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Assessment of visit-to-visit variability in systolic blood pressure over 5 years and phasic left atrial function by two-dimensional speckle-tracking echocardiography

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Abstract

Visit-to-visit variability in systolic blood pressure (VVV-SBP) has been associated with increased cardiac events. Hence, volume analysis by two-dimensional speckle-tracking echocardiography (2-DSTE) allows physicians to easily measure phasic left atrial (LA) function. However, the relationship of VVV-SBP and functional deformation of the left atrium with patients’ clinical outcome is unclear. The aim of the study was to investigate the relationship between phasic LA function and VVV-SBP. The subjects were 70 male participants in whom 2-DSTE was performed to measure blood pressure at health check-ups every year for 5 years. The standard deviation of systolic blood pressure (SBP) was calculated to assess VVV-SBP. The average SBP (Ave-SBP) was also assessed. Total emptying function (EF) (reservoir function), passive EF (conduit function), and active EF (booster pump function) of the left atrium were calculated to evaluate phasic LA function by 2-DSTE. The Pearson correlation, simple regression analysis, and multivariate logistic regression analysis were used in data analysis. Participants’ mean age was 50 ± 10 years, and 16 participants had hypertension. VVV-SBP correlated with total EF (r =  – 0.30, p = 0.014) and active EF (r =  – 0.35, p = 0.003). There was no correlation between the standard deviation of SBP and passive EF (r =  – 0.10, p = 0.39). Ave-SBP had no significant relationship with total EF (r =  – 0.06, p = 0.62), passive EF (r =  – 0.08, p = 0.50), or active EF (r =  – 0.03, p = 0.78). Active EF was also associated with VVV-SBP in multiple regression analysis. The active EF was significantly decreased in the highest quartile of VVV-SBP. Despite the small sample size of our study, the VVV-SBP showed a relationship with the phasic LA function. Our findings suggest that high VVV-SBP is noted to be associated with cardiovascular risk including a deterioration of LA function in clinical practice.

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Acknowledgements

We gratefully appreciated to Ms. Nakanishi T and Ms. Nakamura M for supporting of data acquire and preparation of manuscripts. We also would like to thank Mr. Sato N and Ms. Nagaya M for supporting experimental equipment.

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Authors and Affiliations

  1. The Department of Cardiology, Asahi University Hospital, 3-23 Hashimoto-cho, Gifu, 500-8523, Japan

    Shinichiro Tanaka, Tomonori Segawa, Natsumi Tsugita, Takahiro Fuseya & Tomonori Kawaguchi

  2. Gifu Prefectural General Medical Center, Gifu, Japan

    Toshiyuki Noda, Makoto Iwama & Sachiro Watanabe

  3. Minagawa Clinic, Gifu, Japan

    Taro Minagawa

  4. Gifu Municipal Hospital, Gifu, Japan

    Shinya Minatoguchi

  5. Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

    Okura Hiroyuki

Authors
  1. Shinichiro Tanaka
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  2. Tomonori Segawa
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  3. Toshiyuki Noda
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  4. Natsumi Tsugita
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  5. Takahiro Fuseya
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  6. Tomonori Kawaguchi
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  7. Makoto Iwama
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  8. Sachiro Watanabe
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  9. Taro Minagawa
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  10. Shinya Minatoguchi
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  11. Okura Hiroyuki
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Contributions

All the authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Tanaka S, Segawa T and Noda T. The first draft of the manuscript was written by Tanaka S and all the authors commented on previous versions of the manuscript. All the authors read and approved the final manuscript. All the authors read and approved the final manuscript.

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Correspondence to Shinichiro Tanaka.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval

This study was conducted according with the principles of the Declaration of Helsinki and Ethical Guidelines for Medical and Health Research Involving Human Subjects by the Ministry of Health, Labor, and Welfare and Ministry of Education, Culture, Sports, Science, and Technology of Japan. This study was approved by the Ethics Committee of Asahi University Hospital (approval number: 2019-11-06).

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Informed consent was obtained in the form of opt-out on Asahi University Hospital’s website for the study.

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Tanaka, S., Segawa, T., Noda, T. et al. Assessment of visit-to-visit variability in systolic blood pressure over 5 years and phasic left atrial function by two-dimensional speckle-tracking echocardiography. Heart Vessels 36, 827–835 (2021). https://doi.org/10.1007/s00380-020-01751-5

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  • DOI: https://doi.org/10.1007/s00380-020-01751-5

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