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Sexualhormone und trockenes Auge

Sex hormones and dry eye

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Zusammenfassung

Unter den ophthalmologischen Erkrankungen zählt das trockene Auge in seinen verschiedenen Formen gleichzeitig zu den häufigsten und zu den am wenigsten kausal therapierbaren. Seit einigen Jahren stellt sich zunehmend heraus, dass Sexualhormone eine wesentliche Rolle bei Entstehung und Verlauf spielen, woraus sich auch potenziell vielversprechende Therapieansätze ergeben. Ziel dieses Beitrags ist es, den heute bekannten wissenschaftlichen Hintergrund zur Relation der Androgene, Östrogene und Gestagene zur Tränendrüse einerseits und zur Meibom-Drüse andererseits zu umreißen.

Abstract

Among ophthalmic diseases dry eye in its various forms, represents an entity with one of the highest prevalences and at the same time the lowest chance for causal therapy. Since some years there is growing evidence that sex hormones play a key role in the formation and course of the disease and thus provide potentially promising approaches for therapy. The objective of this article is to briefly outline current scientific knowledge on the relationship between androgens, estrogens,and progesterones on the one hand and the lacrimal gland and Meibomian glands respectively.

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Authors and Affiliations

  1. Klinik für Augenheilkunde, Universitätsklinikum des Saarlandes, UKS, Kirrberger Str. 1, 66421, Homburg/Saar, Deutschland

    F. Schirra & B. Seitz

  2. Augenklinik-Forschungslabor, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Deutschland

    N. Knop & E. Knop

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  1. F. Schirra
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  2. B. Seitz
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  3. N. Knop
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  4. E. Knop
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Correspondence to F. Schirra.

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Schirra, F., Seitz, B., Knop, N. et al. Sexualhormone und trockenes Auge. Ophthalmologe 106, 988–994 (2009). https://doi.org/10.1007/s00347-009-2005-2

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