loring DW, Strauss E, Trenerry MR, Perrine K, Spencer DD (2000) Temporal lobectomy in children: cognitive outcome. J Neurosurg 92(1):24–30

    Article  PubMed  CAS  Google Scholar 

  109. Williams J, Griebel ML, Sharp GB, Boop FA (1998) Cognition and behavior after temporal lobectomy in pediatric patients with intractable epilepsy. Pediatr Neurol 19(3):189–194

    PubMed  CAS  Google Scholar 

  110. Woermann FG, Jokeit H, Luerding R, Freitag H, Schutz R, Guertler S et al (2003) Language lateralization by Wada test and fMRI. Neurology 61(5):699–701

    PubMed  CAS  Google Scholar 

  111. Wyllie E (1996) Surgery for catastrophic localization-related epilepsy in infants. Epilepsia 37(Suppl 1):S22–S25

    PubMed  Google Scholar 

  112. Wyllie E, Comair YG, Kotagal P, Bulacio J, Bingaman W, Ruggieri P (1998) Seizure outcome after epilepsy surgery in children and adolescents. Ann Neurol 44(5):740–748

    PubMed  CAS  Google Scholar 

  113. Wyllie E (2000) Surgical Treatment of epilepsy in Pediatric Patients. Can J Neurol Sci 27(2):106–110

    PubMed  CAS  Google Scholar 

  114. Yuan W, Szaflarski JP, Schmithorst VJ, Schapiro M, Byars AW, Strawsburg RH, Holland SK (2006) fMRI shows atypical language lateralization in pediatric epilepsy patients. Epilepsia 47(3):593–600

    PubMed  Google Scholar 

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Battaglia, D., Chieffo, D., Lettori, D. et al. Cognitive assessment in epilepsy surgery of children. Childs Nerv Syst 22, 744–759 (2006). https://doi.org/10.1007/s00381-006-0151-2

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