Abstract
Objects
The aims of the study were (1) to review the pathological findings of spinal lipomatous masses associated with congenital spinal dysraphism and (2) to discuss the pathological diagnosis.
Methods
The pathological records of 47 patients at our institution were reviewed, and three illustrative cases were presented.
Conclusion
Spinal tumorous lesions associated with spinal dysraphism have been traditionally described as lipoma since they are composed mostly of fatty tissue. However, they are different from lipomas arising in other part of the body in that they often contain various tissues of ecto- and mesodermal origin. In our study, we detected such heterotopic components in 24 out of 47 cases. Although they are also similar to teratoma, it is generally accepted that they are malformative lesions which lack neoplastic potential. We therefore should diagnose them as hamartoma rather than lipoma or teratoma.
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References
Muraszko K, Youkilis A (2000) Intramedullary spinal tumors of disordered embryogenesis. J Neurooncol 47:271–281
Pierre-Kahn A, Zerah M, Renier D, Cinalli G, Sainte-Rose C, Lellouch-Tubiana A, Brunelle F, Merrer ML, Giudicelli Y, Pichon J, Kleinknecht B, Nataf F (1997) Congenital lumbosacral lipomas. Childs Nerv Syst 13:298–335
Lellouch-Tubiana A, Zerah M, Catala M, Brousse N, Kahn AP (1999) Congenital intraspinal lipomas: histological analysis of 234 cases and reviews of the literature. Pediatr Dev Pathol 2:346–352
Khanna G, Mishra K, Agarwal S, Sharma S (1999) Congenital spinal lipomas-tumor versus hamartoma. Indian J Pediatr 66:940–944
Walsh JW, Markesbery WR (1980) Histological features of congenital lipomas of the lower spinal canal. J Neurosurg 52:564–569
Morris GF, Murphy K, Rorke LB, James HE (1998) Spinal hamartomas: a distinct clinical entity. J Neurosurg 88:954–951
Castillo M, Smith MM, Armao D (1999) Midline spinal cord hamartomas: MR imaging features of two patients. AJNR 20:1169–1171
Bouton JM, Martin CH, Rickham PP (1966) Hamartoma and spina bifida. J Pediatr Surg 1:559–565
Molleston MC, Roth KA, Wippold FJ, Grubb RL (1991) Tethered cord syndrome from a choristoma of mullerian origin. J Neurosurg 74:497–500
Rougier A, Vital C, Caillaud P (1993) Uterus-like mass of the conus medullaris with associated tethered cord. Neurosurgery 33:328–331
Koen JL, Mclendon RE, George TM (1998) Intradural spinal teratoma: evidence for a dysembryogenic origin. J Neurosurg 89:844–851
Hamada H, Kurimoto H, Hayashi N, Hirashima Y, Matsumura N, Endo S (2001) Intramedullary spinal teratoma with spina bifida. Childs Nerv Syst 17:109–111
Al-Sarraj ST, Parmar D, Dean AF, Phookun G, Bridges LR (1998) Clinicopathological study of seven cases of spinal cord teratoma: a possible germ cell origin. Histopathology 32:51–56
Hillman J, Bynke O (1992) Description of two informative cases of occult spinal dysraphism with remarks on possible traits in the embryogenesis. Childs Nerv Syst 8:211–214
Li YC, Shin SH, Cho BK, Lee MS, Lee YJ, Hong SK, Wang KC (2001) Pathogenesis of lumbosacral lipoma: a test of the ‘Premature dysjunction’ theory. Pediatr Neurosurg 34:124–130
Catala M (1997) Embryogenesis. Why do we need a new explanation for the emergence of spina bifida with lipoma? Childs Nerv Syst 13:336–340
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Takeyama, J., Hayashi, T., Saito, M. et al. Spinal hamartoma associated with spinal dysraphism. Childs Nerv Syst 22, 1098–1102 (2006). https://doi.org/10.1007/s00381-005-0016-0
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DOI: https://doi.org/10.1007/s00381-005-0016-0