Skip to main content
Log in

Multiresistente Keime in der Augenheilkunde

Multiresistant bacteria in ophthalmology

  • Leitthema
  • Published:
Der Ophthalmologe Aims and scope Submit manuscript

Zusammenfassung

Eine zunehmende Bedrohung in der Medizin geht von Keimen aus, die gegen eine Vielzahl der verfügbaren Antibiotika resistent sind. Die wichtigsten multiresistenten Erreger (MRE) sind methicillinresistente S. aureus (MRSA), vancomycinresistente MRSA (VMRSA), vancomycinresistente Enterokokken (VRE), und Enterobacteriaceae mit „extented spectrum beta lactamase“ (ESBL). Insbesondere für MRSA und VRE sind Infektionen in allen Bereichen der Augenheilkunde möglich. Am häufigsten sind die Lider, die Tränenwege und die Augenoberfläche betroffen.

Abstract

Multidrug-resistant bacteria have emerged as an increasing threat in many areas of medicine. The most prominent multidrug-resistant pathogens are methicillin-resistant S. aureus (MRSA), vancomycin-resistant MRSA (VMRSA), vancomycin-resistant enterococci (VRE), and Enterobacteriaceae with extended-spectrum beta-lactamase (ESBL). In particular, MRSA and VRE cause infections seen in ophthalmology. The lids, lacrimal duct, and ocular surface are frequently involved.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  1. Anari S, Karagama YG, Fulton B, Wilson JA (2005) Neonatal disseminated methicillin-resistant Staphylococcus aureus presenting as orbital cellulitis. J Laryngol Otol 119:64–67

    Article  PubMed  Google Scholar 

  2. Apt L, Isenberg SJ, Yoshimori R et al (1995) The effect of povidone-iodine solution applied at the conclusion of ophthalmic surgery. Am J Ophthalmol 119:701–705

    CAS  PubMed  Google Scholar 

  3. Asbell PA, Colby KA, Deng S et al (2008) Ocular TRUST: nationwide antimicrobial susceptibility patterns in ocular isolates. Am J Ophthalmol 145:951–958

    Article  PubMed  Google Scholar 

  4. Asbell PA, Sahm DF, Shaw M et al (2008) Increasing prevalence of methicillin resistance in serious ocular infections caused by Staphylococcus aureus in the United States: 2000 to 2005. J Cataract Refract Surg 34:814–818

    Article  PubMed  Google Scholar 

  5. Blomquist PH (2006) Methicillin-resistant Staphylococcus aureus infections of the eye and orbit (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc 104:322–345

    PubMed  Google Scholar 

  6. Charbonneau P, Parienti JJ, Thibon P et al (2006) Fluoroquinolone use and methicillin-resistant Staphylococcus aureus isolation rates in hospitalized patients: a quasi experimental study. Clin Infect Dis 42:778–784

    Article  CAS  PubMed  Google Scholar 

  7. Chiang RK, Rapuano CJ (2002) Recurrent methicillin-resistant Staphylococcus aureus wound ulcer after clear-cornea cataract surgery. Clao J 28:109–110

    PubMed  Google Scholar 

  8. Ciulla TA, Starr MB, Masket S (2002) Bacterial endophthalmitis prophylaxis for cataract surgery: an evidence-based update. Ophthalmology 109:13–24

    Article  PubMed  Google Scholar 

  9. Deramo VA, Lai JC, Winokur J et al (2008) Visual outcome and bacterial sensitivity after methicillin-resistant Staphylococcus aureus-associated acute endophthalmitis. Am J Ophthalmol 145:413–417

    Article  PubMed  Google Scholar 

  10. Diekema D, Pfaller M, Schmitz F et al (2001) Survey of infections due to Staphylocoocal species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillance Program, 1997–1999. Clin Infect Dis 32:S114–S132

    Article  CAS  PubMed  Google Scholar 

  11. Diekema DJ, Pfaller MA, Schmitz FJ et al (2001) Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillance Program, 1997–1999. Clin Infect Dis 32(Suppl 2):S114–S132

    Article  CAS  PubMed  Google Scholar 

  12. Esmaeli B, Holz ER, Ahmadi MA et al (2003) Endogenous endophthalmitis secondary to vancomycin-resistant enterococci infection. Retina 23:118–119

    Article  PubMed  Google Scholar 

  13. Farr B (2004) Prevention and control of methicillin-resistant Staphylococcus aureus infections. Curr Opin Infect Dis 17:317–322

    Article  PubMed  Google Scholar 

  14. Feiz V, Redline DE (2007) Infectious scleritis after pars plana vitrectomy because of methicillin-resistant Staphylococcus aureus resistant to fourth-generation fluoroquinolones. Cornea 26:238–240

    PubMed  Google Scholar 

  15. Forster W, Becker K, Hungermann D, Busse H (2002) Methicillin-resistant Staphylococcus aureus keratitis after excimer laser photorefractive keratectomy1. J Cataract Refract Surg 28:722–724

    Article  PubMed  Google Scholar 

  16. Freidlin J, Acharya N, Lietman TM et al (2007) Spectrum of eye disease caused by methicillin-resistant Staphylococcus aureus. Am J Ophthalmol 144:313–315

    Article  PubMed  Google Scholar 

  17. Fukuda M, Ohashi H, Matsumoto C et al (2002) Methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative Staphylococcus ocular surface infection efficacy of chloramphenicol eye drops. Cornea 21:S86–S89

    Article  PubMed  Google Scholar 

  18. Hidron AI, Kourbatova EV, Halvosa JS et al (2005) Risk factors for colonization with methicillin-resistant Staphylococcus aureus (MRSA) in patients admitted to an urban hospital: emergence of community-associated MRSA nasal carriage. Clin Infect Dis 41:159–166

    Article  PubMed  Google Scholar 

  19. Hiramatsu K, Hanaki H, Ino T et al (1997) Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility. J Antimicrob Chemother 40:135–136

    Article  CAS  PubMed  Google Scholar 

  20. Howe RA, Monk A, Wootton M et al (2004) Vancomycin susceptibility within methicillin-resistant Staphylococcus aureus lineages. Emerg Infect Dis 10:855–857

    CAS  PubMed  Google Scholar 

  21. Itoh M, Aoyama T, Iemoto A et al (2001) Pharmaceutical investigation of vancomycin hydrochloride eye drops and their topical application to MRSA eye infection. Yakugaku Zasshi 121:433–439

    Article  CAS  PubMed  Google Scholar 

  22. Kato T, Hayasaka S (1998) Methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative staphylococci from conjunctivas of preoperative patients. Jpn J Ophthalmol 42:461–465

    Article  CAS  PubMed  Google Scholar 

  23. Kimura N, Sotozono C, Higashihara H et al (2007) Relationship between ocular surface infection or colonization of methicillin-resistant Staphylococcus aureus and nasal carriage. Nippon Ganka Gakkai Zasshi 111:504–508

    PubMed  Google Scholar 

  24. Klevens RM, Edwards JR, Tenover FC et al (2006) Changes in the epidemiology of methicillin-resistant Staphylococcus aureus in intensive care units in US hospitals, 1992–2003. Clin Infect Dis 42:389–391

    Article  PubMed  Google Scholar 

  25. Ko KS, Lee MY, Song JH et al (2008) Prevalence and characterization of extended-spectrum beta-lactamase-producing Enterobacteriaceae isolated in Korean hospitals. Diagn Microbiol Infect Dis

  26. Koo L, Chang EL (2007) Methicillin-resistant Staphylococcus aureus caruncle abscess. Ophthal Plast Reconstr Surg 23:160–161

    Article  PubMed  Google Scholar 

  27. Kotlus BS, Rodgers IR, Udell IJ (2005) Dacryocystitis caused by community-onset methicillin-resistant Staphylococcus aureus. Ophthal Plast Reconstr Surg 21:371–375

    Article  PubMed  Google Scholar 

  28. Kubo M, Sakuraba T, Arai Y, Nakazawa M (2002) Dacryocystorhinostomy for dacryocystitis caused by methicillin- resistant Staphylococcus aureus: report of four cases. Jpn J Ophthalmol 46:177–182

    Article  PubMed  Google Scholar 

  29. LeBlanc L, Pepin J, Toulouse K et al (2006) Fluoroquinolones and risk for methicillin-resistant Staphylococcus aureus, Canada. Emerg Infect Dis 12:1398–1405

    CAS  PubMed  Google Scholar 

  30. Lee JE, Oum BS, Choi HY, JS Lee (2007) Methicillin-resistant Staphylococcus aureus sclerokeratitis after pterygium excision. Cornea 26:744–746

    Article  PubMed  Google Scholar 

  31. Maguen E, Morgan MA (2007) A case of vancomycin-resistant enterococcus conjunctivitis and its clinically successful topical treatment. Cornea 26:223–224

    Article  PubMed  Google Scholar 

  32. Marangon FB, Miller D, Muallem MS et al (2004) Ciprofloxacin and levofloxacin resistance among methicillin-sensitive Staphylococcus aureus isolates from keratitis and conjunctivitis. Am J Ophthalmol 137:453–458

    Article  CAS  PubMed  Google Scholar 

  33. McKinley SH, Yen MT, Miller AM, Yen KG (2007) Microbiology of pediatric orbital cellulitis. Am J Ophthalmol 144:497–501

    Article  PubMed  Google Scholar 

  34. Mills DM, Bodman MG, Meyer DR, Morton AD 3rd (2007) The microbiologic spectrum of dacryocystitis: a national study of acute versus chronic infection. Ophthal Plast Reconstr Surg 23:302–306

    Article  PubMed  Google Scholar 

  35. Monnet DL, MacKenzie FM, Lopez-Lozano JM et al (2004) Antimicrobial drug use and methicillin-resistant Staphylococcus aureus, Aberdeen, 1996–2000. Emerg Infect Dis 10:1432–1441

    PubMed  Google Scholar 

  36. Moran GJ, Amii RN, Abrahamian FM, Talan DA (2005) Methicillin-resistant Staphylococcus aureus in community-acquired skin infections. Emerg Infect Dis 11:928–930

    PubMed  Google Scholar 

  37. Morita JE, Fujioka RS, Tice AD et al (2007) Survey of methicillin-resistant Staphylococcus aureus (MRSA) carriage in healthy college students, Hawaii. Hawaii Med J 66:213–215

    PubMed  Google Scholar 

  38. Moshirfar M, Marx D, Mirzaian G (2005) Endophthalmitis in patients using fourth-generation fluoroquinolones following phacoemulsification. J Cataract Refract Surg 31:1669–1670

    Article  PubMed  Google Scholar 

  39. Moshirfar M, Mirzaian G, Feiz V, Kang PC (2006) Fourth-generation fluoroquinolone-resistant bacterial keratitis after refractive surgery. J Cataract Refract Surg 32:515–518

    Article  PubMed  Google Scholar 

  40. Ness T, Reinhard T (2006) Perioperative antibiotics in phacoemulsification. J Cataract Refract Surg 32:705–706; author reply 706

    Article  PubMed  Google Scholar 

  41. Ness T, Schneider C (2009) Endogenous endophthalmitis caused by methicillin-resistant Staphylococcus aureus (MRSA). Retina 29:831–834

    Article  PubMed  Google Scholar 

  42. Noble W, Valkenburg H, Wolters C (1967) Carriage of Staphylococcus aureus in random samples of a normal population. Int J Hyg Environ Health 65:567–573

    CAS  Google Scholar 

  43. Nomi N, Morishige N, Yamada N et al (2008) Two cases of methicillin-resistant Staphylococcus aureus keratitis after Epi-LASIK. Jpn J Ophthalmol 52:440–443

    Article  PubMed  Google Scholar 

  44. Oksuz L, Gurler N (2009) Typing of extended-spectrum beta-lactamases in Escherichia coli and Klebsiella spp. strains and analysis of plasmid profiles. Mikrobiyol Bul 43:183–194

    CAS  PubMed  Google Scholar 

  45. Oshima Y, Ohji M, Inoue Y et al (1999) Methicillin-resistant Staphylococcus aureus infections after scleral buckling procedures for retinal detachments associated with atopic dermatitis. Ophthalmology 106:142–147

    Article  CAS  PubMed  Google Scholar 

  46. Oshitari K, Hirakata A, Okada AA et al (2003) Vitrectomy for endophthalmitis after cataract surgery. Nippon Ganka Gakkai Zasshi 107:590–596

    PubMed  Google Scholar 

  47. Richer SL, Wenig BL (2009) The efficacy of preoperative screening and the treatment of methicillin-resistant Staphylococcus aureus in an otolaryngology surgical practice. Otolaryngol Head Neck Surg 140:29–32

    Article  PubMed  Google Scholar 

  48. Rubinfeld RS, Negvesky GJ (2001) Methicillin-resistant Staphylococcus aureus ulcerative keratitis after laser in situ keratomileusis. J Cataract Refract Surg 27:1523–1525

    Article  CAS  PubMed  Google Scholar 

  49. Rutar T (2009) Vertically acquired community methicillin-resistant Staphylococcus aureus dacryocystitis in a neonate. J Aapos 13:79–81

    Article  PubMed  Google Scholar 

  50. Rutar T, Chambers HF, Crawford JB et al (2006) Ophthalmic manifestations of infections caused by the USA300 clone of community-associated methicillin-resistant Staphylococcus aureus. Ophthalmology 113:1455–1462

    Article  PubMed  Google Scholar 

  51. Rutar T, Zwick OM, Cockerham KP, Horton JC (2005) Bilateral blindness from orbital cellulitis caused by community-acquired methicillin-resistant Staphylococcus aureus. Am J Ophthalmol 140:740–742

    Article  PubMed  Google Scholar 

  52. Sakaki H, Nishioka M, Kanda K, Takahashi Y (2009) An investigation of the risk factors for infection with methicillin-resistant Staphylococcus aureus among patients in a neonatal intensive care unit. Am J Infect Control 37:580–586

    Article  PubMed  Google Scholar 

  53. Sakata H (2003) 10-yearly monitoring of prevalence of MRSA and antibiotic usage in a neonatal intensive care unit. Kansenshogaku Zasshi 77:24–28

    PubMed  Google Scholar 

  54. Shome D, Jain V, Natarajan S et al (2008) Community-acquired methicillin-resistant Staphylococcus aureus (CAMRSA) – a rare cause of fulminant orbital cellulitis. Orbit 27:179–181

    Article  PubMed  Google Scholar 

  55. Solomon R, Donnenfeld ED, Perry HD, Biser S (2003) Bilateral methicillin-resistant Staphylococcus aureus keratitis in a medical resident following an uneventful bilateral photorefractive keratectomy. Eye Contact Lens 29:187–189

    Article  PubMed  Google Scholar 

  56. Solomon R, Donnenfeld ED, Perry HD et al (2007) Methicillin-resistant Staphylococcus aureus infectious keratitis following refractive surgery. Am J Ophthalmol 143:629–634

    Article  PubMed  Google Scholar 

  57. Speaker MG, Menikoff JA (1991) Prophylaxis of endophthalmitis with topical povidone-iodine. Ophthalmology 98:1769–1775

    CAS  PubMed  Google Scholar 

  58. Stemper ME, Brady JM, Qutaishat SS et al (2006) Shift in Staphylococcus aureus clone linked to an infected tattoo. Emerg Infect Dis 12:1444–1446

    PubMed  Google Scholar 

  59. Tang CW, Cheng CK, Lee TS (2007) Community-acquired bleb-related endophthalmitis caused by vancomycin-resistant enterococci. Can J Ophthalmol 42:477–478

    Article  PubMed  Google Scholar 

  60. Tang HH, Yip PP, Woo CF et al (2008) Methicillin-resistant Staphylococcus aureus endophthalmitis after phacoemulsification in a continuous ambulatory peritoneal dialysis patient. J Cataract Refract Surg 34:1806–1808

    Article  PubMed  Google Scholar 

  61. Tazawa H, Ooishi M (1992) MRSA ocular infections. Nippon Rinsho 50:1122–1126

    CAS  PubMed  Google Scholar 

  62. Tiemersma EW, Bronzwaer SL, Lyytikainen O et al (2004) Methicillin-resistant Staphylococcus aureus in Europe, 1999-2002. Emerg Infect Dis 10:1627–1634

    PubMed  Google Scholar 

  63. Turabelidze G, Lin M, Wolkoff B et al (2006) Personal hygiene and methicillin-resistant Staphylococcus aureus infection. Emerg Infect Dis 12:422–427

    PubMed  Google Scholar 

  64. Wakimasu K, Sotozono C, Shimizu Y et al (2004) A retrospective analysis of infection after corneal transplantation. Nippon Ganka Gakkai Zasshi 108:354–358

    PubMed  Google Scholar 

  65. Watanabe K, Numata-Watanabe K, Hayasaka S (2001) Methicillin-resistant staphylococci and ofloxacin-resistant bacteria from clinically healthy conjunctivas. Ophthalmic Res 33:136–139

    Article  CAS  PubMed  Google Scholar 

  66. Weber SG, Gold HS, Hooper DC et al (2003) Fluoroquinolones and the risk for methicillin-resistant Staphylococcus aureus in hospitalized patients. Emerg Infect Dis 9:1415–1422

    PubMed  Google Scholar 

  67. Woodward M, Randleman JB (2007) Bilateral methicillin-resistant Staphylococcus aureus keratitis after photorefractive keratectomy. J Cataract Refract Surg 33:316–319

    Article  PubMed  Google Scholar 

  68. Wroblewski KJ, Pasternak JF, Bower KS et al (2006) Infectious keratitis after photorefractive keratectomy in the United States army and navy. Ophthalmology 113:520–525

    Article  PubMed  Google Scholar 

  69. Zahar JR, Clec’h C, Tafflet M et al (2005) Is methicillin resistance associated with a worse prognosis in Staphylococcus aureus ventilator-associated pneumonia? Clin Infect Dis 41:1224–1231

    Article  PubMed  Google Scholar 

  70. Zinderman CE, Conner B, Malakooti MA et al (2004) Community-acquired methicillin-resistant Staphylococcus aureus among military recruits. Emerg Infect Dis 10:941–944

    PubMed  Google Scholar 

  71. Zoumalan RA, Rosenberg DB (2008) Methicillin-resistant Staphylococcus aureus – positive surgical site infections in face-lift surgery. Arch Facial Plast Surg 10:116–123

    Article  PubMed  Google Scholar 

Download references

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to T. Neß.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Neß, T. Multiresistente Keime in der Augenheilkunde. Ophthalmologe 107, 318–322 (2010). https://doi.org/10.1007/s00347-009-2076-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00347-009-2076-0

Schlüsselwörter

Keywords

Navigation