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Characterization of cardiac oxidative stress levels in patients with atrial fibrillation

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Abstract

Atrial fibrillation (AF) is associated with oxidative stress and elevated brain natriuretic peptide (BNP) levels. However, the exact cardiac origin of oxidative stress and its association with BNP levels in AF patients remain unclear. Therefore, we investigated the chamber-specific plasma oxidative stress levels in patients with paroxysmal AF (PAF) and persistent AF (PSAF). Diacron-reactive oxygen metabolite (dROM) levels were measured in patients with PAF (n = 50) and PSAF (n = 35) at different cardiac sites before ablation and in peripheral vein 3 months after ablation. For all sites, dROM levels were higher in PSAF patients than in PAF patients; the levels were the highest in the coronary sinus at 429.0 (interquartile range: 392.0–449.0) vs. 374.0 (357.0–397.8) Carratelli units (P < 0.05). dROM levels in the coronary sinus were related to the BNP levels (r = 0.436, P < 0.001). Furthermore, the reduction in the peripheral dROM levels was related to that in the peripheral BNP levels in patients with symptomatic improvement (r = 0.473, P < 0.001). Cardiac oxidative stress may either be a cause or consequence of prolonged AF, and cardiac oxidative stress levels correlated with BNP levels, though a possible source of oxidative stress in AF patients may be systemic circulation.

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Acknowledgments

We thank Minako Aono, Yuka Ichihara, Kazuko Misawa, Kayo Kobayashi, and Mebae Kobayashi for their excellent technical assistance.

Conflict of interest

The authors have no conflicts of interest and no sources of financial support to declare.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan

    Ayako Okada, Yuichiro Kashima, Takeshi Tomita, Takahiro Takeuchi, Kazunori Aizawa & Uichi Ikeda

  2. Division of Bio-Imaging, Jichi Medical University, Tochigi, Japan

    Masafumi Takahashi

Authors
  1. Ayako Okada
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  2. Yuichiro Kashima
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  3. Takeshi Tomita
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  4. Takahiro Takeuchi
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  5. Kazunori Aizawa
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  6. Masafumi Takahashi
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  7. Uichi Ikeda
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Corresponding author

Correspondence to Yuichiro Kashima.

Additional information

A. Okada and Y. Kashima have equally contributed to this work.

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Okada, A., Kashima, Y., Tomita, T. et al. Characterization of cardiac oxidative stress levels in patients with atrial fibrillation. Heart Vessels 31, 80–87 (2016). https://doi.org/10.1007/s00380-014-0582-8

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  • DOI: https://doi.org/10.1007/s00380-014-0582-8

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