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Invertebrate trypsins: a review

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Abstract

Food protein hydrolysis, a crucial step in digestion, is catalyzed by trypsin enzymes from the digestive apparatus of invertebrates. Trypsin appeared early in evolution and occurs in all phyla and, in the digestive systems of invertebrates, it became the most abundant proteinase. As in vertebrates, invertebrate trypsin is also present in several forms (isoenzymes). Its physiological importance in food protein digestion in several invertebrate species has emerged with compelling evidence; and several other physiological functions, such as regulation of digestive functions, are now settled. Recent advances in the knowledge of invertebrate trypsin synthesis, regulation, genetics, catalytic characteristics; structure, evolution, as well as inhibition, especially in non-Drosophilidae insects and in some crustaceans are reviewed. Most of the existing information is largely based on the use of several tools, including molecular techniques, to answer many still open questions and solve medical, agricultural, and food quality problems.

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Authors and Affiliations

  1. Centro de Investigación en Alimentación y Desarrollo, Carretera a la Victoria Km. 0.6, Hermosillo, Sonora, 83000, Mexico

    Adriana Muhlia-Almazán

  2. Centro de Investigaciones Biológicas del Noroeste (CIBNOR), Unidad Hermosillo, Hermosillo, Sonora, 83260, Mexico

    Arturo Sánchez-Paz

  3. Centro de Investigaciones Biológicas del Noroeste, Mar Bermejo 195, Col. Playa Palo de Santa Rita, La Paz, Baja California Sur, 23090, México

    Fernando L. García-Carreño

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  1. Adriana Muhlia-Almazán
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  2. Arturo Sánchez-Paz
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  3. Fernando L. García-Carreño
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Correspondence to Fernando L. García-Carreño.

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Communicated by H.V. Carey.

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Muhlia-Almazán, A., Sánchez-Paz, A. & García-Carreño, F.L. Invertebrate trypsins: a review. J Comp Physiol B 178, 655–672 (2008). https://doi.org/10.1007/s00360-008-0263-y

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