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Prolonged pain to hospital time is associated with increased plasma advanced oxidation protein products and poor prognosis in patients with percutaneous coronary intervention for ST-elevation myocardial infarction

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Abstract

Plasma advanced oxidation protein products (AOPP) are a biomarker for increased production of reactive oxygen species. We examined the possible association between pain to hospital time, plasma AOPP, and outcome of patients receiving percutaneous coronary intervention (PCI) for ST-elevation acute myocardial infarction (STEMI). Plasma AOPP was determined at hospitalization as well as 24 and 48 h after PCI in 79 patients with suspected STEMI. Patients were stratified into a control group (Group I, n = 21) after exclusion of coronary artery disease, Group II (n = 46) with pain to hospital time <12 h, and Group III (n = 33) with pain to hospital time >12 h. Associations between pain to hospital time and AOPP as well as incidence of major adverse cardiac events (MACE) during 6 months of follow-up were analyzed. Plasma AOPP at admission was significantly higher in patients of Group II (97.58 ± 23.41 μmol/l) and Group III (184.52 ± 30.41 μmol/l) in comparison with Group I (57.41 ± 13.60 μmol/l, all P < 0.001). Plasma AOPP concentration was positively correlated with pain to hospital time and associated with an increased incidence of MACE during the 6-month follow-up period. Prolonged ischemia is associated with increased oxidative stress and poor prognosis in patients treated with PCI for STEMI.

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Authors and Affiliations

  1. Department of Cardiology, Zhongda Hospital, Southeast University, 87 Dingjiaqiao Street, Nanjing, 210009, PR China

    Yi Feng, Chengxing Shen, Genshan Ma, Jihui Wang, Zhong Chen, Qiming Dai, Hong Zhi, Chengjian Yang, Qiang Fu, Gensheng Shang & Yuanyuan Guan

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  1. Yi Feng
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  2. Chengxing Shen
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  3. Genshan Ma
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  4. Jihui Wang
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  5. Zhong Chen
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  6. Qiming Dai
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  7. Hong Zhi
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  8. Chengjian Yang
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  9. Qiang Fu
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  10. Gensheng Shang
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  11. Yuanyuan Guan
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Correspondence to Genshan Ma.

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These authors contributed equally to this article.

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Feng, Y., Shen, C., Ma, G. et al. Prolonged pain to hospital time is associated with increased plasma advanced oxidation protein products and poor prognosis in patients with percutaneous coronary intervention for ST-elevation myocardial infarction. Heart Vessels 25, 374–378 (2010). https://doi.org/10.1007/s00380-009-1220-8

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  • DOI: https://doi.org/10.1007/s00380-009-1220-8

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