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Lower 1,5-anhydroglucitol is associated with denovo coronary artery disease in patients at high cardiovascular risk

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Abstract

Postprandial hyperglycemia is a risk factor for cardiovascular disease and mortality. Serum 1,5-anhydroglucitol (1,5-AG) level is an useful clinical marker of glucose metabolism which reflects postprandial hyperglycemia more robustly compared to hemoglobin A1c (HbA1c). Relationship between serum 1,5-AG level and cardiovascular disease has been reported; however, comparison between HbA1c and 1,5-AG as markers of cardiovascular disease was not performed. We included 227 consecutive patients who underwent coronary angiography meeting the following inclusion criteria: (1) patients who had no history of coronary artery disease (CAD); (2) patients without acute coronary syndrome; (3) patients without poorly controlled diabetes mellitus; (4) patients without anemia, liver dysfunction, acute, and chronic renal failure and malnutrition; and (5) patients without adhibition of acarbose or Chinese herbal medicine. We measured HbA1c, glycoalbumin, and 1,5-AG. Serum 1,5-AG was significantly lower in patients with CAD (16.6 ± 8.50 vs. 21.1 ± 7.97 μg/ml, P < 0.001). Multivariable logistic regression analysis showed decrease in serum 1,5-AG was independently associated with the presence of denovo CAD (0.93, 95 % CI 0.88–0.98, P = 0.006). Serum 1,5-AG was also independently associated with the presence of denovo CAD in patients without diabetes mellitus (0.94, 95 % CI 0.88–0.99, P = 0.046). In conclusion, lower serum 1,5-AG was associated with the presence of denovo CAD. Serum 1,5-AG may identify high cardiovascular risk patients for denovo CAD in both diabetic and non-diabetic patients.

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Acknowledgments

We thank staff at our hospital for assistance in sample collection and patients for their participation in the study.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, Saitama, Saitama, 330-8503, Japan

    Takayuki Fujiwara, Takunori Tsukui, Tomohiro Nakamura, Kenichi Sakakura, Hiroshi Wada, Kenshiro Arao, Takuji Katayama, Hiroshi Funayama, Yoshitaka Sugawara, Takeshi Mitsuhashi & Shin-ichi Momomura

  2. Department of Endocrinology and Metabolism, Saitama Medical Center, Jichi Medical University, Saitama, Japan

    Masashi Yoshida, Hodaka Yamada & Masafumi Kakei

  3. Department of Cardiovascular Medicine, Kitasato University, Tokyo, Japan

    Junya Ako

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  1. Takayuki Fujiwara
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  14. Shin-ichi Momomura
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Correspondence to Shin-ichi Momomura.

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Fujiwara, T., Yoshida, M., Yamada, H. et al. Lower 1,5-anhydroglucitol is associated with denovo coronary artery disease in patients at high cardiovascular risk. Heart Vessels 30, 469–476 (2015). https://doi.org/10.1007/s00380-014-0502-y

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  • DOI: https://doi.org/10.1007/s00380-014-0502-y

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