Skip to main content

Advertisement

SpringerLink
Log in

Relationship of the percentage of circulating endothelial progenitor cell to the severity of coronary artery disease

  • Original Article
  • Published:
Heart and Vessels Aims and scope Submit manuscript

Abstract

Previous study demonstrated that the percentage of circulating endothelial progenitor cells was reduced in patients with coronary artery disease. However, the relationship of the percentage of circulating endothelial progenitor cells to the severity of coronary artery disease has not been investigated. The percentages of circulating endothelial progenitor cells were measured in 78 consecutive patients with unstable angina, as well as in 32 healthy volunteers. Dual-stained cells expressing CD34 and vascular endothelial growth factor receptor-2 were judged to be endothelial progenitor cells and were analyzed using flow cytometry. On stepwise multiple linear regression analysis, the percentages of circulating endothelial progenitor cells were independently decreased in patients with unstable coronary artery disease compared with those in the healthy volunteers (P < 0.05). Among patients with unstable coronary artery disease, the percentage of patients with at least one occluded vessel was significantly higher in patients with multi-vessel disease than in patients with single-vessel disease (P < 0.04). On stepwise multiple linear regression analysis, the percentages of circulating endothelial progenitor cells were independently decreased in patients with multi-vessel coronary artery disease compared with those in patients with single-vessel coronary artery disease (P < 0.03). Among patients with unstable coronary artery disease, the percentage of circulating endothelial progenitor cells was significantly related to the severity of coronary artery disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA, Finkel T (2003) Circulation endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 348:593–600

    Article  PubMed  Google Scholar 

  2. Werner N, Priller J, Laufs U, Endres M, Böhm M, Dirnagl U, Nickenig G (2002) Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation: effect of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition. Arterioscler Thromb Vasc Biol 22:1567–1572

    Article  PubMed  CAS  Google Scholar 

  3. Werner N, Junk S, Laufs U, Link A, Walenta K, Bohm M, Nickenig G (2003) Intravenous transfusion of endothelial progenitor cells reduces neointima formation after vascular injury. Circ Res 93:e17–e24

    Article  PubMed  CAS  Google Scholar 

  4. Dimmeler S, Zeiher AM (2004) Vascular repair by circulating endothelial progenitor cells: the missing link in atherosclerosis? J Mol Med 82:671–677

    Article  PubMed  Google Scholar 

  5. Vasa M, Fichtlscherer S, Adler K, Aicher A, Martin H, Zeiher AM, Dimmeler S (2001) Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease. Circulation 103:2885–2890

    Article  PubMed  CAS  Google Scholar 

  6. Hermiller JB, Cusma JT, Spero LA, Fortin DF, Harding MB, Bashore TM (1992) Quantitative and qualitative coronary angiographic analysis: review of methods, utility, and limitations. Cathet Cardiovasc Diagn 25:110–131

    Article  PubMed  CAS  Google Scholar 

  7. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T (1997) Isolation of putative progenitor endothelial cells for angiogenesis. Science 275:964–967

    Article  PubMed  CAS  Google Scholar 

  8. Dimmeler S, Haendeler J, Galle J, Zeiher AM (1997) Oxidized low-density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases: a mechanistic clue to the “response to injury” hypothesis. Circulation 95:1760–1763

    PubMed  CAS  Google Scholar 

  9. Escargueil-Blanc I, Meilhac O, Pieraggi MT, Arnal JF, Salvayre R, Negre-Salvayre A (1997) Oxidized LDLs induce massive apoptosis of cultured human endothelial cells through a calcium-dependent pathway: prevention by aurintricarboxylic acid. Arterioscler Thromb Vasc Biol 1997;17:331–339

    PubMed  CAS  Google Scholar 

  10. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis (2002) Circulation 105:1135–1143

    Article  PubMed  CAS  Google Scholar 

  11. Rosenzweig A. Endothelial progenitor cells (2003) N Engl J Med 348:581–582

    Article  PubMed  Google Scholar 

  12. Tangurek B, Ozer N, Sayar N, Terzi S, Yilmaz H, Dayi SU, Ciloglu F, Aksu H, Asilturk R, Cagil A (2006) The relationship between endothelial nitric oxide synthase gene polymorphism (T-786 C) and coronary artery disease in the Turkish population. Heart Vessels 21:285–290

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta Pei Road, Niao Sung Hsiang, Kaohsiung Hsien, 83301, Taiwan

    Mien-Cheng Chen, Chien-Jen Chen, Cheng-Hsu Yang, Wen-Hao Liu, Chih-Yuan Fang & Yuan-Kai Hsieh

  2. Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan

    Hsueh-Wen Chang

Authors
  1. Mien-Cheng Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chien-Jen Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Cheng-Hsu Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Wen-Hao Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Chih-Yuan Fang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yuan-Kai Hsieh
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hsueh-Wen Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mien-Cheng Chen.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chen, MC., Chen, CJ., Yang, CH. et al. Relationship of the percentage of circulating endothelial progenitor cell to the severity of coronary artery disease. Heart Vessels 23, 47–52 (2008). https://doi.org/10.1007/s00380-007-1006-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00380-007-1006-9

Key words

Search

Navigation