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Association of onset-season with characteristics and long-term outcomes in acute myocardial infarction patients: results from the Japanese registry of acute myocardial infarction diagnosed by universal definition (J-MINUET) substudy

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Abstract

It is known that incidence and short-term mortality rate of acute myocardial infarction (AMI) tend to be higher in the cold season. The aim of our study was to investigate the association of onset-season with patient characteristics and long-term prognosis of AMI. This was a prospective, multicenter, Japanese investigation of 3,283 patients with AMI who were hospitalized within 48 h of symptom onset between July 2012 and March 2014. Patients were divided into 3 seasonal groups according to admission date: cold season group (December–March), hot season group (June–September), and moderate season group (April, May, October, and November). We identified 1356 patients (41.3%) admitted during the cold season, 901 (27.4%) during the hot season, and 1026 (31.3%) during the moderate season. We investigated the seasonal effect on patient characteristics and clinical outcomes. Baseline characteristics of each seasonal group were comparable, with the exception of age, Killip class, and conduction disturbances. The rates of higher Killip class and complete atrioventricular block were significantly higher in the cold season group. The 3-year cumulative survival free from major adverse cardiac events (MACE) rate was the lowest in the cold season (67.1%), showing a significant difference, followed by the moderate (70.0%) and hot seasons (72.9%) (p < 0.01). Initial severity and long-term prognoses were worse in patients admitted during the cold season. Our findings highlight the importance of optimal prevention and follow-up of AMI patients with cold season onset.

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References

  1. Spencer FA, Goldberg RJ, Becker RC, Gore JM (1998) Seasonal distribution of acute myocardial infarction in the second National Registry of Myocardial Infarction. J Am Coll Cardiol 31:1226–1233

    Article  CAS  Google Scholar 

  2. Ornato JP, Peberdy MA, Chandra NC, Bush DE (1996) Seasonal pattern of acute myocardial infarction in the National Registry of Myocardial Infarction. J Am Coll Cardiol 28:1684–1688

    Article  CAS  Google Scholar 

  3. Spielberg C, Falkenhahn D, Willich SN, Wegscheider K, Voller H (1996) Circadian, day-of-week, and seasonal variability in myocardial infarction: comparison between working and retired patients. Am Heart J 132:579–585

    Article  CAS  Google Scholar 

  4. Enquselassie F, Dobson AJ, Alexander HM, Steele PL (1993) Seasons, temperature and coronary disease. Int J Epidemiol 22:632–636

    Article  CAS  Google Scholar 

  5. Kinoshita N, Imai K, Kinjo K, Naka M (2005) Longitudinal study of acute myocardial infarction in the southeast Osaka district from 1988 to 2002. Circ J 69:1170–1175

    Article  Google Scholar 

  6. Rumana N, Kita Y, Turin TC, Murakami Y, Sugihara H, Morita Y, Tomioka N, Okayama A, Nakamura Y, Ueshima H (2008) Seasonal pattern of incidence and case fatality of acute myocardial infarction in a Japanese population (from the Takashima AMI Registry, 1988 to 2003). Am J Cardiol 102:1307–1311

    Article  Google Scholar 

  7. Mohammadian-Hafshejani A, Sarrafzadegan N, Hosseini S, Baradaran HR, Roohafza H, Sadeghi M, Asadi-Lari M (2014) Seasonal pattern in admissions and mortality from acute myocardial infarction in elderly patients in Isfahan. Iran. ARYA Atheroscler 10:46–54

    PubMed  Google Scholar 

  8. Ishihara M, Fujino M, Ogawa H, Yasuda S, Noguchi T, Nakao K, Ozaki Y, Kimura K, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Tsujita K, Nishimura K, Miyamoto Y (2015) Clinical Presentation, Management and Outcome of Japanese Patients With Acute Myocardial Infarction in the Troponin Era - Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET). Circ J 79:1255–1262

    Article  Google Scholar 

  9. Ishihara M, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Fujino M, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Uematsu M, Hirata K, Tanabe K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Tobaru T, Oshima S, Nakai M, Nishimura K, Miyamoto Y, Ogawa H, Investigators JM (2017) Long-Term Outcomes of Non-ST-Elevation Myocardial Infarction Without Creatine Kinase Elevation- The J-MINUET Study. Circ J 81:958–965

    Article  Google Scholar 

  10. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD et al (2012) Third universal definition of myocardial infarction. J Am Coll Cardiol 60:1581–1598

    Article  Google Scholar 

  11. Alpert JS, Thygesen K, Antman E, Bassand JP (2000) Myocardial infarction redefined–a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol 36:959–969

    Article  CAS  Google Scholar 

  12. American College of Emergency P, Society for Cardiovascular A, Interventions, O'Gara PT, Kushner FG, Ascheim DD, Casey DE, Jr., Chung MK, de Lemos JA, Ettinger SM, Fang JC, Fesmire FM, Franklin BA, Granger CB, Krumholz HM, Linderbaum JA, Morrow DA, Newby LK, Ornato JP, Ou N, Radford MJ, Tamis-Holland JE, Tommaso CL, Tracy CM, Woo YJ, Zhao DX, Anderson JL, Jacobs AK, Halperin JL, Albert NM, Brindis RG, Creager MA, DeMets D, Guyton RA, Hochman JS, Kovacs RJ, Kushner FG, Ohman EM, Stevenson WG, Yancy CW (2013) 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 61:e78–140

    Google Scholar 

  13. LeBlanc J, Cote J, Jobin M, Labrie A (1979) Plasma catecholamines and cardiovascular responses to cold and mental activity. J Appl Physiol 47:1207–1211

    Article  CAS  Google Scholar 

  14. Brennan PJ, Greenberg G, Miall WE, Thompson SG (1982) Seasonal variation in arterial blood pressure. BMJ 285:919–923

    Article  CAS  Google Scholar 

  15. MacMahon S, Peto R, Cutler J, Collins R, Sorlie P, Neaton J, Abbott R, Godwin J, Dyer A, Stamler J (1990) Blood pressure, stroke, and coronary heart disease. Part 1, Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet 335:765–774

    Article  CAS  Google Scholar 

  16. Mavri A, Guzic-Salobir B, Salobir-Pajnic B, Keber I, Stare J, Stegnar M (2001) Seasonal variation of some metabolic and haemostatic risk factors in subjects with and without coronary artery disease. Blood Coagul Fibrinolysis 12:359–365

    Article  CAS  Google Scholar 

  17. Gordon DJ, Trost DC, Hyde J, Whaley FS, Hannan PJ, Jacobs DR Jr, Ekelund LG (1987) Seasonal cholesterol cycles: the Lipid Research Clinics Coronary Primary Prevention Trial placebo group. Circulation 76:1224–1231

    Article  CAS  Google Scholar 

  18. Thomas CB, Holljes HW, Eisenberg FF (1961) Observations on seasonal variations in total serum cholesterol level among healthy young prisoners. Ann Intern Med 54:413–430

    Article  CAS  Google Scholar 

  19. Bull GM, Brozovic M, Chakrabarti R, Meade TW, Morton J, North WR, Stirling Y (1979) Relationship of air temperature to various chemical, haematological, and haemostatic variables. J Clin Pathol 32:16–20

    Article  CAS  Google Scholar 

  20. Stout RW, Crawford V (1991) Seasonal variations in fibrinogen concentrations among elderly people. Lancet 338:9–13

    Article  CAS  Google Scholar 

  21. Woodhouse PR, Khaw KT, Plummer M, Foley A, Meade TW (1994) Seasonal variations of plasma fibrinogen and factor VII activity in the elderly: winter infections and death from cardiovascular disease. Lancet 343:435–439

    Article  CAS  Google Scholar 

  22. Boulay F, Berthier F, Sisteron O, Gendreike Y, Gibelin P (1999) Seasonal variation in chronic heart failure hospitalizations and mortality in France. Circulation 100:280–286

    Article  CAS  Google Scholar 

  23. Stewart S, McIntyre K, Capewell S, McMurray JJ (2002) Heart failure in a cold climate. Seasonal variation in heart failure-related morbidity and mortality. J Am Coll Cardiol 39:760–766

    Article  Google Scholar 

  24. Martinez-Selles M, Garcia Robles JA, Prieto L, Serrano JA, Munoz R, Frades E, Almendral J (2002) Annual rates of admission and seasonal variations in hospitalizations for heart failure. Eur J Heart Fail 4:779–786

    Article  Google Scholar 

  25. Hirai M, Kato M, Kinugasa Y, Sugihara S, Yanagihara K, Yamada K, Watanabe T, Yamamoto K (2015) Clinical scenario 1 is associated with winter onset of acute heart failure. Circ J 79:129–135

    Article  CAS  Google Scholar 

  26. Nakaji S, Parodi S, Fontana V, Umeda T, Suzuki K, Sakamoto J, Fukuda S, Wada S, Sugawara K (2004) Seasonal changes in mortality rates from main causes of death in Japan (1970–1999). Eur J Epidemiol 19:905–913

    Article  Google Scholar 

  27. Liu IF, Chang SL, Lo LW, Hu YF, Tuan TC, Kong CW, Wu TJ, Chiang CE, Chen SA, Lin YJ (2011) Relationship between temperature change and the requirement for a permanent pacemaker implantation in bradyarrhythmias. Int J Biometeorol 55:733–739

    Article  Google Scholar 

  28. Palmisano P, Accogli M, Zaccaria M, Vergari A, De Masi Gde L, Negro L, De Blasi S (2014) Relationship between seasonal weather changes, risk of dehydration, and incidence of severe bradyarrhythmias requiring urgent temporary transvenous cardiac pacing in an elderly population. Int J Biometeorol 58:1513–1520

    Article  Google Scholar 

  29. Sharovsky R, António L, César M (2002) Increase in mortality due to myocardial infarction in the Brazilian city of Sao Paulo during winter. Arq Bras Cardiol 78:106–109

    Article  Google Scholar 

  30. Dilaveris P, Synetos A, Giannopoulos G, Gialafos E, Pantazis A, Stefanadis C (2006) CLimate impacts on myocardial infarction deaths in the athens territory: the climate study. Heart 92:1747–1751

    Article  CAS  Google Scholar 

  31. Sheth T, Nair C, Muller J, Yusuf S (1999) Increased winter mortality from acute myocardial infarction and stroke: the effect of age. J Am Coll Cardio 33:1916–1919

    Article  CAS  Google Scholar 

  32. Vasconcelos J, Freire E, Almendra R, Silva GL, Santana P (2013) The impact of winter cold weather on acute myocardial infarctions in Portugal. Environ Pollut 183(1873–6424):14–18

    Article  CAS  Google Scholar 

  33. Ahlbom A (1979) Seasonal variations in the incidence of acute myocardial infarction in Stockholm. Scand J Soc Med 7:127–130

    Article  CAS  Google Scholar 

  34. Sarna S, Romo M, Siltanen P (1977) Myocardial infarction and weather. Ann Clin Res 9:222–232

    CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The authors thank all the enrolled patients, participating cardiologists, medical and other staffs who have contributed to this study. This study was supported by the Intramural Research Fund, grant number 23–4-5, for Cardiovascular Diseases of the National Cerebral and Cardiovascular Center.

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Authors and Affiliations

  1. Division of Cardiology, Mitsui Memorial Hospital, Kanda-Izumicho 1, Chiyoda-ku, Tokyo, 101-8643, Japan

    Taishi Okuno, Jiro Aoki & Kengo Tanabe

  2. Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Centre, Kumamoto, Japan

    Koichi Nakao

  3. Department of Cardiology, Fujita Health University Hospital, Toyoake, Japan

    Yukio Ozaki

  4. Cardiovascular Centre, Yokohama City University Medical Centre, Yokohama, Japan

    Kazuo Kimura

  5. Department of Cardiovascular Medicine, Kitasato University, Tokyo, Japan

    Junya Ako

  6. Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Centre, Osaka, Japan

    Teruo Noguchi & Satoshi Yasuda

  7. Department of Cardiology, Juntendo University Shizuoka Hospital, Shizuoka, Japan

    Satoru Suwa

  8. Department of Cardiology, National Hospital Organization Kumamoto Medical Centre, Kumamoto, Japan

    Kazuteru Fujimoto

  9. Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan

    Yasuharu Nakama

  10. Division of Cardiology, Osaka General Medical Centre, Osaka, Japan

    Takashi Morita

  11. Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan

    Wataru Shimizu

  12. First Department of Internal Medicine, Nara Medical University, Nara, Japan

    Yoshihiko Saito

  13. Department of Cardiovascular Medicine, The Sakakibara Heart Institute of Okayama, Okayama, Japan

    Atsushi Hirohata

  14. Department of Cardiology, Ogaki Municipal Hospital, Ogaki, Japan

    Yasuhiro Morita

  15. Department of Cardiovascular Medicine, Dokkyo Medical University, Tochigi, Japan

    Teruo Inoue

  16. Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan

    Atsunori Okamura

  17. Cardiovascular Centre, Kansai Rosai Hospital, Hyogo, Japan

    Toshiaki Mano

  18. Department of Cardiology, Okinawa Prefectural Chubu Hospital, Uruma, Japan

    Kazuhito Hirata

  19. Department of Cardiology, Miyazaki Medical Association Hospital, Miyazaki, Japan

    Yoshisato Shibata

  20. Department of Cardiovascular Medicine, Suwa Red Cross Hospital, Nagano, Japan

    Mafumi Owa

  21. Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

    Kenichi Tsujita

  22. Division of Cardiovascular Medicine, Saitama Medical Centre, Jichi Medical University, Tochigi, Japan

    Hiroshi Funayama

  23. Department of Cardiovascular, Renal and Medabolic Medicine, Sapporo Medical School, Sapporo, Japan

    Nobuaki Kokubu

  24. Department of Cardiology, Teikyo University, Tokyo, Japan

    Ken Kozuma

  25. Department of Cardiology, Kawasaki Medical School, Matsushima, Japan

    Shiro Uemura

  26. Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan

    Tetsuya Tobaru

  27. Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan

    Keijiro Saku

  28. Department of Cardiology, Gunma Prefectural Cardiovascular Centre, Maebashi, Japan

    Shigeru Ohshima

  29. Department of Preventive Cardiology, National Cerebral and Cardiovascular Centre, Osaka, Japan

    Kunihiro Nishimura & Yoshihiro Miyamoto

  30. National Cerebral and Cardiovascular Centre, Osaka, Japan

    Hisao Ogawa

  31. Division of Coronary Artery Disease, Hyogo College of Medicine, Nishinomiya, Japan

    Masaharu Ishihara

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  1. Taishi Okuno
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  2. Jiro Aoki
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  3. Kengo Tanabe
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  33. Yoshihiro Miyamoto
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  34. Hisao Ogawa
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  35. Masaharu Ishihara
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Correspondence to Kengo Tanabe.

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Okuno, T., Aoki, J., Tanabe, K. et al. Association of onset-season with characteristics and long-term outcomes in acute myocardial infarction patients: results from the Japanese registry of acute myocardial infarction diagnosed by universal definition (J-MINUET) substudy. Heart Vessels 34, 1899–1908 (2019). https://doi.org/10.1007/s00380-019-01426-w

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