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A case of IgG4-related lymphadenopathy, pericarditis, coronary artery periarteritis and luminal stenosis

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Abstract

Immunoglobulin G4 (IgG4)-related disease is an emerging new clinicopathological disorder that is characterized by elevation of serum IgG4 levels and histological findings of IgG4-positive plasmacytic infiltration. IgG4-related disease may appear synchronously or metachronously in a wide variety of organs. The current patient was found to have pericardial effusion and retroperitoneal fibrosis. He was subsequently diagnosed with coronary artery stenosis. 18F-FDG positron emission tomography showed enhanced FDG uptake in lymph nodes as well as pericardial and peri-aortic tissue. Histopathology of the mediastinal lymph node showed the infiltration of numerous IgG4-positive cells, leading to the diagnosis of IgG4-related lymphadenopathy with pericardial and periarterial involvement.

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Authors and Affiliations

  1. Department of Cardiology, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka, 569-8686, Japan

    Ryoto Hourai, Masatoshi Miyamura, Ryunosuke Tasaki, Akiko Iwata, Yoshihiro Takeda, Hideaki Morita, Jun Tanigawa, Kensaku Shibata & Nobukazu Ishizaka

  2. Department of Thoracic Surgery, Osaka Medical College, Osaka, Japan

    Nobuharu Hanaoka

  3. Department of Pathology, Osaka Medical College, Osaka, Japan

    Atsushi Takeshita & Yoshinobu Hirose

  4. Division of Rheumatology, Department of Internal Medicine, Kanazawa University Hospital, Kanazawa, Japan

    Mitsuhiro Kawano

  5. Department of Pathology, Okayama University Graduate School of Medicine, Okayama, Japan

    Yasuharu Sato

Authors
  1. Ryoto Hourai
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  2. Masatoshi Miyamura
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  3. Ryunosuke Tasaki
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  4. Akiko Iwata
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  5. Yoshihiro Takeda
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  6. Hideaki Morita
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  7. Nobuharu Hanaoka
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  8. Jun Tanigawa
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  9. Kensaku Shibata
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  10. Atsushi Takeshita
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  11. Mitsuhiro Kawano
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  12. Yasuharu Sato
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  13. Yoshinobu Hirose
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  14. Nobukazu Ishizaka
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Corresponding author

Correspondence to Nobukazu Ishizaka.

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Hourai, R., Miyamura, M., Tasaki, R. et al. A case of IgG4-related lymphadenopathy, pericarditis, coronary artery periarteritis and luminal stenosis. Heart Vessels 31, 1709–1713 (2016). https://doi.org/10.1007/s00380-016-0794-1

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  • DOI: https://doi.org/10.1007/s00380-016-0794-1

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