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Bilaterale diffuse uveale melanozytäre Proliferation bei metastasierendem Mammakarzinom

Bilateral diffuse uveal melanocytic proliferation in a patient with metastatic breast cancer

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Zusammenfassung

Eine 64-jährige Patientin mit metastasierendem Mammakarzinom stellte sich aufgrund einer mehrwöchigen beidseitigen Visusverschlechterung vor. Es zeigten sich beidseits fleckige Funduspigmentierungen, seröse Netzhautabhebungen sowie eine Katarakt. Nach Diagnose einer bilateralen diffusen uvealen melanozytären Proliferation (BDUMP) erfolgte bei Progression der Erkrankung eine Plasmapherese 3-mal wöchentlich über einen Zeitraum von 2 Wochen. Diese Therapie wurde bis auf das Auftreten peripherer Ödeme gut vertragen. Der Therapieeffekt konnte nicht bewertet werden, da die Patientin kurze Zeit später an ihrer Grunderkrankung verstarb. Es handelt sich um den ersten beschriebenen Fall einer BDUMP infolge eines Mammakarzinoms.

Abstract

A 64-year-old female patient with a history of metastatic breast cancer presented with bilateral deterioration of visual acuity over a period of several weeks. Examination revealed patchy fundus pigmentation, serous retinal detachment and cataract in both eyes. After diagnosis of a bilateral diffuse uveal melanocytic proliferation (BDUMP) and due to disease progression, a course of plasmapheresis three times a week over a period of 2 weeks was initiated. Apart from the occurrence of peripheral edemas the therapy was well-tolerated by the patient. Treatment success could not be evaluated because the patient died a short time later. This is the first reported case of BDUMP due to breast cancer.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. A.E. Höh, F.G. Holz und S. Dithmar geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Authors and Affiliations

  1. Universitäts-Augenklinik Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland

    A.E. Höh

  2. Universitäts-Augenklinik Bonn, Bonn, Deutschland

    F.G. Holz

  3. Augenklinik des Klinikums Wiesbaden, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Deutschland

    S. Dithmar

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  1. A.E. Höh
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  2. F.G. Holz
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  3. S. Dithmar
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Correspondence to A.E. Höh.

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Höh, A., Holz, F. & Dithmar, S. Bilaterale diffuse uveale melanozytäre Proliferation bei metastasierendem Mammakarzinom. Ophthalmologe 111, 961–964 (2014). https://doi.org/10.1007/s00347-014-3019-y

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  • DOI: https://doi.org/10.1007/s00347-014-3019-y

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