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The use of H1-receptor antagonists and left ventricular remodeling in patients on chronic hemodialysis

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Abstract

Suppression of left ventricular (LV) remodeling secondary to heart failure seems critical to improve the prognosis of hemodialysis (HD) patients. This is a retrospective study on the relationship of an antiallergic drug and antihistamines with LV hypertrophy. A total of 149 patients (88 males and 61 females) were entered in the study. Mean age was 66.7 years and mean duration of dialysis 14.4 years. Twenty-three patients received oral treatment with an antiallergic drug or second-generation antihistamines, 3 with the antiallergic drug and 20 with antihistamines. The multivariate analysis using LV mass index (LVMI) as the objective variable extracted the following independent factors: male sex, erythropoietin (EPO)/w, uric acid (UA), total cholesterol, antihistamines, antiallergic drug, and calcium channel blocker (CCB), with a standard regression coefficient of 0.187, 0.196, 0.212, −0.262, −0.215, −0.149 and −0.173, respectively. This study suggests a suppressive role of second-generation antihistamines on LV remodeling. Male sex, high-dose EPO/w, and elevated UA were considered as aggravating factors, and CCB as a suppressive factor.

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Authors and Affiliations

  1. Department of Internal Medicine, Yoshikawa Hospital, Tokyo, Japan

    Kiyotsugu Omae & Masao Yoshikawa

  2. Department of Medicine, Kidney Center, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Kiyotsugu Omae, Tetsuya Ogawa & Kosaku Nitta

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  1. Kiyotsugu Omae
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  2. Tetsuya Ogawa
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  3. Masao Yoshikawa
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  4. Kosaku Nitta
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Correspondence to Tetsuya Ogawa.

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Omae, K., Ogawa, T., Yoshikawa, M. et al. The use of H1-receptor antagonists and left ventricular remodeling in patients on chronic hemodialysis. Heart Vessels 25, 163–169 (2010). https://doi.org/10.1007/s00380-009-1183-9

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  • DOI: https://doi.org/10.1007/s00380-009-1183-9

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